Hysterectomy for benign conditions: Complications relative to surgical approach and other variables that lead to post-operative readmission within 90 days of surgery

Objective: To examine variables associated with hysterectomy-related complications, relative to surgical approach and other variables, that lead to readmission within 90 days of surgery. Methods: We conducted an observational cohort study for which data were extracted from electronic health records....

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Veröffentlicht in:Women's health (London, England) England), 2017-08, Vol.13 (2), p.17-26
Hauptverfasser: Lonky, Neal M, Mohan, Yasmina, Chiu, Vicki Y, Park, Jeanna, Kivnick, Seth, Hong, Christina, Hudson, Sharon M
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container_start_page 17
container_title Women's health (London, England)
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creator Lonky, Neal M
Mohan, Yasmina
Chiu, Vicki Y
Park, Jeanna
Kivnick, Seth
Hong, Christina
Hudson, Sharon M
description Objective: To examine variables associated with hysterectomy-related complications, relative to surgical approach and other variables, that lead to readmission within 90 days of surgery. Methods: We conducted an observational cohort study for which data were extracted from electronic health records. Data were extracted of all patients (n = 3106) who underwent hysterectomies at 10 Kaiser Permanente Southern California medical centers between June 2010 and September 2011. Patients who were pregnant or had a cancer diagnosis were excluded from the study. To identify univariate associations between examined variables and procedure type, chi-square tests for categorical variables and t-tests or analysis of variance for continuous variables were used. Generalized estimating equations methods were used to test associations between independent variables and primary outcomes of interest. Statistical significance was determined using a p-value 
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Methods: We conducted an observational cohort study for which data were extracted from electronic health records. Data were extracted of all patients (n = 3106) who underwent hysterectomies at 10 Kaiser Permanente Southern California medical centers between June 2010 and September 2011. Patients who were pregnant or had a cancer diagnosis were excluded from the study. To identify univariate associations between examined variables and procedure type, chi-square tests for categorical variables and t-tests or analysis of variance for continuous variables were used. Generalized estimating equations methods were used to test associations between independent variables and primary outcomes of interest. Statistical significance was determined using a p-value &lt;.05. Results: Of 3106 patients, 109 experienced 168 post-operative complications. The most common post-operative complications were related to pelvic abscesses, bowel obstruction, or severe ileus, and the vaginal cuff. Pelvic abscesses were most frequent among total laparoscopic hysterectomy and total abdominal hysterectomy cases (p = .002), and vaginal cuff complications were most frequent among total laparoscopic hysterectomy cases (p = .015). Patients who underwent total vaginal hysterectomy (odds ratio = 2.13, confidence interval = 1.15–3.92), laparoscopic supracervical hysterectomy (odds ratio = 3.11, confidence interval = 1.13–8.57), and total laparoscopic hysterectomy (odds ratio = 5.60, confidence interval = 2.90–10.79) experienced increased occurrence of post-operative complications resulting in readmission. Other variables associated with an increased risk for readmission included high estimated blood loss (201–300 mL and 301+ mL, relative to 0–50 mL; odds ratio = 2.28, confidence interval = 1.24–4.18 and odds ratio = 2.63, confidence interval = 1.67–4.14) and long length of stay of 3 days or more (relative to 0 days; odds ratio = 2.93, confidence interval = 1.28–6.69). Pelvic specimen weight in the 151–300 g and 501+ g ranges appeared protective (odds ratio = 0.40, confidence interval = 0.25–0.64 and odds ratio = 0.54, confidence interval = 0.33–0.90). In a