Two-Element Transcriptional Regulation in the Canonical Wnt Pathway

The canonical Wnt pathway regulates numerous fundamental processes throughout development and adult physiology and is often disrupted in diseases [1–4]. Signal in the pathway is transduced by β-catenin, which in complex with Tcf/Lef regulates transcription. Despite the many processes that the Wnt pa...

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Veröffentlicht in:	Current biology 2017-08, Vol.27 (15), p.2357-2364.e5
Hauptverfasser:	Kim, Kibeom, Cho, Jaehyoung, Hilzinger, Thomas S., Nunns, Harry, Liu, Andrew, Ryba, Bryan E., Goentoro, Lea
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals beta Catenin - genetics beta Catenin - metabolism Brachyury canonical Wnt pathway cis regulation Female gene transcription Humans Male Mice mouse embryonic stem cells siamois T Cell Transcription Factor 1 - genetics T Cell Transcription Factor 1 - metabolism Tcf Wnt Signaling Pathway Xenopus Xenopus laevis β-catenin
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