The neurovascular unit and the pathophysiologic basis of diabetic retinopathy
Purpose To relate the concept of the retinal neurovascular unit and its alterations in diabetes to the pathophysiology of diabetic retinopathy. Methods Case illustrations and conceptual frameworks are presented that illustrate adaptive and maladaptive “dis-integration” of the retinal neurovascular u...
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| Veröffentlicht in: | Graefe's archive for clinical and experimental ophthalmology 2017-01, Vol.255 (1), p.1-6 |
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| container_title | Graefe's archive for clinical and experimental ophthalmology |
| container_volume | 255 |
| creator | Gardner, Thomas W. Davila, Jose R. |
| description | Purpose
To relate the concept of the retinal neurovascular unit and its alterations in diabetes to the pathophysiology of diabetic retinopathy.
Methods
Case illustrations and conceptual frameworks are presented that illustrate adaptive and maladaptive “dis-integration” of the retinal neurovascular unit with the progression of diabetes.
Results
Retinopathy treatment should address pathophysiologic processes rather than pathologic lesions as is current practice.
Conclusions
Future improvements in the treatment of diabetic retinopathy requires deeper understanding of the cellular and molecular changes induced by diabetes, coupled with the use of quantitative phenotyping methods that assess the pathophysiologic processes. |
| doi_str_mv | 10.1007/s00417-016-3548-y |
| format | Article |
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To relate the concept of the retinal neurovascular unit and its alterations in diabetes to the pathophysiology of diabetic retinopathy.
Methods
Case illustrations and conceptual frameworks are presented that illustrate adaptive and maladaptive “dis-integration” of the retinal neurovascular unit with the progression of diabetes.
Results
Retinopathy treatment should address pathophysiologic processes rather than pathologic lesions as is current practice.
Conclusions
Future improvements in the treatment of diabetic retinopathy requires deeper understanding of the cellular and molecular changes induced by diabetes, coupled with the use of quantitative phenotyping methods that assess the pathophysiologic processes.</description><identifier>ISSN: 0721-832X</identifier><identifier>EISSN: 1435-702X</identifier><identifier>DOI: 10.1007/s00417-016-3548-y</identifier><identifier>PMID: 27832340</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Diabetic retinopathy ; Diabetic Retinopathy - complications ; Diabetic Retinopathy - diagnosis ; Disease Progression ; Humans ; Medicine ; Medicine & Public Health ; Ophthalmology ; Retina - pathology ; Retinal Neovascularization - diagnosis ; Retinal Neovascularization - etiology ; Review Article ; Tomography, Optical Coherence - methods</subject><ispartof>Graefe's archive for clinical and experimental ophthalmology, 2017-01, Vol.255 (1), p.1-6</ispartof><rights>Springer-Verlag Berlin Heidelberg 2016</rights><rights>Graefe's Archive for Clinical and Experimental Ophthalmology is a copyright of Springer, 2017.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c569t-33a8a050325ae97846a06afce984ac7a021d0e9aba83bcc5057a688d163673433</citedby><cites>FETCH-LOGICAL-c569t-33a8a050325ae97846a06afce984ac7a021d0e9aba83bcc5057a688d163673433</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00417-016-3548-y$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00417-016-3548-y$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,313,314,776,780,788,881,27899,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27832340$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gardner, Thomas W.</creatorcontrib><creatorcontrib>Davila, Jose R.</creatorcontrib><title>The neurovascular unit and the pathophysiologic basis of diabetic retinopathy</title><title>Graefe's archive for clinical and experimental ophthalmology</title><addtitle>Graefes Arch Clin Exp Ophthalmol</addtitle><addtitle>Graefes Arch Clin Exp Ophthalmol</addtitle><description>Purpose
To relate the concept of the retinal neurovascular unit and its alterations in diabetes to the pathophysiology of diabetic retinopathy.
Methods
Case illustrations and conceptual frameworks are presented that illustrate adaptive and maladaptive “dis-integration” of the retinal neurovascular unit with the progression of diabetes.
Results
Retinopathy treatment should address pathophysiologic processes rather than pathologic lesions as is current practice.
