Sex-specific Associations of Maternal Birthweight with Offspring Birthweight in the Omega Study
Abstract Purpose We investigated nonlinear and offspring-sex specific associations of maternal birthweight (BW) with offspring BW among participants of the Omega study, a pregnancy cohort. Methods Maternal BW was modeled as a continuous variable, linear spline, and binary variable indicating low bir...
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| Veröffentlicht in: | Annals of epidemiology 2017-05, Vol.27 (5), p.308-314.e4 |
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| creator | Ncube, Collette N Gavin, Amelia R Williams, Michelle A Qiu, Chunfang Sorensen, Tanya K Enquobahrie, Daniel A |
| description | Abstract Purpose We investigated nonlinear and offspring-sex specific associations of maternal birthweight (BW) with offspring BW among participants of the Omega study, a pregnancy cohort. Methods Maternal BW was modeled as a continuous variable, linear spline, and binary variable indicating low birthweight (LBW) ( |
| doi_str_mv | 10.1016/j.annepidem.2017.04.006 |
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| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5548425</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>1_s2_0_S1047279716305701</els_id><sourcerecordid>1908432651</sourcerecordid><originalsourceid>FETCH-LOGICAL-c530t-e8074ffe53542a6dbd12428f3549a1b4af3c44ed4da194f41108af9cd8cccb3e3</originalsourceid><addsrcrecordid>eNqNkk1v1DAQhiMEoqXwFyBHLgn-jJ1LpaXiSyraw8LZ8jrjjZfEXmKnZf89jrasKCdOtjXvvDPjZ4riDUY1Rrh5t6-193BwHYw1QVjUiNUINU-KSywFrQiX_Gm-IyYqIlpxUbyIcY8QElKQ58UFkbzlgvLLQm3gVxUPYJx1plzFGIzTyQUfy2DLrzrB5PVQvndT6u_B7fpU3rvUl2tr42Fyfvco5HyZeijXI-x0uUlzd3xZPLN6iPDq4bwqvn_88O3mc3W7_vTlZnVbGU5RqkAiwawFTjkjuum2HSaMSJufrcZbpi01jEHHOo1bZhnGSGrbmk4aY7YU6FVxffI9zNsROgM-TXpQucVRT0cVtFOPI971ahfuFOdMMsKzwdsHgyn8nCEmNbpoYBi0hzBHhVskGSUNx1kqTlIzhRgnsOcyGKkFj9qrMx614FGIqYwnZ77-u8tz3h8eWbA6CSD_1Z2DSUXjwBvo3AQmqS64_yhy_Y-HGZx3Rg8_4AhxH-YFaZ5IRaKQ2ixbsiwJbijiAmH6G7lQvUI</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1908432651</pqid></control><display><type>article</type><title>Sex-specific Associations of Maternal Birthweight with Offspring Birthweight in the Omega Study</title><source>MEDLINE</source><source>ScienceDirect Journals (5 years ago - present)</source><creator>Ncube, Collette N ; Gavin, Amelia R ; Williams, Michelle A ; Qiu, Chunfang ; Sorensen, Tanya K ; Enquobahrie, Daniel A</creator><creatorcontrib>Ncube, Collette N ; Gavin, Amelia R ; Williams, Michelle A ; Qiu, Chunfang ; Sorensen, Tanya K ; Enquobahrie, Daniel A</creatorcontrib><description>Abstract Purpose We investigated nonlinear and offspring-sex specific associations of maternal birthweight (BW) with offspring BW among participants of the Omega study, a pregnancy cohort. Methods Maternal BW was modeled as a continuous variable, linear spline, and binary variable indicating low birthweight (LBW) (<2500 vs. ≥2500grams). Offspring BW was modeled as a continuous and binary variable in regression models. Non-linearity was assessed using likelihood ratio tests (LRT) in marginal linear spline models. Results For every 100gram increase of maternal BW, offspring BW increased by 22.29 (95%CI: 17.57, 27.02) or 23.41 (95%CI: 6.87, 39.96) grams among mothers with normal BW or born macrosomic, respectively, but not among LBW mothers (β=-8.61 grams; 95%CI: -22.88, 5.65) (LRT p-value=0.0005). For every 100gram increase in maternal BW, BW of male offspring increased 23.47 (95%CI: 16.75, 30.19) or 25.21 (95%CI: 4.35, 46.07) grams among mothers with normal BW or born macrosomic, respectively, while it decreased 31.39 grams (95%CI: -51.63, -11.15) among LBW mothers (LRT p-value<0.0001). Corresponding increases in BW of female offspring (16-22 grams) did not differ among mothers with LBW, normal BW or macrosomia (LRT p-value=0.9163). Conclusions Maternal and offspring BW associations are evident among normal BW and macrosomic mothers. These associations differ by offspring sex.