Parallel homodimer structures of the extracellular domains of the voltage-gated sodium channel β4 subunit explain its role in cell–cell adhesion

Voltage-gated sodium channels (VGSCs) are transmembrane proteins required for the generation of action potentials in excitable cells and essential for propagating electrical impulses along nerve cells. VGSCs are complexes of a pore-forming α subunit and auxiliary β subunits, designated as β1/β1B–β4...

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Veröffentlicht in:	The Journal of biological chemistry 2017-08, Vol.292 (32), p.13428-13440
Hauptverfasser:	Shimizu, Hideaki, Tosaki, Asako, Ohsawa, Noboru, Ishizuka-Katsura, Yoshiko, Shoji, Shisako, Miyazaki, Haruko, Oyama, Fumitaka, Terada, Takaho, Shirouzu, Mikako, Sekine, Shun-ichi, Nukina, Nobuyuki, Yokoyama, Shigeyuki
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Adhesion CHO Cells Cricetulus Crystallography, X-Ray Cysteine - chemistry Cystine - chemistry dimer Dimerization Humans Hydrogen Bonding Hydrophobic and Hydrophilic Interactions immunoglobulin-like domain membrane protein Mice Models, Molecular Navβ4 Peptide Fragments - chemistry Peptide Fragments - genetics Peptide Fragments - metabolism Protein Conformation Protein Conformation, beta-Strand Protein Interaction Domains and Motifs Protein Multimerization Protein Structure and Folding Recombinant Fusion Proteins - chemistry Recombinant Fusion Proteins - metabolism Recombinant Proteins - chemistry Recombinant Proteins - metabolism SCN4B sodium channel Voltage-Gated Sodium Channel beta-4 Subunit - chemistry Voltage-Gated Sodium Channel beta-4 Subunit - genetics Voltage-Gated Sodium Channel beta-4 Subunit - metabolism X-ray crystallography
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