Expression and clinical significance of MAGE and NY-ESO-1 cancer-testis antigens in adenoid cystic carcinoma of the head and neck

Background Adenoid cystic carcinoma (ACC) of the head and neck is a rare but highly malignant tumor. Cancer‐testis antigens (CTAs) represent an immunogenic family of cancer‐specific proteins and thus represent an attractive target for immunotherapy. Methods Eighty‐four cases of ACC were identified,...

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Veröffentlicht in:	Head & neck 2016-07, Vol.38 (7), p.1008-1016
Hauptverfasser:	Veit, Johannes A., Heine, Daniela, Thierauf, Julia, Lennerz, Jochen, Shetty, Subasch, Schuler, Patrick J., Whiteside, Theresa, Beutner, Dirk, Meyer, Moritz, Grünewald, Inga, Ritter, Gerd, Gnjatic, Sacha, Sikora, Andrew G., Hoffmann, Thomas K., Laban, Simon
Format:	Artikel
Sprache:	eng
Schlagworte:	adenoid cystic carcinoma Adult Aged Antigens, Neoplasm - metabolism Biomarkers, Tumor - metabolism Biopsy, Needle cancer-testis antigens Carcinoma, Adenoid Cystic - blood Carcinoma, Adenoid Cystic - mortality Carcinoma, Adenoid Cystic - pathology Carcinoma, Adenoid Cystic - therapy Chi-Square Distribution Cohort Studies Disease-Free Survival Female head and neck cancer Head and Neck Neoplasms - blood Head and Neck Neoplasms - mortality Head and Neck Neoplasms - pathology Head and Neck Neoplasms - therapy Humans Immunohistochemistry Male Melanoma antigen Melanoma-Specific Antigens - metabolism Membrane Proteins - metabolism Middle Aged New York esophageal squamous cell carcinoma (NY-ESO-1) Prognosis Prospective Studies Risk Assessment Survival Analysis Treatment Outcome
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