Clinical value of integrated‐signature miRNAs in esophageal cancer
MicroRNAs (miRNAs) are crucial regulators of gene expression in tumorigenesis and are of great interest to researchers, but miRNA profiles are often inconsistent between studies. The aim of this study was to confirm candidate miRNA biomarkers for esophageal cancer from integrated‐miRNA expression pr...
Gespeichert in:
| Veröffentlicht in: | Cancer medicine (Malden, MA) MA), 2017-08, Vol.6 (8), p.1893-1903 |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1903 |
|---|---|
| container_issue | 8 |
| container_start_page | 1893 |
| container_title | Cancer medicine (Malden, MA) |
| container_volume | 6 |
| creator | Zhang, Heng‐Chao Tang, Kai‐Fu |
| description | MicroRNAs (miRNAs) are crucial regulators of gene expression in tumorigenesis and are of great interest to researchers, but miRNA profiles are often inconsistent between studies. The aim of this study was to confirm candidate miRNA biomarkers for esophageal cancer from integrated‐miRNA expression profiling data and TCGA (The Cancer Genome Atlas) data in tissues. Here, we identify five significant miRNAs by a comprehensive analysis in esophageal cancer, and two of them (hsa‐miR‐100‐5p and hsa‐miR‐133b) show better prognoses with significant difference for both 3‐year and 5‐year survival. Additionally, they participate in esophageal cancer occurrence and development according to KEGG and Panther enrichment analyses. Therefore, these five miRNAs may serve as miRNA biomarkers in esophageal cancer. Analysis of differential expression for target genes of these miRNAs may also provide new therapeutic alternatives in esophageal cancer. |
| doi_str_mv | 10.1002/cam4.1129 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5548877</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1920204068</sourcerecordid><originalsourceid>FETCH-LOGICAL-p3419-33ad56735e1f1e0994909d0e6b769ca4bda4dfbe03fd79ef2d609f64c109791e3</originalsourceid><addsrcrecordid>eNpVUctOwzAQtBCIVqUHfgDlyCWtHTt2fEGqwlMqICE4W06ySY3yIk6KeuMT-Ea-hEQtVdnLrjSzM9IMQucEzwjG3jzWBZsR4skjNPYw813BKTs-uEdoau077kdgjwtyikZeILBgvhij6zA3pYl17qx13oFTpY4pW8ga3ULy8_VtTVbqtmvAKczL08L2qAO2qlc6g_4p1mUMzRk6SXVuYbrbE_R2e_Ma3rvL57uHcLF0a8qIdCnVic8F9YGkBLCUTGKZYOCR4DLWLEo0S9IIME0TISH1Eo5lyllMsBSSAJ2gq61u3UUFJDGUbaNzVTem0M1GVdqo_0hpViqr1sr3WRAI0Qtc7gSa6qMD26rC2BjyXJdQdVYR6eE-N8yDnnpx6LU3-YuuJ8y3hE-Tw2aPE6yGWtRQixpqUeHikQ0H_QXOTYCl</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1920204068</pqid></control><display><type>article</type><title>Clinical value of integrated‐signature miRNAs in esophageal cancer</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Access via Wiley Online Library</source><source>Wiley Online Library (Open Access Collection)</source><source>PubMed Central</source><creator>Zhang, Heng‐Chao ; Tang, Kai‐Fu</creator><creatorcontrib>Zhang, Heng‐Chao ; Tang, Kai‐Fu</creatorcontrib><description>MicroRNAs (miRNAs) are crucial regulators of gene expression in tumorigenesis and are of great interest to researchers, but miRNA profiles are often inconsistent between studies. The aim of this study was to confirm candidate miRNA biomarkers for esophageal cancer from integrated‐miRNA expression profiling data and TCGA (The Cancer Genome Atlas) data in tissues. Here, we identify five significant miRNAs by a comprehensive analysis in esophageal cancer, and two of them (hsa‐miR‐100‐5p and hsa‐miR‐133b) show better prognoses with significant difference for both 3‐year and 5‐year survival. Additionally, they participate in esophageal cancer occurrence and development according to KEGG and Panther enrichment analyses. Therefore, these five miRNAs may serve as miRNA biomarkers in esophageal cancer. Analysis of differential expression for target genes of these miRNAs may also provide new therapeutic alternatives in esophageal cancer.