</description><identifier>ISSN: 1047-2797</identifier><identifier>EISSN: 1873-2585</identifier><identifier>DOI: 10.1016/j.annepidem.2017.04.006</identifier><identifier>PMID: 28595735</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adult ; Birth Weight - physiology ; Birthweight ; Body Mass Index ; Cohort Studies ; Female ; Humans ; Infant ; Infant, Low Birth Weight ; Infant, Newborn ; Internal Medicine ; Interviews as Topic ; Low birthweight ; Male ; Mothers ; Pregnancy ; Pregnancy Outcome ; Sex ; Sex Factors ; Surveys and Questionnaires ; Washington ; Weight gain</subject><ispartof>Annals of epidemiology, 2017-05, Vol.27 (5), p.308-314.e4</ispartof><rights>2017 Elsevier Inc.</rights><rights>Copyright © 2017 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c530t-e8074ffe53542a6dbd12428f3549a1b4af3c44ed4da194f41108af9cd8cccb3e3</citedby><cites>FETCH-LOGICAL-c530t-e8074ffe53542a6dbd12428f3549a1b4af3c44ed4da194f41108af9cd8cccb3e3</cites><orcidid>0000-0002-0661-9926</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.annepidem.2017.04.006$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,780,784,885,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28595735$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ncube, Collette N</creatorcontrib><creatorcontrib>Gavin, Amelia R</creatorcontrib><creatorcontrib>Williams, Michelle A</creatorcontrib><creatorcontrib>Qiu, Chunfang</creatorcontrib><creatorcontrib>Sorensen, Tanya K</creatorcontrib><creatorcontrib>Enquobahrie, Daniel A</creatorcontrib><title>Sex-specific Associations of Maternal Birthweight with Offspring Birthweight in the Omega Study</title><title>Annals of epidemiology</title><addtitle>Ann Epidemiol</addtitle><description>Abstract Purpose We investigated nonlinear and offspring-sex specific associations of maternal birthweight (BW) with offspring BW among participants of the Omega study, a pregnancy cohort. Methods Maternal BW was modeled as a continuous variable, linear spline, and binary variable indicating low birthweight (LBW) (<2500 vs. ≥2500grams). Offspring BW was modeled as a continuous and binary variable in regression models. Non-linearity was assessed using likelihood ratio tests (LRT) in marginal linear spline models. Results For every 100gram increase of maternal BW, offspring BW increased by 22.29 (95%CI: 17.57, 27.02) or 23.41 (95%CI: 6.87, 39.96) grams among mothers with normal BW or born macrosomic, respectively, but not among LBW mothers (β=-8.61 grams; 95%CI: -22.88, 5.65) (LRT p-value=0.0005). For every 100gram increase in maternal BW, BW of male offspring increased 23.47 (95%CI: 16.75, 30.19) or 25.21 (95%CI: 4.35, 46.07) grams among mothers with normal BW or born macrosomic, respectively, while it decreased 31.39 grams (95%CI: -51.63, -11.15) among LBW mothers (LRT p-value<0.0001). Corresponding increases in BW of female offspring (16-22 grams) did not differ among mothers with LBW, normal BW or macrosomia (LRT p-value=0.9163). Conclusions Maternal and offspring BW associations are evident among normal BW and macrosomic mothers. These associations differ by offspring sex.</description><subject>Adult</subject><subject>Birth Weight - physiology</subject><subject>Birthweight</subject><subject>Body Mass Index</subject><subject>Cohort Studies</subject><subject>Female</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant, Low Birth Weight</subject><subject>Infant, Newborn</subject><subject>Internal Medicine</subject><subject>Interviews as Topic</subject><subject>Low birthweight</subject><subject>Male</subject><subject>Mothers</subject><subject>Pregnancy</subject><subject>Pregnancy Outcome</subject><subject>Sex</subject><subject>Sex Factors</subject><subject>Surveys and Questionnaires</subject><subject>Washington</subject><subject>Weight gain</subject><issn>1047-2797</issn><issn>1873-2585</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkk1v1DAQhiMEoqXwFyBHLgn-jJ1LpaXiSyraw8LZ8jrjjZfEXmKnZf89jrasKCdOtjXvvDPjZ4riDUY1Rrh5t6-193BwHYw1QVjUiNUINU-KSywFrQiX_Gm-IyYqIlpxUbyIcY8QElKQ58UFkbzlgvLLQm3gVxUPYJx1plzFGIzTyQUfy2DLrzrB5PVQvndT6u_B7fpU3rvUl2tr42Fyfvco5HyZeijXI-x0uUlzd3xZPLN6iPDq4bwqvn_88O3mc3W7_vTlZnVbGU5RqkAiwawFTjkjuum2HSaMSJufrcZbpi01jEHHOo1bZhnGSGrbmk4aY7YU6FVxffI9zNsROgM-TXpQucVRT0cVtFOPI971ahfuFOdMMsKzwdsHgyn8nCEmNbpoYBi0hzBHhVskGSUNx1kqTlIzhRgnsOcyGKkFj9qrMx614FGIqYwnZ77-u8tz3h8eWbA6CSD_1Z2DSUXjwBvo3AQmqS64_yhy_Y-HGZx3Rg8_4AhxH-YFaZ5IRaKQ2ixbsiwJbijiAmH6G7lQvUI</recordid><startdate>20170501</startdate><enddate>20170501</enddate><creator>Ncube, Collette N</creator><creator>Gavin, Amelia R</creator><creator>Williams, Michelle