Buparlisib plus fulvestrant versus placebo plus fulvestrant in postmenopausal, hormone receptor-positive, HER2-negative, advanced breast cancer (BELLE-2): a randomised, double-blind, placebo-controlled, phase 3 trial

Summary Background Phosphatidylinositol 3-kinase (PI3K) pathway activation is a hallmark of endocrine therapy-resistant, hormone receptor-positive breast cancer. This phase 3 study assessed the efficacy of the pan-PI3K inhibitor buparlisib plus fulvestrant in patients with advanced breast cancer, in...

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Veröffentlicht in:	The lancet oncology 2017-07, Vol.18 (7), p.904-916
Hauptverfasser:	Baselga, José, Prof, Im, Seock-Ah, Prof, Iwata, Hiroji, MD, Cortés, Javier, MD, De Laurentiis, Michele, MD, Jiang, Zefei, Prof, Arteaga, Carlos L, Prof, Jonat, Walter, Prof, Clemons, Mark, Prof, Ito, Yoshinori, MD, Awada, Ahmad, Prof, Chia, Stephen, MD, Jagiełło-Gruszfeld, Agnieszka, MD, Pistilli, Barbara, MD, Tseng, Ling-Ming, MD, Hurvitz, Sara, MD, Masuda, Norikazu, MD, Takahashi, Masato, MD, Vuylsteke, Peter, MD, Hachemi, Soulef, PhD, Dharan, Bharani, MS, Di Tomaso, Emmanuelle, PhD, Urban, Patrick, MD, Massacesi, Cristian, MD, Campone, Mario, Prof
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase Aged Alanine Alanine transaminase Alanine Transaminase - blood Aminopyridines - administration & dosage Aminopyridines - adverse effects Anticoagulants Antineoplastic Combined Chemotherapy Protocols - adverse effects Antineoplastic Combined Chemotherapy Protocols - therapeutic use Aromatase Aspartate aminotransferase Aspartate Aminotransferases - blood Biomarkers, Tumor - genetics Breast cancer Breast Neoplasms - chemistry Breast Neoplasms - drug therapy Breast Neoplasms - genetics Breast Neoplasms - pathology Cancer therapies Chemotherapy Class I Phosphatidylinositol 3-Kinases Clinical trials Disease-Free Survival DNA Mutational Analysis DNA, Neoplasm - blood Double-Blind Method Double-blind studies Drug Eruptions - etiology Endocrine therapy Epidermal growth factor ErbB-2 protein Estradiol - administration & dosage Estradiol - analogs & derivatives Estrogens Exanthema Exanthema - chemically induced Female Fulvestrant Hematology, Oncology and Palliative Medicine Humans Hyperglycemia - chemically induced Metastases Metastasis Middle Aged Morpholines - administration & dosage Morpholines - adverse effects Motivation Mutation Neoplasm Metastasis Phosphatidylinositol 3-Kinases - genetics Post-menopause Postmenopause Receptor, ErbB-2 - analysis Receptors, Estrogen - analysis Receptors, Progesterone - analysis Response Evaluation Criteria in Solid Tumors Retreatment Signal Transduction - genetics Solid tumors Survival Survival Rate Toxicity Tumors Womens health
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