Solute carrier protein family 11 member 1 (Slc11a1) activation efficiently inhibits Leishmania donovani survival in host macrophages
Visceral leishmaniasis (kala-azar), a life threatening disease caused by L. donovani , is a latent threat to more than 147 million people living in disease endemic South East Asia region of the Indian subcontinent. The therapeutic option to control leishmanial infections are very limited, and at pre...
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| Veröffentlicht in: | Journal of parasitic diseases 2017-09, Vol.41 (3), p.671-677 |
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| creator | Singh, Nisha Gedda, Mallikarjuna Rao Tiwari, Neeraj Singh, Suya P. Bajpai, Surabhi Singh, Rakesh K. |
| description | Visceral leishmaniasis (kala-azar), a life threatening disease caused by
L. donovani
, is a latent threat to more than 147 million people living in disease endemic South East Asia region of the Indian subcontinent. The therapeutic option to control leishmanial infections are very limited, and at present comprise only two drugs, an antifungal amphotericin B and an antitumor miltefosine, which are also highly vulnerable for parasitic resistance. Therefore, identification and development of alternate control measures is an exigent requirement to control leishmanial infections. In this study, we report that functionally induced expression of solute carrier protein family 11 member 1
(
Slc11a1), a transmembrane divalent cationic transporter recruited on the surface of phagolysosomes after phagocytosis of parasites, effectively inhibits
Leishmania donovani
growth in host macrophages. Further, the increased Slc11a1 functionality also resulted in increased production of NOx, TNF-α and IL-12 by activated macrophages. The findings of this study signify the importance of interplay between Slc11a1 expression and macrophages activation that can be effectively used to control of
Leishmania
growth and survival. |
| doi_str_mv | 10.1007/s12639-016-0864-4 |
| format | Article |
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L. donovani
, is a latent threat to more than 147 million people living in disease endemic South East Asia region of the Indian subcontinent. The therapeutic option to control leishmanial infections are very limited, and at present comprise only two drugs, an antifungal amphotericin B and an antitumor miltefosine, which are also highly vulnerable for parasitic resistance. Therefore, identification and development of alternate control measures is an exigent requirement to control leishmanial infections. In this study, we report that functionally induced expression of solute carrier protein family 11 member 1
(
Slc11a1), a transmembrane divalent cationic transporter recruited on the surface of phagolysosomes after phagocytosis of parasites, effectively inhibits
Leishmania donovani
growth in host macrophages. Further, the increased Slc11a1 functionality also resulted in increased production of NOx, TNF-α and IL-12 by activated macrophages. The findings of this study signify the importance of interplay between Slc11a1 expression and macrophages activation that can be effectively used to control of
Leishmania
growth and survival.</description><identifier>ISSN: 0971-7196</identifier><identifier>EISSN: 0975-0703</identifier><identifier>DOI: 10.1007/s12639-016-0864-4</identifier><identifier>PMID: 28848257</identifier><language>eng</language><publisher>New Delhi: Springer India</publisher><subject>Amphotericin B ; Cell activation ; control methods ; drugs ; Health Promotion and Disease Prevention ; India ; Infectious Diseases ; Interleukin 12 ; Leishmania donovani ; Macrophages ; Medicine ; Medicine & Public Health ; Miltefosine ; nitrogen oxides ; Original ; Original Article ; Parasites ; people ; Phagocytosis ; Phagolysosomes ; phagosomes ; solutes ; South East Asia ; Survival ; tumor necrosis factor-alpha ; Visceral leishmaniasis</subject><ispartof>Journal of parasitic diseases, 2017-09, Vol.41 (3), p.671-677</ispartof><rights>Indian Society for Parasitology 2016</rights><rights>Copyright Springer Science & Business Media 