Lipo-prostaglandin E1 modifies cognitive impairment in rats with vascular cognitive impairment by promoting angiogenesis via the VEGF/VEGFR pathway
The pathological mechanism of vascular cognitive impairment (VCI) involves ischemic lesions in the hippocampus. Prostaglandin E1 (PGE1) serves roles in the promotion of vascular endothelial growth factor (VEGF) expression, angiogenesis and enhances blood flow to ischemic regions. However, the effect...
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| Veröffentlicht in: | Molecular medicine reports 2017-09, Vol.16 (3), p.3117-3124 |
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| creator | Liu, Bohui Zhang, Suping Xiong, Xifeng Ling, Li He, Rui Wang, Muzhen Deng, Wanqing Liu, Zhihe Li, Yi |
| description | The pathological mechanism of vascular cognitive impairment (VCI) involves ischemic lesions in the hippocampus. Prostaglandin E1 (PGE1) serves roles in the promotion of vascular endothelial growth factor (VEGF) expression, angiogenesis and enhances blood flow to ischemic regions. However, the effect of PGE1 on cognitive function in VCI rats and the underlying mechanism are unknown. In the current study, learning and memory function in VCI rats treated by lipo-PGE1 injection was assessed through Morris Water Maze test. Furthermore, the histological alterations, blood vessel numbers in the hippocampal CA1 region and relative VEGF protein and mRNA expression were researched. The results confirmed that VCI rats treated with lipo-PGE1 presented improved cognitive function, less neuronal cell loss, a greater number of blood vessels in the hippocampal region and higher VEGF protein and mRNA expression. However, the role of lipo-PGE1 in VCI rats can be inhibited by SU5416 (a specific VEGFR2 antagonist). The results indicated that lipo-PGE1 may alleviate cognitive deficits in VCI rats. The underlying mechanism may be associated with angiogenesis promoted by lipo-PGE1, which may involve the VEGF/VEGFR pathway. These findings may have therapeutic implications for cognitive impairment induced by hypoperfusion or chronic ischemic lesions. |
| doi_str_mv | 10.3892/mmr.2017.6984 |
| format | Article |
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Prostaglandin E1 (PGE1) serves roles in the promotion of vascular endothelial growth factor (VEGF) expression, angiogenesis and enhances blood flow to ischemic regions. However, the effect of PGE1 on cognitive function in VCI rats and the underlying mechanism are unknown. In the current study, learning and memory function in VCI rats treated by lipo-PGE1 injection was assessed through Morris Water Maze test. Furthermore, the histological alterations, blood vessel numbers in the hippocampal CA1 region and relative VEGF protein and mRNA expression were researched. The results confirmed that VCI rats treated with lipo-PGE1 presented improved cognitive function, less neuronal cell loss, a greater number of blood vessels in the hippocampal region and higher VEGF protein and mRNA expression. However, the role of lipo-PGE1 in VCI rats can be inhibited by SU5416 (a specific VEGFR2 antagonist). The results indicated that lipo-PGE1 may alleviate cognitive deficits in VCI rats. The underlying mechanism may be associated with angiogenesis promoted by lipo-PGE1, which may involve the VEGF/VEGFR pathway. These findings may have therapeutic implications for cognitive impairment induced by hypoperfusion or chronic ischemic lesions.