sub-analysis of 1294 patients, 74 hospital operative complications directly related to hysterectomy were identified among 59 patients. The most common hospital operative complications were excessive bleeding associated with surgery or injury to nearby structures. Among the sub-sample of 1294 patients, those with hospital operative complications were more likely to experience post-operative complications that lead to readmission (odds ratio = 3.82, confidence interval = 1.55–9.43, p = .004). Conclusion: The observed increased risk of complications among patients of Black race, who underwent laparoscopic supracervical hysterectomy or total laparoscopic hysterectomy, who experienced more than 300 mL surgical blood loss, who suffered hospital operative complications, and those whose hospitalization was 3 days or greater, offers an opportunity for higher scrutiny and preventive measures during usual hysterectomy care to prevent later readmission.</description><identifier>ISSN: 1745-5065</identifier><identifier>ISSN: 1745-5057</identifier><identifier>EISSN: 1745-5065</identifier><identifier>DOI: 10.1177/1745505717714657</identifier><identifier>PMID: 28660800</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Abscesses ; Adult ; Benign ; Bleeding ; Blood ; Cancer ; Cohort Studies ; Complications ; Confidence intervals ; Diagnosis ; Electronic health records ; Electronic medical records ; Female ; Health care facilities ; Humans ; Hysterectomy ; Hysterectomy - adverse effects ; Ileus - etiology ; Independent variables ; Intestinal Obstruction - etiology ; Intestine ; Laparoscopy ; Laparoscopy - adverse effects ; Length of Stay - statistics &amp; numerical data ; Mathematical models ; Middle Aged ; Patient Readmission - statistics &amp; numerical data ; Patients ; Pelvic Infection - etiology ; Postoperative Complications - epidemiology ; Postoperative Complications - etiology ; Postoperative Period ; Pregnancy ; Primary ; Risk ; Statistical tests ; Surgery ; Vagina ; Variance analysis</subject><ispartof>Women's health (London, England), 2017-08, Vol.13 (2), p.17-26</ispartof><rights>The Author(s) 2017</rights><rights>The Author(s) 2017 2017 SAGE Publications Ltd unless otherwise noted. Manuscript content on this site is licensed under Creative Commons Licenses</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c462t-21902055a5f4d526a5b84ea89517da77b041b93f5a152d0fb768dcad3f7a44893</citedby><cites>FETCH-LOGICAL-c462t-21902055a5f4d526a5b84ea89517da77b041b93f5a152d0fb768dcad3f7a44893</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5557180/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5557180/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,21966,27853,27924,27925,44945,45333,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28660800$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lonky, Neal M</creatorcontrib><creatorcontrib>Mohan, Yasmina</creatorcontrib><creatorcontrib>Chiu, Vicki Y</creatorcontrib><creatorcontrib>Park, Jeanna</creatorcontrib><creatorcontrib>Kivnick, Seth</creatorcontrib><creatorcontrib>Hong, Christina</creatorcontrib><creatorcontrib>Hudson, Sharon M</creatorcontrib><title>Hysterectomy for benign conditions: Complications relative to surgical approach and other variables that lead to post-operative readmission within 90 days of surgery</title><title>Women's health (London, England)</title><addtitle>Womens Health (Lond)</addtitle><description>Objective: To examine variables associated with hysterectomy-related complications, relative to surgical approach and other variables, that lead to readmission within 90 days of surgery. Methods: We conducted an observational cohort study for which data were extracted from electronic health records. Data were extracted of all patients (n = 3106) who underwent hysterectomies at 10 Kaiser Permanente Southern California medical centers between June 2010 and September 2011. Patients who were pregnant or had a cancer diagnosis were excluded from the study. To identify univariate associations between examined variables and procedure type, chi-square tests for categorical variables and t-tests or analysis of variance for continuous variables were used. Generalized