miR-181d and c-myc-mediated inhibition of CRY2 and FBXL3 reprograms metabolism in colorectal cancer

Colorectal cancer (CRC) is the second major cause of tumor-related deaths. MicroRNAs (miRNAs) have pivotal roles in CRC progression. Here, we describe the effect of miR-181d on CRC cell metabolism and underlying molecular mechanism. Our data firmly demonstrated that knockdown of miR-181d suppressed...

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Veröffentlicht in:	Cell death & disease 2017-07, Vol.8 (7), p.e2958-e2958
Hauptverfasser:	Guo, Xiaofeng, Zhu, Yuekun, Hong, Xinya, Zhang, Mukun, Qiu, Xingfeng, Wang, Zhenfa, Qi, Zhongquan, Hong, Xuehui
Format:	Artikel
Sprache:	eng
Schlagworte:	14 38 631/337/384/331 631/80/86 64/60 692/699/67/1504/1885 692/699/67/2327 Animals Antibodies Biochemistry Biomedical and Life Sciences Blotting, Western c-Myc protein Caco-2 Cells Cell Biology Cell Culture Cell Line, Tumor Cell Movement - genetics Cell Movement - physiology Cell proliferation Cell Proliferation - genetics Cell Proliferation - physiology Chromatin Immunoprecipitation Colorectal cancer Colorectal carcinoma Colorectal Neoplasms - genetics Colorectal Neoplasms - metabolism Cryptochromes - genetics Cryptochromes - metabolism F-Box Proteins - genetics F-Box Proteins - metabolism Feedback Female Gene expression Gene Expression Regulation, Neoplastic - genetics Gene Expression Regulation, Neoplastic - physiology Glucose Glycolysis HCT116 Cells HT29 Cells Humans Immunology Kinases Lactic acid Life Sciences Metabolism Metastases Mice Mice, Inbred BALB C MicroRNAs MicroRNAs - genetics MicroRNAs - metabolism miRNA Myc protein Original original-article Promoters Proto-Oncogene Proteins c-myc - genetics Proto-Oncogene Proteins c-myc - metabolism RNA Stability - genetics RNA Stability - physiology RNA, Messenger - genetics RNA, Messenger - metabolism siRNA Transcription
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