</description><identifier>ISSN: 1791-2997</identifier><identifier>EISSN: 1791-3004</identifier><identifier>DOI: 10.3892/mmr.2017.6984</identifier><identifier>PMID: 28713958</identifier><language>eng</language><publisher>Greece: D.A. Spandidos</publisher><subject>Alprostadil - pharmacology ; Alprostadil - therapeutic use ; Angiogenesis ; Animal cognition ; Animals ; Blood flow ; Blood vessels ; Brain-derived neurotrophic factor ; CA1 Region, Hippocampal - drug effects ; CA1 Region, Hippocampal - pathology ; CA1 Region, Hippocampal - physiopathology ; Cell growth ; Cognitive ability ; Cognitive Dysfunction - drug therapy ; Cognitive Dysfunction - genetics ; Cognitive Dysfunction - physiopathology ; cognitive impairment ; Dementia ; Disease ; Endothelium ; Gene expression ; Gene Expression Regulation - drug effects ; Hippocampus ; Ischemia ; Kinases ; Laboratory animals ; Learning ; lipo-PGE1 ; Male ; Memory ; Neovascularization, Physiologic - drug effects ; Neurogenesis ; Neurons ; Oxidative stress ; Perfusion ; Prostaglandin E1 ; Rats, Sprague-Dawley ; RNA, Messenger - genetics ; RNA, Messenger - metabolism ; Rodents ; Signal transduction ; Spatial Memory - drug effects ; Studies ; Surgery ; Vascular endothelial growth factor ; Vascular Endothelial Growth Factor A - genetics ; Vascular Endothelial Growth Factor A - metabolism ; vascular endothelial growth factor receptor antagonist ; Vascular Endothelial Growth Factor Receptor-2 - metabolism ; Vascular endothelial growth factor receptors ; Veins & arteries</subject><ispartof>Molecular medicine reports, 2017-09, Vol.16 (3), p.3117-3124</ispartof><rights>Copyright: © Liu et al.</rights><rights>Copyright Spandidos Publications UK Ltd. 2017</rights><rights>Copyright: © Liu et al. 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2924-ee131c93c7139569877402cb543b2acad7a9dfc4d3c0b2c7a0c08c91c51621293</citedby><cites>FETCH-LOGICAL-c2924-ee131c93c7139569877402cb543b2acad7a9dfc4d3c0b2c7a0c08c91c51621293</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,5571,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28713958$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liu, Bohui</creatorcontrib><creatorcontrib>Zhang, Suping</creatorcontrib><creatorcontrib>Xiong, Xifeng</creatorcontrib><creatorcontrib>Ling, Li</creatorcontrib><creatorcontrib>He, Rui</creatorcontrib><creatorcontrib>Wang, Muzhen</creatorcontrib><creatorcontrib>Deng, Wanqing</creatorcontrib><creatorcontrib>Liu, Zhihe</creatorcontrib><creatorcontrib>Li, Yi</creatorcontrib><title>Lipo-prostaglandin E1 modifies cognitive impairment in rats with vascular cognitive impairment by promoting angiogenesis via the VEGF/VEGFR pathway</title><title>Molecular medicine reports</title><addtitle>Mol Med Rep</addtitle><description>The pathological mechanism of vascular cognitive impairment (VCI) involves ischemic lesions in the hippocampus. Prostaglandin E1 (PGE1) serves roles in the promotion of vascular endothelial growth factor (VEGF) expression, angiogenesis and enhances blood flow to ischemic regions. However, the effect of PGE1 on cognitive function in VCI rats and the underlying mechanism are unknown. In the current study, learning and memory function in VCI rats treated by lipo-PGE1 injection was assessed through Morris Water Maze test. Furthermore, the histological alterations, blood vessel numbers in the hippocampal CA1 region and relative VEGF protein and mRNA expression were researched. The results confirmed that VCI rats treated with lipo-PGE1 presented improved cognitive function, less neuronal cell loss, a greater number of blood vessels in the hippocampal region and higher VEGF protein and mRNA expression. However, the role of lipo-PGE1 in VCI rats can be inhibited by SU5416 (a specific VEGFR2 antagonist). The results indicated that lipo-PGE1 may alleviate cognitive deficits in VCI rats. The underlying mechanism may be associated with angiogenesis promoted by lipo-PGE1, which may involve the VEGF/VEGFR pathway. These findings may have therapeutic implications for cognitive impairment induced by hypoperfusion or chronic ischemic lesions.