estimating equations methods were used to test associations between independent variables and primary outcomes of interest. Statistical significance was determined using a p-value &lt;.05. Results: Of 3106 patients, 109 experienced 168 post-operative complications. The most common post-operative complications were related to pelvic abscesses, bowel obstruction, or severe ileus, and the vaginal cuff. Pelvic abscesses were most frequent among total laparoscopic hysterectomy and total abdominal hysterectomy cases (p = .002), and vaginal cuff complications were most frequent among total laparoscopic hysterectomy cases (p = .015). Patients who underwent total vaginal hysterectomy (odds ratio = 2.13, confidence interval = 1.15–3.92), laparoscopic supracervical hysterectomy (odds ratio = 3.11, confidence interval = 1.13–8.57), and total laparoscopic hysterectomy (odds ratio = 5.60, confidence interval = 2.90–10.79) experienced increased occurrence of post-operative complications resulting in readmission. Other variables associated with an increased risk for readmission included high estimated blood loss (201–300 mL and 301+ mL, relative to 0–50 mL; odds ratio = 2.28, confidence interval = 1.24–4.18 and odds ratio = 2.63, confidence interval = 1.67–4.14) and long length of stay of 3 days or more (relative to 0 days; odds ratio = 2.93, confidence interval = 1.28–6.69). Pelvic specimen weight in the 151–300 g and 501+ g ranges appeared protective (odds ratio = 0.40, confidence interval = 0.25–0.64 and odds ratio = 0.54, confidence interval = 0.33–0.90). In a sub-analysis of 1294 patients, 74 hospital operative complications directly related to hysterectomy were identified among 59 patients. The most common hospital operative complications were excessive bleeding associated with surgery or injury to nearby structures. Among the sub-sample of 1294 patients, those with hospital operative complications were more likely to experience post-operative complications that lead to readmission (odds ratio = 3.82, confidence interval = 1.55–9.43, p = .004). Conclusion: The observed increased risk of complications among patients of Black race, who underwent laparoscopic supracervical hysterectomy or total laparoscopic hysterectomy, who experienced more than 300 mL surgical blood loss, who suffered hospital operative complications, and those whose hospitalization was 3 days or greater, offers an opportunity for higher scrutiny and preventive measures during usual hysterectomy care to prevent later readmission.</description><subject>Abscesses</subject><subject>Adult</subject><subject>Benign</subject><subject>Bleeding</subject><subject>Blood</subject><subject>Cancer</subject><subject>Cohort Studies</subject><subject>Complications</subject><subject>Confidence intervals</subject><subject>Diagnosis</subject><subject>Electronic health records</subject><subject>Electronic medical records</subject><subject>Female</subject><subject>Health care facilities</subject><subject>Humans</subject><subject>Hysterectomy</subject><subject>Hysterectomy - adverse effects</subject><subject>Ileus - etiology</subject><subject>Independent variables</subject><subject>Intestinal Obstruction - etiology</subject><subject>Intestine</subject><subject>Laparoscopy</subject><subject>Laparoscopy - adverse effects</subject><subject>Length of Stay - statistics &amp; numerical data</subject><subject>Mathematical models</subject><subject>Middle Aged</subject><subject>Patient Readmission - statistics &amp; numerical data</subject><subject>Patients</subject><subject>Pelvic Infection - etiology</subject><subject>Postoperative Complications - epidemiology</subject><subject>Postoperative Complications - etiology</subject><subject>Postoperative Period</subject><subject>Pregnancy</subject><subject>Primary</subject><subject>Risk</subject><subject>Statistical tests</subject><subject>Surgery</subject><subject>Vagina</subject><subject>Variance