Pre-synaptic TrkB in basolateral amygdala neurons mediates BDNF signaling transmission in memory extinction

Brain-derived neurotrophic factor (BDNF) and its high affinity receptor, TrkB, play an essential role in memory extinction. Our previous work has shown that JIP3 (JNK interacted protein 3) mediates anterograde axonal transport of TrkB through the direct binding of its coiled-coil domain 1 (CC1) with...

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Veröffentlicht in:	Cell death & disease 2017-07, Vol.8 (7), p.e2959-e2959
Hauptverfasser:	Li, Yuan, Wang, Dongdong, Li, Yang, Chu, Hongxia, Zhang, Lining, Hou, Ming, Jiang, Xingyu, Chen, Zheyu, Su, Bo, Sun, Tao
Format:	Artikel
Sprache:	eng
Schlagworte:	101/62 13/109 13/51 14/19 14/35 14/56 631/378/1457/1284 631/378/1595 631/378/340 631/80/86 Amygdala Animals Antibodies Axonal transport Basolateral Nuclear Complex - cytology Basolateral Nuclear Complex - metabolism Biochemistry Biomedical and Life Sciences Brain-derived neurotrophic factor Brain-Derived Neurotrophic Factor - metabolism Cell Biology Cell Culture Cells, Cultured Extinction behavior Fluorescent Antibody Technique Fused protein Green fluorescent protein Green Fluorescent Proteins - genetics Green Fluorescent Proteins - metabolism HEK293 Cells Humans Immunohistochemistry Immunology Immunoprecipitation JNK protein Life Sciences Localization Male Memory Memory - physiology Neurobiology Neurons Neurons - metabolism Original original-article Phosphorylation Prefrontal cortex Rats Rats, Wistar Receptor, trkB - metabolism Signal transduction Signal Transduction - physiology TrkB receptors
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