Renoprotective effect of topiroxostat via antioxidant activity in puromycin aminonucleoside nephrosis rats

Topiroxostat is a novel inhibitor of xanthine oxidase, and is postulated to exert a renoprotective effect. Puromycin aminonucleoside nephrosis (PAN) is a rat model of minimal change nephrotic syndrome. In this study, we examined whether topiroxostat ameliorates the kidney injury in PAN rats that was...

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Veröffentlicht in:	Physiological reports 2017-08, Vol.5 (15), p.e13358-n/a
Hauptverfasser:	Kawamorita, Yosuke, Shiraishi, Takeshi, Tamura, Yoshifuru, Kumagai, Takanori, Shibata, Shigeru, Fujigaki, Yoshihide, Hosoyamada, Makoto, Nakagawa, Takahiko, Uchida, Shunya
Format:	Artikel
Sprache:	eng
Schlagworte:	8-Hydroxy-2'-Deoxyguanosine 8-Hydroxydeoxyguanosine Animals Antioxidants - administration & dosage Antioxidants - pharmacology Antioxidants - therapeutic use Body weight Cell culture Cell Line Cell uric acid Deoxyguanosine Deoxyguanosine - analogs & derivatives Deoxyguanosine - metabolism Enzyme Inhibitors - administration & dosage Enzyme Inhibitors - pharmacology Enzyme Inhibitors - therapeutic use Excretion Feet Immunoreactivity Kidney - drug effects Kidney - metabolism Kidneys Male Metabolism and Regulation Mice NAD(P)H oxidase NADPH Oxidase 4 - metabolism Nephrosis - drug therapy Nephrosis - etiology Nephrotic syndrome Nitriles - administration & dosage Nitriles - pharmacology Nitriles - therapeutic use Nitrotyrosine NOX4 NOX4 protein Original Research Oxidative Stress Podocytes - drug effects Podocytes - metabolism Proteinuria Puromycin Puromycin Aminonucleoside - toxicity puromycin aminonucleoside nephrosis Pyridines - administration & dosage Pyridines - pharmacology Pyridines - therapeutic use Rats Rats, Sprague-Dawley Renal Conditions, Disorders and Treatments Renal cortex Renal Filtration Rodents topiroxostat Uric acid Uric Acid - metabolism Xanthine oxidase
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