Post-mortem imaging of the infant and perinatal dura mater and superior sagittal sinus using optical coherence tomography
Infants and young children are likely to present with subdural haemorrhage (SDH) if they are the victims of abusive head trauma. In these cases, the most accepted theory for the source of bleeding is the bridging veins traversing from the surface of the brain to the dura mater. However, some have su...
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description | Infants and young children are likely to present with subdural haemorrhage (SDH) if they are the victims of abusive head trauma. In these cases, the most accepted theory for the source of bleeding is the bridging veins traversing from the surface of the brain to the dura mater. However, some have suggested that SDH may result from leakage of blood from a dural vascular plexus. As post-mortem examination of the bridging veins and dura is challenging, and imaging modalities such as magnetic resonance and computed tomography do not have the resolution capabilities to image small blood vessels, we have trialled the use of intravascular and benchtop optical coherence tomography (OCT) systems for imaging from within the superior sagittal sinus (SSS) and through the dura during five infant/perinatal autopsies. Numerous vessel-like structures were identified using both OCT systems. Measurements taken with the intravascular rotational system indicate that the approximate median diameters of blood vessels entering anterior and posterior segments of the SSS were 110 μm (range 70 to 670 μm,
n
= 21) and 125 μm (range 70 to 740 μm,
n
= 23), respectively. For blood vessels close to the wall of the SSS, the median diameters for anterior and posterior segments of the SSS were 80 μm (range 40 to 170 μm,
n
= 25) and 90 μm (range 30 to 150 μm), respectively. Detailed characterisation of the dural vasculature is important to aid understanding of the source of SDH. High resolution 3-dimensional reconstructions of the infant dural vasculature may be possible with further development of OCT systems. |
doi_str_mv | 10.1007/s00414-017-1570-1 |
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n
= 21) and 125 μm (range 70 to 740 μm,
n
= 23), respectively. For blood vessels close to the wall of the SSS, the median diameters for anterior and posterior segments of the SSS were 80 μm (range 40 to 170 μm,
n
= 25) and 90 μm (range 30 to 150 μm), respectively. Detailed characterisation of the dural vasculature is important to aid understanding of the source of SDH. High resolution 3-dimensional reconstructions of the infant dural vasculature may be possible with further development of OCT systems.</description><identifier>ISSN: 0937-9827</identifier><identifier>EISSN: 1437-1596</identifier><identifier>DOI: 10.1007/s00414-017-1570-1</identifier><identifier>PMID: 28389927</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Autopsies ; Bleeding ; Blood vessels ; Brain ; Bridging ; Children ; Coherence ; Computed tomography ; Forensic Medicine ; High resolution ; Imaging ; Infants ; Magnetic resonance ; Medical imaging ; Medical Law ; Medicine ; Medicine & Public Health ; Methods Paper ; Optical Coherence Tomography ; Segments ; Tomography ; Veins</subject><ispartof>International journal of legal medicine, 2017-09, Vol.131 (5), p.1377-1383</ispartof><rights>The Author(s) 2017</rights><rights>International Journal of Legal Medicine is a copyright of Springer, 2017.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c470t-1e4edbb1de53c842146c1b56541d256de044acae1c188bb79da716f9220647ef3</citedby><cites>FETCH-LOGICAL-c470t-1e4edbb1de53c842146c1b56541d256de044acae1c188bb79da716f9220647ef3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00414-017-1570-1$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00414-017-1570-1$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,780,784,885,27922,27923,41486,42555,51317</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28389927$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cheshire, Emma C.</creatorcontrib><creatorcontrib>Malcomson, Roger D. G.</creatorcontrib><creatorcontrib>Joseph, Shiju</creatorcontrib><creatorcontrib>Adnan, Asif</creatorcontrib><creatorcontrib>Adlam, David</creatorcontrib><creatorcontrib>Rutty, Guy N.</creatorcontrib><title>Post-mortem imaging of the infant and perinatal dura mater and superior sagittal sinus using optical coherence tomography</title><title>International journal of legal medicine</title><addtitle>Int J Legal Med</addtitle><addtitle>Int J Legal Med</addtitle><description>Infants and young children are likely to present with subdural haemorrhage (SDH) if they are the victims of abusive head trauma. In these cases, the most accepted theory for the source of bleeding is the bridging veins traversing from the surface of the brain to the dura mater. However, some have suggested that SDH may result from leakage of blood from a dural vascular plexus. As post-mortem examination of the bridging veins and dura is challenging, and imaging modalities such as magnetic resonance and computed tomography do not have the resolution capabilities to image small blood vessels, we have trialled the use of intravascular and benchtop optical coherence tomography (OCT) systems for imaging from within the superior sagittal sinus (SSS) and through the dura during five infant/perinatal autopsies. Numerous vessel-like structures were identified using both OCT systems. Measurements taken with the intravascular rotational system indicate that the approximate median diameters of blood vessels entering anterior and posterior segments of the SSS were 110 μm (range 70 to 670 μm,
n
= 21) and 125 μm (range 70 to 740 μm,
n
= 23), respectively. For blood vessels close to the wall of the SSS, the median diameters for anterior and posterior segments of the SSS were 80 μm (range 40 to 170 μm,
n
