Evaluation of Oxetan-3-ol, Thietan-3-ol, and Derivatives Thereof as Bioisosteres of the Carboxylic Acid Functional Group

The oxetane ring serves as an isostere of the carbonyl moiety, suggesting that oxetan-3-ol may be considered as a potential surrogate of the carboxylic acid functional group. To investigate this structural unit, as well as thietan-3-ol and the corresponding sulfoxide and sulfone derivatives, as pote...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	ACS medicinal chemistry letters 2017-08, Vol.8 (8), p.864-868
Hauptverfasser:	Lassalas, Pierrik, Oukoloff, Killian, Makani, Vishruti, James, Michael, Tran, Van, Yao, Yuemang, Huang, Longchuan, Vijayendran, Krishna, Monti, Ludovica, Trojanowski, John Q, Lee, Virginia M.-Y, Kozlowski, Marisa C, Smith, Amos B, Brunden, Kurt R, Ballatore, Carlo
Format:	Artikel
Sprache:	eng
Schlagworte:	Letter
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!