Population pharmacokinetic and exposure-response analysis of nilotinib in patients with newly diagnosed Ph+ chronic myeloid leukemia in chronic phase

Purpose We investigated the population pharmacokinetics and exposure-response relationship of nilotinib in patients with newly diagnosed chronic myeloid leukemia (CML) in chronic phase. Methods Nilotinib was given at 300 mg or 400 mg twice daily. Serum concentration data (sparse and full pharmacokin...

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Veröffentlicht in:	European journal of clinical pharmacology 2012-05, Vol.68 (5), p.723-733
Hauptverfasser:	Larson, Richard A., Yin, Ophelia Q. P., Hochhaus, Andreas, Saglio, Giuseppe, Clark, Richard E., Nakamae, Hirohisa, Gallagher, Neil J., Demirhan, Eren, Hughes, Timothy P., Kantarjian, Hagop M., le Coutre, Philipp D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Aged, 80 and over Antineoplastic Agents - administration & dosage Antineoplastic Agents - blood Antineoplastic Agents - pharmacokinetics Antineoplastic Agents - therapeutic use Bilirubin Bioavailability Biological and medical sciences Biological Availability Biomedical and Life Sciences Biomedicine Blood levels Chronic myeloid leukemia Cohort Studies Data processing Demography Dose-response effects Dose-Response Relationship, Drug Drug therapy EKG Female Fusion Proteins, bcr-abl - antagonists & inhibitors Hematologic and hematopoietic diseases Humans Leukemia Leukemia, Myeloid, Chronic-Phase - blood Leukemia, Myeloid, Chronic-Phase - drug therapy Leukemia, Myeloid, Chronic-Phase - metabolism Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Male Medical sciences Metabolic Clearance Rate Middle Aged Models, Biological Pharmacokinetics Pharmacokinetics and Disposition Pharmacology Pharmacology. Drug treatments Pharmacology/Toxicology Protein Kinase Inhibitors - administration & dosage Protein Kinase Inhibitors - blood Protein Kinase Inhibitors - pharmacokinetics Protein Kinase Inhibitors - therapeutic use Protein-Tyrosine Kinases - antagonists & inhibitors Pyrimidines - administration & dosage Pyrimidines - blood Pyrimidines - pharmacokinetics Pyrimidines - therapeutic use Regression analysis Young Adult
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