</description><identifier>ISSN: 2045-7634</identifier><identifier>EISSN: 2045-7634</identifier><identifier>DOI: 10.1002/cam4.1129</identifier><identifier>PMID: 28707457</identifier><language>eng</language><publisher>United States: John Wiley and Sons Inc</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Biomarkers, Tumor ; Clinical Cancer Research ; Computational Biology - methods ; Databases, Genetic ; Enrichment analysis ; esophageal cancer ; Esophageal Neoplasms - diagnosis ; Esophageal Neoplasms - genetics ; Esophageal Neoplasms - mortality ; Female ; Gene Expression Profiling ; Gene Expression Regulation, Neoplastic ; Humans ; Male ; MicroRNAs - genetics ; Middle Aged ; Molecular Sequence Annotation ; Original Research ; Prognosis ; Transcriptome ; Young Adult</subject><ispartof>Cancer medicine (Malden, MA), 2017-08, Vol.6 (8), p.1893-1903</ispartof><rights>2017 The Authors. published by John Wiley & Sons Ltd.</rights><rights>2017 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><orcidid>0000-0002-1672-1596</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5548877/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5548877/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,729,782,786,866,887,1419,11569,27931,27932,45581,45582,46059,46483,53798,53800</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28707457$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, Heng‐Chao</creatorcontrib><creatorcontrib>Tang, Kai‐Fu</creatorcontrib><title>Clinical value of integrated‐signature miRNAs in esophageal cancer</title><title>Cancer medicine (Malden, MA)</title><addtitle>Cancer Med</addtitle><description>MicroRNAs (miRNAs) are crucial regulators of gene expression in tumorigenesis and are of great interest to researchers, but miRNA profiles are often inconsistent between studies. The aim of this study was to confirm candidate miRNA biomarkers for esophageal cancer from integrated‐miRNA expression profiling data and TCGA (The Cancer Genome Atlas) data in tissues. Here, we identify five significant miRNAs by a comprehensive analysis in esophageal cancer, and two of them (hsa‐miR‐100‐5p and hsa‐miR‐133b) show better prognoses with significant difference for both 3‐year and 5‐year survival. Additionally, they participate in esophageal cancer occurrence and development according to KEGG and Panther enrichment analyses. Therefore, these five miRNAs may serve as miRNA biomarkers in esophageal cancer. Analysis of differential expression for target genes of these miRNAs may also provide new therapeutic alternatives in esophageal cancer.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biomarkers, Tumor</subject><subject>Clinical Cancer Research</subject><subject>Computational Biology - methods</subject><subject>Databases, Genetic</subject><subject>Enrichment analysis</subject><subject>esophageal cancer</subject><subject>Esophageal Neoplasms - diagnosis</subject><subject>Esophageal Neoplasms - genetics</subject><subject>Esophageal Neoplasms - mortality</subject><subject>Female</subject><subject>Gene Expression Profiling</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Humans</subject><subject>Male</subject><subject>MicroRNAs - genetics</subject><subject>Middle Aged</subject><subject>Molecular Sequence Annotation</subject><subject>Original Research</subject><subject>Prognosis</subject><subject>Transcriptome</subject><subject>Young Adult</subject><issn>2045-7634</issn><issn>2045-7634</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>WIN</sourceid><sourceid>EIF</sourceid><recordid>eNpVUctOwzAQtBCIVqUHfgDlyCWtHTt2fEGqwlMqICE4W06ySY3yIk6KeuMT-Ea-hEQtVdnLrjSzM9IMQucEzwjG3jzWBZsR4skjNPYw813BKTs-uEdoau077kdgjwtyikZeILBgvhij6zA3pYl17qx13oFTpY4pW8ga3ULy8_VtTVbqtmvAKczL08L2qAO2qlc6g_4p1mUMzRk6SXVuYbrbE_R2e_Ma3rvL57uHcLF0a8qIdCnVic8F9YGkBLCUTGKZYOCR4DLWLEo0S9IIME0TISH1Eo5lyllMsBSSAJ2gq61u3UUFJDGUbaNzVTem0M1GVdqo_0hpViqr1sr3WRAI0Qtc7gSa6qMD26rC2BjyXJdQdVYR6eE-N8yDnnpx6LU3-YuuJ8y3hE-Tw2aPE6yGWtRQixpqUeHikQ0H_QXOTYCl</recordid><startdate>201708</startdate><enddate>201708</enddate><creator>Zhang, Heng‐Chao</creator><creator>Tang, Kai‐Fu</creator><general>John Wiley and Sons Inc</general><scope>24P</scope><scope>WIN</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-1672-1596</orcidid></search><sort><creationdate>201708</creationdate><title>Clinical value of integrated‐signature miRNAs in esophageal cancer</title><author>Zhang, Heng‐Chao ; Tang, Kai‐Fu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p3419-33ad56735e1f1e0994909d0e6b769ca4bda4dfbe03fd79ef2d609f64c109791e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biomarkers, Tumor</topic><topic>Clinical