Dendritic Architecture of Principal Basolateral Amygdala Neurons Changes Congruently with Endocrine Response to Stress
Animals cope with changing environments through changes in behavior. Such plasticity is, however, marked by substantial inter-individual variability. Neuroendocrine reactivity to challenging environments can be an important predictor of resilience. Both basolateral amygdala (BLA) neurons and adrenal...
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| Veröffentlicht in: | International journal of environmental research and public health 2017-07, Vol.14 (7), p.779 |
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| creator | Hegde, Akshaya Soh Yee, Poh Mitra, Rupshi |
| description | Animals cope with changing environments through changes in behavior. Such plasticity is, however, marked by substantial inter-individual variability. Neuroendocrine reactivity to challenging environments can be an important predictor of resilience. Both basolateral amygdala (BLA) neurons and adrenal glucocorticoid signaling are integral parts of the stress neuroendocrine response. In this report, we test if individual variation in hormonal response to stress is associated with individual variation in the dendritic complexity of BLA neurons. We report a positive correlation between inter-individual variability in glucocorticoid response and neuronal plasticity in the BLA subsequent to a stressor. This suggests that stressful experiences in the past act as significant sculptors of BLA neuronal plasticity and congruent neuroendocrine response. |
| doi_str_mv | 10.3390/ijerph14070779 |
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Such plasticity is, however, marked by substantial inter-individual variability. Neuroendocrine reactivity to challenging environments can be an important predictor of resilience. Both basolateral amygdala (BLA) neurons and adrenal glucocorticoid signaling are integral parts of the stress neuroendocrine response. In this report, we test if individual variation in hormonal response to stress is associated with individual variation in the dendritic complexity of BLA neurons. We report a positive correlation between inter-individual variability in glucocorticoid response and neuronal plasticity in the BLA subsequent to a stressor. This suggests that stressful experiences in the past act as significant sculptors of BLA neuronal plasticity and congruent neuroendocrine response.</description><identifier>ISSN: 1660-4601</identifier><identifier>ISSN: 1661-7827</identifier><identifier>EISSN: 1660-4601</identifier><identifier>DOI: 10.3390/ijerph14070779</identifier><identifier>PMID: 28708076</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Amygdala ; Animals ; Anxiety ; Anxiety - metabolism ; Basolateral Nuclear Complex - physiopathology ; Brain ; Changing environments ; Corticosterone - metabolism ; Dendrites - physiology ; Gene expression ; Glucocorticoids - metabolism ; Hormones ; Hypotheses ; Male ; Morphology ; Neuronal Plasticity - physiology ; Neurons ; Neuroplasticity ; Neurosciences ; Rats ; Rats, Wistar ; Rodents ; Stress ; Stress, Physiological ; Urine ; Variability</subject><ispartof>International journal of environmental research and public health, 2017-07, Vol.14 (7), p.779</ispartof><rights>2017. This work is licensed under http://creativecommons.org/licenses/by/3.0/ (the “License”). 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Such plasticity is, however, marked by substantial inter-individual variability. Neuroendocrine reactivity to challenging environments can be an important predictor of resilience. Both basolateral amygdala (BLA) neurons and adrenal glucocorticoid signaling are integral parts of the stress neuroendocrine response. In this report, we test if individual variation in hormonal response to stress is associated with individual variation in the dendritic complexity of BLA neurons. We report a positive correlation between inter-individual variability in glucocorticoid response and neuronal plasticity in the BLA subsequent to a stressor. This suggests that stressful experiences in the past act as significant sculptors of BLA neuronal plasticity and congruent neuroendocrine response.</description><subject>Amygdala</subject><subject>Animals</subject><subject>Anxiety</subject><subject>Anxiety - metabolism</subject><subject>Basolateral Nuclear Complex - physiopathology</subject><subject>Brain</subject><subject>Changing environments</subject><subject>Corticosterone - metabolism</subject><subject>Dendrites - physiology</subject><subject>Gene expression</subject><subject>Glucocorticoids - metabolism</subject><subject>Hormones</subject><subject>Hypotheses</subject><subject>Male</subject><subject>Morphology</subject><subject>Neuronal Plasticity - physiology</subject><subject>Neurons</subject><subject>Neuroplasticity</subject><subject>Neurosciences</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Rodents</subject><subject>Stress</subject><subject>Stress, Physiological</subject><subject>Urine</subject><subject>Variability</subject><issn>1660-4601</issn><issn>1661-7827</issn><issn>1660-4601</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNpdkc1r3DAQxUVJaZJtrz0GQS69bCpZsixdAtttPgqhLf04C1ker7V4JVeSE_a_r0LSkPQ0D-Y3j3k8hN5TcsaYIh_dFuI0UE4a0jTqFTqiQpAlF4QePNOH6DilLSFMcqHeoMNKNkSSRhyh28_gu-iys3gV7eAy2DxHwKHH36Pz1k1mxJ9MCqPJEIte7fabzowGf4U5Bp_wejB-A2UGv4kz-Dzu8Z3LA77wXbDFA_APSFNBAeeAf-YIKb1Fr3szJnj3OBfo9-XFr_X18ubb1Zf16mZpOZV5KXjbmaqXYFhrKROVpdC1orOqkbQ2VLCu76URxDQg61ZJAX1rleIK6sJYtkDnD77T3O6gs-W9EkJP0e1M3OtgnH658W7Qm3Cr67qmFW2KwYdHgxj-zJCy3rlkYRyNhzAnTVVFqGK8YgU9_Q_dhjn6Ek9XlEhOeV3IBTp7oGwMKUXon56hRN9Xql9WWg5Onkd4wv91yP4C_oShTA</recordid><startdate>20170714</startdate><enddate>20170714</enddate><creator>Hegde, Akshaya</creator><creator>Soh Yee, Poh</creator><creator>Mitra, Rupshi</creator><general>MDPI AG</general><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20170714</creationdate><title>Dendritic Architecture of Principal Basolateral Amygdala Neurons Changes Congruently with Endocrine Response to Stress</title><author>Hegde, Akshaya ; 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| subjects | Amygdala Animals Anxiety Anxiety - metabolism Basolateral Nuclear Complex - physiopathology Brain Changing environments Corticosterone - metabolism Dendrites - physiology Gene expression Glucocorticoids - metabolism Hormones Hypotheses Male Morphology Neuronal Plasticity - physiology Neurons Neuroplasticity Neurosciences Rats Rats, Wistar Rodents Stress Stress, Physiological Urine Variability |
| title | Dendritic Architecture of Principal Basolateral Amygdala Neurons Changes Congruently with Endocrine Response to Stress |
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