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4184-5cac709a634288265b46b81461ba7df95530c01e7270b79b5be93b3e21baf88d3</citedby><cites>FETCH-LOGICAL-c4184-5cac709a634288265b46b81461ba7df95530c01e7270b79b5be93b3e21baf88d3</cites><orcidid>0000-0003-0977-1461</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5555910/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5555910/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,41464,42533,51294,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28848257$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Singh, Nisha</creatorcontrib><creatorcontrib>Gedda, Mallikarjuna Rao</creatorcontrib><creatorcontrib>Tiwari, Neeraj</creatorcontrib><creatorcontrib>Singh, Suya P.</creatorcontrib><creatorcontrib>Bajpai, Surabhi</creatorcontrib><creatorcontrib>Singh, Rakesh K.</creatorcontrib><title>Solute carrier protein family 11 member 1 (Slc11a1) activation efficiently inhibits Leishmania donovani survival in host macrophages</title><title>Journal of parasitic diseases</title><addtitle>J Parasit Dis</addtitle><addtitle>J Parasit Dis</addtitle><description>Visceral leishmaniasis (kala-azar), a life threatening disease caused by
L. donovani
, is a latent threat to more than 147 million people living in disease endemic South East Asia region of the Indian subcontinent. The therapeutic option to control leishmanial infections are very limited, and at present comprise only two drugs, an antifungal amphotericin B and an antitumor miltefosine, which are also highly vulnerable for parasitic resistance. Therefore, identification and development of alternate control measures is an exigent requirement to control leishmanial infections. In this study, we report that functionally induced expression of solute carrier protein family 11 member 1
(
Slc11a1), a transmembrane divalent cationic transporter recruited on the surface of phagolysosomes after phagocytosis of parasites, effectively inhibits
Leishmania donovani
growth in host macrophages. Further, the increased Slc11a1 functionality also resulted in increased production of NOx, TNF-α and IL-12 by activated macrophages. The findings of this study signify the importance of interplay between Slc11a1 expression and macrophages activation that can be effectively used to control of
Leishmania
growth and survival.</description><subject>Amphotericin B</subject><subject>Cell activation</subject><subject>control methods</subject><subject>drugs</subject><subject>Health Promotion and Disease Prevention</subject><subject>India</subject><subject>Infectious Diseases</subject><subject>Interleukin 12</subject><subject>Leishmania donovani</subject><subject>Macrophages</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Miltefosine</subject><subject>nitrogen oxides</subject><subject>Original</subject><subject>Original Article</subject><subject>Parasites</subject><subject>people</subject><subject>Phagocytosis</subject><subject>Phagolysosomes</subject><subject>phagosomes</subject><subject>solutes</subject><subject>South East Asia</subject><subject>Survival</subject><subject>tumor necrosis factor-alpha</subject><subject>Visceral leishmaniasis</subject><issn>0971-7196</issn><issn>0975-0703</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNqFkk2LFDEQhhtR3HX0B3iRgJf10JrqzudFkMUvGPCweg5JJj2TpTsZk-6BvfvDrXHWZRXEXFLkfepNVVJN8xzoa6BUvqnQiV63FERLlWAte9CcUy15SyXtH_6KoZWgxVnzpNZrSjmeq8fNWacUUx2X582PqzwucyDelhJDIfuS5xATGewUxxsCQKYwORSAXFyNHsDCK2L9HA92jjmRMAzRx5BmhGPaRRfnStYh1t1kU7Rkk1M-YETqUg6YNCJFdrnOZLK-5P3ObkN92jwa7FjDs9t91Xz78P7r5ad2_eXj58t369YzUKzl3npJtRU9wwY6wR0TTgET4KzcDJrznnoKQXaSOqkdd0H3rg8d6oNSm37VvD357hc3hY3Hsosdzb7EyZYbk200fyop7sw2HwzHpYGiwcWtQcnfl1BnM8XqwzjaFPJSTUcpZQqkFP9FQfc910JphujLv9DrvJSEL4EUdgpaIrxq4EThs9VawnBXN1BzHAdzGgeD42CO42COzi_uN3yX8fv_EehOQEUpbUO5d_U_XX8CuNPA7A</recordid><startdate>20170901</startdate><enddate>20170901</enddate><creator>Singh, Nisha</creator><creator>Gedda, Mallikarjuna Rao</creator><creator>Tiwari, Neeraj</creator><creator>Singh, Suya P.</creator><creator>Bajpai, Surabhi</creator><creator>Singh, Rakesh K.