Cancer Research</topic><topic>Computational Biology - methods</topic><topic>Databases, Genetic</topic><topic>Enrichment analysis</topic><topic>esophageal cancer</topic><topic>Esophageal Neoplasms - diagnosis</topic><topic>Esophageal Neoplasms - genetics</topic><topic>Esophageal Neoplasms - mortality</topic><topic>Female</topic><topic>Gene Expression Profiling</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>Humans</topic><topic>Male</topic><topic>MicroRNAs - genetics</topic><topic>Middle Aged</topic><topic>Molecular Sequence Annotation</topic><topic>Original Research</topic><topic>Prognosis</topic><topic>Transcriptome</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Heng‐Chao</creatorcontrib><creatorcontrib>Tang, Kai‐Fu</creatorcontrib><collection>Wiley Online Library (Open Access Collection)</collection><collection>Wiley Online Library (Open Access Collection)</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cancer medicine (Malden, MA)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Heng‐Chao</au><au>Tang, Kai‐Fu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical value of integrated‐signature miRNAs in esophageal cancer</atitle><jtitle>Cancer medicine (Malden, MA)</jtitle><addtitle>Cancer Med</addtitle><date>2017-08</date><risdate>2017</risdate><volume>6</volume><issue>8</issue><spage>1893</spage><epage>1903</epage><pages>1893-1903</pages><issn>2045-7634</issn><eissn>2045-7634</eissn><abstract>MicroRNAs (miRNAs) are crucial regulators of gene expression in tumorigenesis and are of great interest to researchers, but miRNA profiles are often inconsistent between studies. The aim of this study was to confirm candidate miRNA biomarkers for esophageal cancer from integrated‐miRNA expression profiling data and TCGA (The Cancer Genome Atlas) data in tissues. Here, we identify five significant miRNAs by a comprehensive analysis in esophageal cancer, and two of them (hsa‐miR‐100‐5p and hsa‐miR‐133b) show better prognoses with significant difference for both 3‐year and 5‐year survival. Additionally, they participate in esophageal cancer occurrence and development according to KEGG and Panther enrichment analyses. Therefore, these five miRNAs may serve as miRNA biomarkers in esophageal cancer. Analysis of differential expression for target genes of these miRNAs may also provide new therapeutic alternatives in esophageal cancer.</abstract><cop>United States</cop><pub>John Wiley and Sons Inc</pub><pmid>28707457</pmid><doi>10.1002/cam4.1129</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-1672-1596</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2045-7634 |
| ispartof | Cancer medicine (Malden, MA), 2017-08, Vol.6 (8), p.1893-1903 |
| issn | 2045-7634 2045-7634 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5548877 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Access via Wiley Online Library; Wiley Online Library (Open Access Collection); PubMed Central |
| subjects | Adult Aged Aged, 80 and over Biomarkers, Tumor Clinical Cancer Research Computational Biology - methods Databases, Genetic Enrichment analysis esophageal cancer Esophageal Neoplasms - diagnosis Esophageal Neoplasms - genetics Esophageal Neoplasms - mortality Female Gene Expression Profiling Gene Expression Regulation, Neoplastic Humans Male MicroRNAs - genetics Middle Aged Molecular Sequence Annotation Original Research Prognosis Transcriptome Young Adult |
| title | Clinical value of integrated‐signature miRNAs in esophageal cancer |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-04T22%3A15%3A38IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Clinical%20value%20of%20integrated%E2%80%90signature%20miRNAs%20in%20esophageal%20cancer&rft.jtitle=Cancer%20medicine%20(Malden,%20MA)&rft.au=Zhang,%20Heng%E2%80%90Chao&rft.date=2017-08&rft.volume=6&rft.issue=8&rft.spage=1893&rft.epage=1903&rft.pages=1893-1903&rft.issn=2045-7634&rft.eissn=2045-7634&rft_id=info:doi/10.1002/cam4.1129&rft_dat=%3Cproquest_pubme%3E1920204068%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1920204068&rft_id=info:pmid/28707457&rfr_iscdi=true |