analysis</subject><issn>1745-5065</issn><issn>1745-5057</issn><issn>1745-5065</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>AFRWT</sourceid><sourceid>EIF</sourceid><recordid>eNp1kk1v1DAQhiMEoh9w54QsceESsLP-SDggoRWlSJW4wDmaxJONK8cOtrMoP4j_ibdbqqUSJ7-eeeexRzNF8YrRd4wp9Z4pLgQVKmvGpVBPivNDqBRUiqcn-qy4iPGWUi4bzp4XZ1UtJa0pPS9-X68xYcA--Wklgw-kQ2d2jvTeaZOMd_ED2fpptqaHuysJaLPaI0mexCXscsISmOfgoR8JOE18GjGQPQQDncVI0giJWAR9KJl9TKWfMRwhIYcnE2NGk18mjcaRhhINayR-uONjWF8UzwawEV_en5fFj6vP37fX5c23L1-3n27KnssqlRVraEWFADFwLSoJoqs5Qt0IpjQo1VHOumYzCGCi0nTolKx1D3ozKOC8bjaXxccjd166CXWPLgWw7RzMBGFtPZj234wzY7vz-1aIPISaZsDbe0DwPxeMqc299WgtOPRLbFnDeM1r0chsffPIeuuX4HJ72VWpjVBSsOyiR1cffIwBh4fPMNoedqB9vAO55PVpEw8Ff4eeDeXREGGHJ6_-D_gHjfa9ZA</recordid><startdate>20170801</startdate><enddate>20170801</enddate><creator>Lonky, Neal M</creator><creator>Mohan, Yasmina</creator><creator>Chiu, Vicki Y</creator><creator>Park, Jeanna</creator><creator>Kivnick, Seth</creator><creator>Hong, Christina</creator><creator>Hudson, Sharon M</creator><general>SAGE Publications</general><general>Sage Publications Ltd</general><scope>AFRWT</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20170801</creationdate><title>Hysterectomy for benign conditions: Complications relative to surgical approach and other variables that lead to post-operative readmission within 90 days of surgery</title><author>Lonky, Neal M ; Mohan, Yasmina ; Chiu, Vicki Y ; Park, Jeanna ; Kivnick, Seth ; Hong, Christina ; Hudson, Sharon M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c462t-21902055a5f4d526a5b84ea89517da77b041b93f5a152d0fb768dcad3f7a44893</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Abscesses</topic><topic>Adult</topic><topic>Benign</topic><topic>Bleeding</topic><topic>Blood</topic><topic>Cancer</topic><topic>Cohort Studies</topic><topic>Complications</topic><topic>Confidence intervals</topic><topic>Diagnosis</topic><topic>Electronic health records</topic><topic>Electronic medical records</topic><topic>Female</topic><topic>Health care facilities</topic><topic>Humans</topic><topic>Hysterectomy</topic><topic>Hysterectomy - adverse effects</topic><topic>Ileus - etiology</topic><topic>Independent variables</topic><topic>Intestinal Obstruction - etiology</topic><topic>Intestine</topic><topic>Laparoscopy</topic><topic>Laparoscopy - adverse effects</topic><topic>Length of Stay - statistics &amp; numerical data</topic><topic>Mathematical models</topic><topic>Middle Aged</topic><topic>Patient Readmission - statistics &amp; numerical data</topic><topic>Patients</topic><topic>Pelvic Infection - etiology</topic><topic>Postoperative Complications - epidemiology</topic><topic>Postoperative Complications - etiology</topic><topic>Postoperative Period</topic><topic>Pregnancy</topic><topic>Primary</topic><topic>Risk</topic><topic>Statistical tests</topic><topic>Surgery</topic><topic>Vagina</topic><topic>Variance analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lonky, Neal M</creatorcontrib><creatorcontrib>Mohan, Yasmina</creatorcontrib><creatorcontrib>Chiu, Vicki Y</creatorcontrib><creatorcontrib>Park, Jeanna</creatorcontrib><creatorcontrib>Kivnick, Seth</creatorcontrib><creatorcontrib>Hong, Christina</creatorcontrib><creatorcontrib>Hudson, Sharon M</creatorcontrib><collection>Sage Journals GOLD Open Access 2024</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Nursing &amp; Allied Health Premium</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Women's health (London, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lonky, Neal M</au><au>Mohan, Yasmina</au><au>Chiu, Vicki Y</au><au>Park, Jeanna</au><au>Kivnick, Seth</au><au>Hong, Christina</au><au>Hudson, Sharon M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hysterectomy for benign conditions: Complications relative to surgical approach and other variables that lead to post-operative readmission within 90 days of surgery</atitle><jtitle>Women's health (London, England)</jtitle><addtitle>Womens Health (Lond)</addtitle><date>2017-08-01</date><risdate>2017</risdate><volume>13</volume><issue>2</issue><spage>17</spage><epage>26</epage><pages>17-26</pages><issn>1745-5065</issn><issn>1745-5057</issn><eissn>1745-5065</eissn><abstract>Objective: To examine variables associated with hysterectomy-related complications, relative to surgical approach and other variables, that lead to readmission within 90 days of surgery. Methods: We conducted an observational cohort study for