= 25) and 90 μm (range 30 to 150 μm), respectively. Detailed characterisation of the dural vasculature is important to aid understanding of the source of SDH. High resolution 3-dimensional reconstructions of the infant dural vasculature may be possible with further development of OCT systems.</description><subject>Autopsies</subject><subject>Bleeding</subject><subject>Blood vessels</subject><subject>Brain</subject><subject>Bridging</subject><subject>Children</subject><subject>Coherence</subject><subject>Computed tomography</subject><subject>Forensic Medicine</subject><subject>High resolution</subject><subject>Imaging</subject><subject>Infants</subject><subject>Magnetic resonance</subject><subject>Medical imaging</subject><subject>Medical Law</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Methods Paper</subject><subject>Optical Coherence Tomography</subject><subject>Segments</subject><subject>Tomography</subject><subject>Veins</subject><issn>0937-9827</issn><issn>1437-1596</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNp1kU9v1DAQxS0EotvCB-CCLHHhEvA4_pNckFAFFKkSHOBsOc4kmyqxF9uptN8ep1uqgsTJ9rzfvPHoEfIK2DtgTL9PjAkQFQNdgdSsgidkB6LeXq16SnasLfe24fqMnKd0wwqotHxOznhTN23L9Y4cv4eUqyXEjAudFjtOfqRhoHmPdPKD9Zla39MDxsnbbGfar9HSxWaMd0JaNylEmkpr3oA0-TXRNd0ZHfLkSs2FPUb0DmkOSxijPeyPL8izwc4JX96fF-Tn508_Lq-q629fvl5-vK6c0CxXgAL7roMeZe0awUEoB51UUkDPpeqRCWGdRXDQNF2n295qUEPLOVNC41BfkA8n38PaLdg79Dna2Rxi2TYeTbCT-Vvx096M4dZIKRXUohi8vTeI4deKKZtlSg7n2XoMazJlrmwlgOIFffMPehPW6Mt6BlreqIJqVig4US6GlCIOD58BZrZgzSlYU_IyW7AGSs_rx1s8dPxJsgD8BKQi-RHjo9H_df0NnDKxGw</recordid><startdate>20170901</startdate><enddate>20170901</enddate><creator>Cheshire, Emma C.</creator><creator>Malcomson, Roger D. 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G. ; Joseph, Shiju ; Adnan, Asif ; Adlam, David ; Rutty, Guy N.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c470t-1e4edbb1de53c842146c1b56541d256de044acae1c188bb79da716f9220647ef3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Autopsies</topic><topic>Bleeding</topic><topic>Blood vessels</topic><topic>Brain</topic><topic>Bridging</topic><topic>Children</topic><topic>Coherence</topic><topic>Computed tomography</topic><topic>Forensic Medicine</topic><topic>High resolution</topic><topic>Imaging</topic><topic>Infants</topic><topic>Magnetic resonance</topic><topic>Medical imaging</topic><topic>Medical Law</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Methods Paper</topic><topic>Optical Coherence Tomography</topic><topic>Segments</topic><topic>Tomography</topic><topic>Veins</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cheshire, Emma C.</creatorcontrib><creatorcontrib>Malcomson, Roger D. G.</creatorcontrib><creatorcontrib>Joseph, Shiju</creatorcontrib><creatorcontrib>Adnan, Asif</creatorcontrib><creatorcontrib>Adlam, David</creatorcontrib><creatorcontrib>Rutty, Guy N.</creatorcontrib><collection>Springer</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Social Sciences Premium Collection【Remote access available】</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Complete (ProQuest Database)</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Criminal Justice Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>Social Science Premium Collection</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>Technology Collection</collection><collection>Criminology Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Criminal Justice (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Engineering Collection</collection><collection>Criminal Justice Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Engineering Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Engineering Collection</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International journal of legal medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cheshire, Emma C.</au><au>Malcomson, Roger D. G.</au><au>Joseph, Shiju</au><au>Adnan, Asif</au><au>Adlam, David</au><au>Rutty, Guy N.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Post-mortem imaging of the infant and perinatal dura mater and superior sagittal sinus using optical coherence tomography</atitle><jtitle>International journal of legal medicine</jtitle><stitle>Int J Legal Med</stitle><addtitle>Int J Legal Med</addtitle><date>2017-09-01</date><risdate>2017</risdate><volume>131</volume><issue>5</issue><spage>1377</spage><epage>1383</epage><pages>1377-1383</pages><issn>0937-9827</issn><eissn>1437-1596</eissn><abstract>Infants and young children are likely to present with subdural haemorrhage (SDH) if they are the victims of abusive head trauma. In these cases, the most accepted theory for the source of bleeding is the bridging veins traversing from the surface of the brain to the dura mater. However, some have suggested that SDH may result from leakage of blood from a dural vascular plexus. As post-mortem examination of the bridging veins and dura is challenging, and imaging modalities such as magnetic resonance and computed tomography do not have the resolution capabilities to image small blood vessels, we have trialled the use of intravascular and benchtop optical coherence tomography (OCT) systems for imaging from within the superior sagittal sinus (SSS) and through the dura during five infant/perinatal autopsies. Numerous vessel-like structures were identified using both OCT systems. Measurements taken with the intravascular rotational system indicate that the approximate median diameters of blood vessels entering anterior and posterior segments of the SSS were 110 μm (range 70 to 670 μm,
n
= 21) and 125 μm (range 70 to 740 μm,
n
= 23), respectively. For blood vessels close to the wall of the SSS, the median diameters for anterior and posterior segments of the SSS were 80 μm (range 40 to 170 μm,
n
= 25) and 90 μm (range 30 to 150 μm), respectively. Detailed characterisation of the dural vasculature is important to aid understanding of the source of SDH. High resolution 3-dimensional reconstructions of the infant dural vasculature may be possible with further development of OCT systems.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>28389927</pmid><doi>10.1007/s00414-017-1570-1</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Autopsies Bleeding Blood vessels Brain Bridging Children Coherence Computed tomography Forensic Medicine High resolution Imaging Infants Magnetic resonance Medical imaging Medical Law Medicine Medicine & Public Health Methods Paper Optical Coherence Tomography Segments Tomography Veins |
title | Post-mortem imaging of the infant and perinatal dura mater and superior sagittal sinus using optical coherence tomography |
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