Novel in vitro booster vaccination to rapidly generate antigen-specific human monoclonal antibodies

Vaccines remain the most effective tool to prevent infectious diseases. Here, we introduce an in vitro booster vaccination approach that relies on antigen-dependent activation of human memory B cells in culture. This stimulation induces antigen-specific B cell proliferation, differentiation of B cel...

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Veröffentlicht in:	The Journal of experimental medicine 2017-08, Vol.214 (8), p.2471-2490
Hauptverfasser:	Sanjuan Nandin, Irene, Fong, Carol, Deantonio, Cecilia, Torreno-Pina, Juan A, Pecetta, Simone, Maldonado, Paula, Gasparrini, Francesca, Ordovas-Montanes, Jose, Kazer, Samuel W, Kjaer, Svend, Borley, Daryl W, Nair, Usha, Coleman, Julia A, Lingwood, Daniel, Shalek, Alex K, Meffre, Eric, Poignard, Pascal, Burton, Dennis R, Batista, Facundo D
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens Cell activation Cell culture Cell proliferation Glycoprotein gp120 HIV Human immunodeficiency virus Immunization Immunogenicity Immunoglobulins Immunological memory Infectious diseases Influenza Lymphocytes B Memory cells Monoclonal antibodies Plasma cells Tetanus Vaccine development Vaccines
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