</creator><general>Springer India</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7S9</scope><scope>L.6</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-0977-1461</orcidid></search><sort><creationdate>20170901</creationdate><title>Solute carrier protein family 11 member 1 (Slc11a1) activation efficiently inhibits Leishmania donovani survival in host macrophages</title><author>Singh, Nisha ; Gedda, Mallikarjuna Rao ; Tiwari, Neeraj ; Singh, Suya P. ; Bajpai, Surabhi ; Singh, Rakesh K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4184-5cac709a634288265b46b81461ba7df95530c01e7270b79b5be93b3e21baf88d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Amphotericin B</topic><topic>Cell activation</topic><topic>control methods</topic><topic>drugs</topic><topic>Health Promotion and Disease Prevention</topic><topic>India</topic><topic>Infectious Diseases</topic><topic>Interleukin 12</topic><topic>Leishmania donovani</topic><topic>Macrophages</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Miltefosine</topic><topic>nitrogen oxides</topic><topic>Original</topic><topic>Original Article</topic><topic>Parasites</topic><topic>people</topic><topic>Phagocytosis</topic><topic>Phagolysosomes</topic><topic>phagosomes</topic><topic>solutes</topic><topic>South East Asia</topic><topic>Survival</topic><topic>tumor necrosis factor-alpha</topic><topic>Visceral leishmaniasis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Singh, Nisha</creatorcontrib><creatorcontrib>Gedda, Mallikarjuna Rao</creatorcontrib><creatorcontrib>Tiwari, Neeraj</creatorcontrib><creatorcontrib>Singh, Suya P.</creatorcontrib><creatorcontrib>Bajpai, Surabhi</creatorcontrib><creatorcontrib>Singh, Rakesh K.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of parasitic diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Singh, Nisha</au><au>Gedda, Mallikarjuna Rao</au><au>Tiwari, Neeraj</au><au>Singh, Suya P.</au><au>Bajpai, Surabhi</au><au>Singh, Rakesh K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Solute carrier protein family 11 member 1 (Slc11a1) activation efficiently inhibits Leishmania donovani survival in host macrophages</atitle><jtitle>Journal of parasitic diseases</jtitle><stitle>J Parasit Dis</stitle><addtitle>J Parasit Dis</addtitle><date>2017-09-01</date><risdate>2017</risdate><volume>41</volume><issue>3</issue><spage>671</spage><epage>677</epage><pages>671-677</pages><issn>0971-7196</issn><eissn>0975-0703</eissn><abstract>Visceral leishmaniasis (kala-azar), a life threatening disease caused by
L. donovani
, is a latent threat to more than 147 million people living in disease endemic South East Asia region of the Indian subcontinent. The therapeutic option to control leishmanial infections are very limited, and at present comprise only two drugs, an antifungal amphotericin B and an antitumor miltefosine, which are also highly vulnerable for parasitic resistance. Therefore, identification and development of alternate control measures is an exigent requirement to control leishmanial infections. In this study, we report that functionally induced expression of solute carrier protein family 11 member 1
(
Slc11a1), a transmembrane divalent cationic transporter recruited on the surface of phagolysosomes after phagocytosis of parasites, effectively inhibits
Leishmania donovani
growth in host macrophages. Further, the increased Slc11a1 functionality also resulted in increased production of NOx, TNF-α and IL-12 by activated macrophages. The findings of this study signify the importance of interplay between Slc11a1 expression and macrophages activation that can be effectively used to control of
Leishmania
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| subjects | Amphotericin B Cell activation control methods drugs Health Promotion and Disease Prevention India Infectious Diseases Interleukin 12 Leishmania donovani Macrophages Medicine Medicine & Public Health Miltefosine nitrogen oxides Original Original Article Parasites people Phagocytosis Phagolysosomes phagosomes solutes South East Asia Survival tumor necrosis factor-alpha Visceral leishmaniasis |
| title | Solute carrier protein family 11 member 1 (Slc11a1) activation efficiently inhibits Leishmania donovani survival in host macrophages |
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