Killing two birds with one stone: dual blockade of integrin and FGF signaling through targeting syndecan-4 in postoperative capsular opacification

The most common complication after cataract surgery is postoperative capsular opacification, which includes anterior capsular opacification (ACO) and posterior capsular opacification (PCO). Increased adhesion of lens epithelial cells (LECs) to the intraocular lens material surface promotes ACO forma...

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Veröffentlicht in:	Cell death & disease 2017-07, Vol.8 (7), p.e2920-e2920
Hauptverfasser:	Qin, Yingyan, Zhu, Yi, Luo, Furong, Chen, Chuan, Chen, Xiaoyun, Wu, Mingxing
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase 13/21 13/89 14/19 38/77 45/90 631/80/86 692/699/3161/3168 692/700/565/1436/2185 692/700/565/545 82/80 96/35 96/95 Age AKT protein Animals Anterior Chamber - metabolism Anterior Chamber - pathology Antibodies Biochemistry Capsule Opacification - metabolism Capsule Opacification - pathology Capsule Opacification - surgery Cataracts Cell activation Cell adhesion Cell adhesion & migration Cell Adhesion - drug effects Cell Biology Cell Culture Cell growth Cell Line Cell Movement - drug effects Cell proliferation Cell Proliferation - drug effects Disease Models, Animal Epithelial cells Epithelial Cells - cytology Epithelial Cells - metabolism Extracellular matrix Extracellular signal-regulated kinase Eye surgery Fibroblast Growth Factor 2 - pharmacology Fibroblast growth factors Focal adhesion kinase G1 Phase Cell Cycle Checkpoints - drug effects Humans Immunology Integrins - metabolism Kinases Lens, Crystalline - cytology Life Sciences Mice Mice, Knockout Original original-article Phosphorylation Postoperative period Protein Kinases - metabolism Retina - metabolism Retina - pathology RNA Interference Signal transduction Signal Transduction - drug effects Surgery Syndecan Syndecan-4 - antagonists & inhibitors Syndecan-4 - genetics Syndecan-4 - metabolism TOR protein
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