which data were extracted from electronic health records. Data were extracted of all patients (n = 3106) who underwent hysterectomies at 10 Kaiser Permanente Southern California medical centers between June 2010 and September 2011. Patients who were pregnant or had a cancer diagnosis were excluded from the study. To identify univariate associations between examined variables and procedure type, chi-square tests for categorical variables and t-tests or analysis of variance for continuous variables were used. Generalized estimating equations methods were used to test associations between independent variables and primary outcomes of interest. Statistical significance was determined using a p-value &lt;.05. Results: Of 3106 patients, 109 experienced 168 post-operative complications. The most common post-operative complications were related to pelvic abscesses, bowel obstruction, or severe ileus, and the vaginal cuff. Pelvic abscesses were most frequent among total laparoscopic hysterectomy and total abdominal hysterectomy cases (p = .002), and vaginal cuff complications were most frequent among total laparoscopic hysterectomy cases (p = .015). Patients who underwent total vaginal hysterectomy (odds ratio = 2.13, confidence interval = 1.15–3.92), laparoscopic supracervical hysterectomy (odds ratio = 3.11, confidence interval = 1.13–8.57), and total laparoscopic hysterectomy (odds ratio = 5.60, confidence interval = 2.90–10.79) experienced increased occurrence of post-operative complications resulting in readmission. Other variables associated with an increased risk for readmission included high estimated blood loss (201–300 mL and 301+ mL, relative to 0–50 mL; odds ratio = 2.28, confidence interval = 1.24–4.18 and odds ratio = 2.63, confidence interval = 1.67–4.14) and long length of stay of 3 days or more (relative to 0 days; odds ratio = 2.93, confidence interval = 1.28–6.69). Pelvic specimen weight in the 151–300 g and 501+ g ranges appeared protective (odds ratio = 0.40, confidence interval = 0.25–0.64 and odds ratio = 0.54, confidence interval = 0.33–0.90). In a sub-analysis of 1294 patients, 74 hospital operative complications directly related to hysterectomy were identified among 59 patients. The most common hospital operative complications were excessive bleeding associated with surgery or injury to nearby structures. Among the sub-sample of 1294 patients, those with hospital operative complications were more likely to experience post-operative complications that lead to readmission (odds ratio = 3.82, confidence interval = 1.55–9.43, p = .004). Conclusion: The observed increased risk of complications among patients of Black race, who underwent laparoscopic supracervical hysterectomy or total laparoscopic hysterectomy, who experienced more than 300 mL surgical blood loss, who suffered hospital operative complications, and those whose hospitalization was 3 days or greater, offers an opportunity for higher scrutiny and preventive measures during usual hysterectomy care to prevent later readmission.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>28660800</pmid><doi>10.1177/1745505717714657</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record>
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subjects Abscesses
Adult
Benign
Bleeding
Blood
Cancer
Cohort Studies
Complications
Confidence intervals
Diagnosis
Electronic health records
Electronic medical records
Female
Health care facilities
Humans
Hysterectomy
Hysterectomy - adverse effects
Ileus - etiology
Independent variables
Intestinal Obstruction - etiology
Intestine
Laparoscopy
Laparoscopy - adverse effects
Length of Stay - statistics & numerical data
Mathematical models
Middle Aged
Patient Readmission - statistics & numerical data
Patients
Pelvic Infection - etiology
Postoperative Complications - epidemiology
Postoperative Complications - etiology
Postoperative Period
Pregnancy
Primary
Risk
Statistical tests
Surgery
Vagina
Variance analysis
title Hysterectomy for benign conditions: Complications relative to surgical approach and other variables that lead to post-operative readmission within 90 days of surgery
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