Genome-wide Regional Heritability Mapping Identifies a Locus Within the TOX2 Gene Associated With Major Depressive Disorder

Abstract Background Major depressive disorder (MDD) is the second largest cause of global disease burden. It has an estimated heritability of 37%, but published genome-wide association studies have so far identified few risk loci. Haplotype-block-based regional heritability mapping (HRHM) estimates...

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Veröffentlicht in:	Biological psychiatry (1969) 2017-09, Vol.82 (5), p.312-321
Hauptverfasser:	Zeng, Yanni, Navarro, Pau, Shirali, Masoud, Howard, David M, Adams, Mark J, Hall, Lynsey S, Clarke, Toni-Kim, Thomson, Pippa A, Smith, Blair H, Murray, Alison, Padmanabhan, Sandosh, Hayward, Caroline, Boutin, Thibaud, MacIntyre, Donald J, Lewis, Cathryn M, Wray, Naomi R, Mehta, Divya, Penninx, Brenda W.J.H, Milaneschi, Yuri, Baune, Bernhard T, Air, Tracy, Hottenga, Jouke-Jan, Mbarek, Hamdi, Castelao, Enrique, Pistis, Giorgio, Schulze, Thomas G, Streit, Fabian, Forstner, Andreas J, Byrne, Enda M, Martin, Nicholas G, Breen, Gerome, Müller-Myhsok, Bertram, Lucae, Susanne, Kloiber, Stefan, Domenici, Enrico, Deary, Ian J, Porteous, David J, Haley, Chris S, McIntosh, Andrew M
Format:	Artikel
Sprache:	eng
Schlagworte:	Cohort Studies Depressive Disorder, Major - genetics Female Genetic Loci Genetic Predisposition to Disease Genome-wide analyses Genome-Wide Association Study Haplotype block Haplotypes HMGB Proteins - genetics HRHM Humans Ireland Male MDD Middle Aged Polymorphism, Single Nucleotide Priority Communication Psychiatry Regional heritability TOX2 United Kingdom
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