Haspin inhibition reveals functional differences of interchromatid axis-localized AURKB and AURKC

Aneuploidy is the leading genetic abnormality contributing to infertility, and chromosome segregation errors are common during female mammalian meiosis I (MI). Previous results indicate that haspin kinase regulates resumption of meiosis from prophase arrest, chromosome condensation, and kinetochore-...

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Veröffentlicht in:	Molecular biology of the cell 2017-08, Vol.28 (17), p.2233-2240
Hauptverfasser:	Quartuccio, Suzanne M, Dipali, Shweta S, Schindler, Karen
Format:	Artikel
Sprache:	eng
Schlagworte:	Anaphase Aneuploidy Animals Aurora Kinase B - genetics Aurora Kinase B - metabolism Aurora Kinase C - genetics Aurora Kinase C - metabolism Brief Reports Chromosome Segregation Female Intracellular Signaling Peptides and Proteins - antagonists & inhibitors Intracellular Signaling Peptides and Proteins - genetics Intracellular Signaling Peptides and Proteins - metabolism Kinetochores - metabolism M Phase Cell Cycle Checkpoints - physiology Mad2 Proteins - metabolism Meiosis - physiology Mice Oocytes - metabolism Prometaphase Protein-Serine-Threonine Kinases - antagonists & inhibitors Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - metabolism
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