Autophagy downstream of endosomal Toll-like receptor signaling in macrophages is a key mechanism for resistance to Leishmania major infection

Leishmaniasis is caused by protozoan parasites of the genus Leishmania. In mammalians, these parasites survive and replicate in macrophages and parasite elimination by macrophages is critical for host resistance. Endosomal Toll-like receptors (TLRs) have been shown to be crucial for resistance to Le...

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Veröffentlicht in:	The Journal of biological chemistry 2017-08, Vol.292 (32), p.13087-13096
Hauptverfasser:	Franco, Luis H., Fleuri, Anna K.A., Pellison, Natália C., Quirino, Gustavo F.S., Horta, Catarina V., de Carvalho, Renan V.H., Oliveira, Sérgio C., Zamboni, Dario S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Autophagy Autophagy-Related Protein 5 - antagonists & inhibitors Autophagy-Related Protein 5 - genetics Autophagy-Related Protein 5 - metabolism Bone Marrow Cells - immunology Bone Marrow Cells - metabolism Bone Marrow Cells - parasitology Bone Marrow Cells - pathology Cells, Cultured Disease Resistance Endosomes - immunology Endosomes - metabolism Endosomes - parasitology Endosomes - pathology Female Immunology infection Leishmania Leishmania major - growth & development Leishmania major - immunology Leishmania major - physiology Leishmaniasis, Cutaneous - immunology Leishmaniasis, Cutaneous - metabolism Leishmaniasis, Cutaneous - parasitology Leishmaniasis, Cutaneous - pathology macrophage Macrophages - immunology Macrophages - metabolism Macrophages - parasitology Macrophages - pathology Male Membrane Glycoproteins - genetics Membrane Glycoproteins - metabolism Membrane Transport Proteins - genetics Membrane Transport Proteins - metabolism Mice, Inbred C57BL Mice, Knockout Myeloid Differentiation Factor 88 - genetics Myeloid Differentiation Factor 88 - metabolism RNA Interference Signal Transduction toll-like receptor (TLR) Toll-Like Receptor 3 - genetics Toll-Like Receptor 3 - metabolism Toll-Like Receptor 7 - genetics Toll-Like Receptor 7 - metabolism Toll-Like Receptor 9 - genetics Toll-Like Receptor 9 - metabolism
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