Conclusions
Future improvements in the treatment of diabetic retinopathy requires deeper understanding of the cellular and molecular changes induced by diabetes, coupled with the use of quantitative phenotyping methods that assess the pathophysiologic processes.</description><subject>Diabetic retinopathy</subject><subject>Diabetic Retinopathy - complications</subject><subject>Diabetic Retinopathy - diagnosis</subject><subject>Disease Progression</subject><subject>Humans</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Ophthalmology</subject><subject>Retina - pathology</subject><subject>Retinal Neovascularization - diagnosis</subject><subject>Retinal Neovascularization - etiology</subject><subject>Review Article</subject><subject>Tomography, Optical Coherence - methods</subject><issn>0721-832X</issn><issn>1435-702X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqNkU1r3DAQhkVpaLZpf0AvxdBLL25GHuvDl0IJ_YKEXlLITYxl7a6CV9pKdsD_vlo2DWmhkIsE8z7zzkgvY284fOAA6jwDtFzVwGWNotX18oyteIuiVtDcPGcrUA2vNTY3p-xlzrdQcBT8BTttVKliCyt2db11VXBzineU7TxSqubgp4rCUE1F2tO0jfvtkn0c48bbqqfscxXX1eCpd1OppHKGeACXV-xkTWN2r-_vM_bzy-fri2_15Y-v3y8-XdZWyG6qEUkTCMBGkOuUbiWBpLV1nW7JKoKGD-A66kljb60AoUhqPXCJUmGLeMY-Hn33c79zg3VhSjSaffI7SouJ5M3fSvBbs4l3RgjBy9xi8P7eIMVfs8uT2fls3ThScHHOhmupESXy5gkodpwryXlB3_2D3sY5hfIThRIt6k4CFIofKZtizsmtH_bmYA65mmOupuRqDrmapfS8ffzgh44_QRagOQK5SGHj0qPR_3X9DfCOrsQ</recordid><startdate>20170101</startdate><enddate>20170101</enddate><creator>Gardner, Thomas W.</creator><creator>Davila, Jose R.</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20170101</creationdate><title>The neurovascular unit and the pathophysiologic basis of diabetic retinopathy</title><author>Gardner, Thomas W. ; Davila, Jose R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c569t-33a8a050325ae97846a06afce984ac7a021d0e9aba83bcc5057a688d163673433</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Diabetic retinopathy</topic><topic>Diabetic Retinopathy - complications</topic><topic>Diabetic Retinopathy - diagnosis</topic><topic>Disease Progression</topic><topic>Humans</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Ophthalmology</topic><topic>Retina - pathology</topic><topic>Retinal Neovascularization - diagnosis</topic><topic>Retinal Neovascularization - etiology</topic><topic>Review Article</topic><topic>Tomography, Optical Coherence - methods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gardner, Thomas W.</creatorcontrib><creatorcontrib>Davila, Jose R.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Central (New)</collection><collection>ProQuest One Academic (New)</collection><collection>ProQuest Health & Medical Research Collection</collection><collection>ProQuest One Academic Middle East (New)</collection><collection>ProQuest One Health & Nursing</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Graefe's archive for clinical and experimental ophthalmology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gardner, Thomas W.</au><au>Davila, Jose R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The neurovascular unit and the pathophysiologic basis of diabetic retinopathy</atitle><jtitle>Graefe's archive for clinical and experimental ophthalmology</jtitle><stitle>Graefes Arch Clin Exp Ophthalmol</stitle><addtitle>Graefes Arch Clin Exp Ophthalmol</addtitle><date>2017-01-01</date><risdate>2017</risdate><volume>255</volume><issue>1</issue><spage>1</spage><epage>6</epage><pages>1-6</pages><issn>0721-832X</issn><eissn>1435-702X</eissn><abstract>Purpose
To relate the concept of the retinal neurovascular unit and its alterations in diabetes to the pathophysiology of diabetic retinopathy.
Methods
Case illustrations and conceptual frameworks are presented that illustrate adaptive and maladaptive “dis-integration” of the retinal neurovascular unit with the progression of diabetes.
Results
Retinopathy treatment should address pathophysiologic processes rather than pathologic lesions as is current practice.
Conclusions
Future improvements in the treatment of diabetic retinopathy requires deeper understanding of the cellular and molecular changes induced by diabetes, coupled with the use of quantitative phenotyping methods that assess the pathophysiologic processes.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>27832340</pmid><doi>10.1007/s00417-016-3548-y</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0721-832X |
| ispartof | Graefe's archive for clinical and experimental ophthalmology, 2017-01, Vol.255 (1), p.1-6 |
| issn | 0721-832X 1435-702X |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5551503 |
| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Diabetic retinopathy Diabetic Retinopathy - complications Diabetic Retinopathy - diagnosis Disease Progression Humans Medicine Medicine & Public Health Ophthalmology Retina - pathology Retinal Neovascularization - diagnosis Retinal Neovascularization - etiology Review Article Tomography, Optical Coherence - methods |
| title | The neurovascular unit and the pathophysiologic basis of diabetic retinopathy |
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