A</creator><creator>Qiu, Chunfang</creator><creator>Sorensen, Tanya K</creator><creator>Enquobahrie, Daniel A</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-0661-9926</orcidid></search><sort><creationdate>20170501</creationdate><title>Sex-specific Associations of Maternal Birthweight with Offspring Birthweight in the Omega Study</title><author>Ncube, Collette N ; Gavin, Amelia R ; Williams, Michelle A ; Qiu, Chunfang ; Sorensen, Tanya K ; Enquobahrie, Daniel A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c530t-e8074ffe53542a6dbd12428f3549a1b4af3c44ed4da194f41108af9cd8cccb3e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adult</topic><topic>Birth Weight - physiology</topic><topic>Birthweight</topic><topic>Body Mass Index</topic><topic>Cohort Studies</topic><topic>Female</topic><topic>Humans</topic><topic>Infant</topic><topic>Infant, Low Birth Weight</topic><topic>Infant, Newborn</topic><topic>Internal Medicine</topic><topic>Interviews as Topic</topic><topic>Low birthweight</topic><topic>Male</topic><topic>Mothers</topic><topic>Pregnancy</topic><topic>Pregnancy Outcome</topic><topic>Sex</topic><topic>Sex Factors</topic><topic>Surveys and Questionnaires</topic><topic>Washington</topic><topic>Weight gain</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ncube, Collette N</creatorcontrib><creatorcontrib>Gavin, Amelia R</creatorcontrib><creatorcontrib>Williams, Michelle A</creatorcontrib><creatorcontrib>Qiu, Chunfang</creatorcontrib><creatorcontrib>Sorensen, Tanya K</creatorcontrib><creatorcontrib>Enquobahrie, Daniel A</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Annals of epidemiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ncube, Collette N</au><au>Gavin, Amelia R</au><au>Williams, Michelle A</au><au>Qiu, Chunfang</au><au>Sorensen, Tanya K</au><au>Enquobahrie, Daniel A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sex-specific Associations of Maternal Birthweight with Offspring Birthweight in the Omega Study</atitle><jtitle>Annals of epidemiology</jtitle><addtitle>Ann Epidemiol</addtitle><date>2017-05-01</date><risdate>2017</risdate><volume>27</volume><issue>5</issue><spage>308</spage><epage>314.e4</epage><pages>308-314.e4</pages><issn>1047-2797</issn><eissn>1873-2585</eissn><abstract>Abstract Purpose We investigated nonlinear and offspring-sex specific associations of maternal birthweight (BW) with offspring BW among participants of the Omega study, a pregnancy cohort. Methods Maternal BW was modeled as a continuous variable, linear spline, and binary variable indicating low birthweight (LBW) (<2500 vs. ≥2500grams). Offspring BW was modeled as a continuous and binary variable in regression models. Non-linearity was assessed using likelihood ratio tests (LRT) in marginal linear spline models. Results For every 100gram increase of maternal BW, offspring BW increased by 22.29 (95%CI: 17.57, 27.02) or 23.41 (95%CI: 6.87, 39.96) grams among mothers with normal BW or born macrosomic, respectively, but not among LBW mothers (β=-8.61 grams; 95%CI: -22.88, 5.65) (LRT p-value=0.0005). For every 100gram increase in maternal BW, BW of male offspring increased 23.47 (95%CI: 16.75, 30.19) or 25.21 (95%CI: 4.35, 46.07) grams among mothers with normal BW or born macrosomic, respectively, while it decreased 31.39 grams (95%CI: -51.63, -11.15) among LBW mothers (LRT p-value<0.0001). Corresponding increases in BW of female offspring (16-22 grams) did not differ among mothers with LBW, normal BW or macrosomia (LRT p-value=0.9163). Conclusions Maternal and offspring BW associations are evident among normal BW and macrosomic mothers. These associations differ by offspring sex.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>28595735</pmid><doi>10.1016/j.annepidem.2017.04.006</doi><orcidid>https://orcid.org/0000-0002-0661-9926</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Birth Weight - physiology Birthweight Body Mass Index Cohort Studies Female Humans Infant Infant, Low Birth Weight Infant, Newborn Internal Medicine Interviews as Topic Low birthweight Male Mothers Pregnancy Pregnancy Outcome Sex Sex Factors Surveys and Questionnaires Washington Weight gain |
| title | Sex-specific Associations of Maternal Birthweight with Offspring Birthweight in the Omega Study |
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