BAG3 promotes stem cell-like phenotype in breast cancer by upregulation of CXCR4 via interaction with its transcript

BAG3 is an evolutionarily conserved co-chaperone expressed at high levels and has a prosurvival role in many tumor types. The current study reported that BAG3 was induced under specific floating culture conditions that enrich breast cancer stem cell (BCSC)-like cells in spheres. Ectopic BAG3 overexp...

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Veröffentlicht in:	Cell death & disease 2017-07, Vol.8 (7), p.e2933-e2933
Hauptverfasser:	Liu, Bao-Qin, Zhang, Song, Li, Si, An, Ming-Xin, Li, Chao, Yan, Jing, Wang, Jia-Mei, Wang, Hua-Qin
Format:	Artikel
Sprache:	eng
Schlagworte:	38 38/109 631/80/86 692/699/67/1059/602 692/699/67/1347 692/700/1750 82 82/80 96 96/100 Adaptor Proteins, Signal Transducing - deficiency Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - metabolism Antibodies Apoptosis Regulatory Proteins - deficiency Apoptosis Regulatory Proteins - genetics Apoptosis Regulatory Proteins - metabolism Biochemistry Biomedical and Life Sciences Breast cancer Breast Neoplasms - metabolism Breast Neoplasms - mortality Breast Neoplasms - pathology CD44 antigen Cell Biology Cell Culture Cell Line, Tumor Cell Self Renewal Cellular biology CRISPR-Cas Systems - genetics CXCR4 protein Female Gene expression Genotype & phenotype Half-Life Heterocyclic Compounds - pharmacology Humans Immunology Kaplan-Meier Estimate Life Sciences MCF-7 Cells Nanog Homeobox Protein - genetics Nanog Homeobox Protein - metabolism Neoplastic Stem Cells - cytology Neoplastic Stem Cells - metabolism Original original-article Phenotype Post-transcription Prognosis Proportional Hazards Models Receptors, CXCR4 - genetics Receptors, CXCR4 - metabolism SOXB1 Transcription Factors - genetics SOXB1 Transcription Factors - metabolism Stem cells Transcription Up-Regulation - drug effects
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