</description><subject>Alprostadil - pharmacology</subject><subject>Alprostadil - therapeutic use</subject><subject>Angiogenesis</subject><subject>Animal cognition</subject><subject>Animals</subject><subject>Blood flow</subject><subject>Blood vessels</subject><subject>Brain-derived neurotrophic factor</subject><subject>CA1 Region, Hippocampal - drug effects</subject><subject>CA1 Region, Hippocampal - pathology</subject><subject>CA1 Region, Hippocampal - physiopathology</subject><subject>Cell growth</subject><subject>Cognitive ability</subject><subject>Cognitive Dysfunction - drug therapy</subject><subject>Cognitive Dysfunction - genetics</subject><subject>Cognitive Dysfunction - physiopathology</subject><subject>cognitive impairment</subject><subject>Dementia</subject><subject>Disease</subject><subject>Endothelium</subject><subject>Gene expression</subject><subject>Gene Expression Regulation - drug effects</subject><subject>Hippocampus</subject><subject>Ischemia</subject><subject>Kinases</subject><subject>Laboratory animals</subject><subject>Learning</subject><subject>lipo-PGE1</subject><subject>Male</subject><subject>Memory</subject><subject>Neovascularization, Physiologic - drug effects</subject><subject>Neurogenesis</subject><subject>Neurons</subject><subject>Oxidative stress</subject><subject>Perfusion</subject><subject>Prostaglandin E1</subject><subject>Rats, Sprague-Dawley</subject><subject>RNA, Messenger - genetics</subject><subject>RNA, Messenger - metabolism</subject><subject>Rodents</subject><subject>Signal transduction</subject><subject>Spatial Memory - drug effects</subject><subject>Studies</subject><subject>Surgery</subject><subject>Vascular endothelial growth factor</subject><subject>Vascular Endothelial Growth Factor A - genetics</subject><subject>Vascular Endothelial Growth Factor A - metabolism</subject><subject>vascular endothelial growth factor receptor antagonist</subject><subject>Vascular Endothelial Growth Factor Receptor-2 - metabolism</subject><subject>Vascular endothelial growth factor receptors</subject><subject>Veins & arteries</subject><issn>1791-2997</issn><issn>1791-3004</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNptkUGL1DAYhoMo7rp69CoBD3rJbL6kbZqLIMvsKgwIol5DmmY6WdqmJuks8zv8w6bOOKh4SQJ5ePne70HoJdAVryW7HoawYhTEqpJ18QhdgpBAOKXF49ObSSku0LMY7ymtSlbKp-iC1QK4LOtL9GPjJk-m4GPSXa_H1o14DXjwrds6G7Hx3eiS21vshkm7MNgx4cwEnSJ-cGmH9zqaudfh_2hzwDl88MmNHdZj53xnRxtdxHuncdpZ_G19d3u9HJ_xpNPuQR-eoydb3Uf74nRfoa-36y83H8jm093Hm_cbYphkBbEWOBjJza8uub4QBWWmKQveMG10K7Rst6ZouaENM0JTQ2sjwZRQMWCSX6F3x9xpbgbbmjxv0L2aght0OCivnfr7Z3Q71fm9KsuipgxywNtTQPDfZxuTGlw0ts97tH6OCmQ2k9dc0Yy-_ge993MYc71MFQxKoGKhyJEyWUgMdnseBqhadKusWy261aI786_-bHCmf_vNwJsjEKfFbevjmclJBCpCOeEAgv8EHSq2EA</recordid><startdate>201709</startdate><enddate>201709</enddate><creator>Liu, Bohui</creator><creator>Zhang, Suping</creator><creator>Xiong, Xifeng</creator><creator>Ling, Li</creator><creator>He, Rui</creator><creator>Wang, Muzhen</creator><creator>Deng, Wanqing</creator><creator>Liu, Zhihe</creator><creator>Li, Yi</creator><general>D.A. Spandidos</general><general>Spandidos Publications UK Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201709</creationdate><title>Lipo-prostaglandin E1 modifies cognitive impairment in rats with vascular cognitive impairment by promoting angiogenesis via the VEGF/VEGFR pathway</title><author>Liu, Bohui ; Zhang, Suping ; Xiong, Xifeng ; Ling, Li ; He, Rui ; Wang, Muzhen ; Deng, Wanqing ; Liu, Zhihe ; Li, Yi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2924-ee131c93c7139569877402cb543b2acad7a9dfc4d3c0b2c7a0c08c91c51621293</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Alprostadil - pharmacology</topic><topic>Alprostadil - therapeutic use</topic><topic>Angiogenesis</topic><topic>Animal cognition</topic><topic>Animals</topic><topic>Blood flow</topic><topic>Blood vessels</topic><topic>Brain-derived neurotrophic factor</topic><topic>CA1 Region, Hippocampal - drug effects</topic><topic>CA1 Region, Hippocampal - pathology</topic><topic>CA1 Region, Hippocampal - physiopathology</topic><topic>Cell growth</topic><topic>Cognitive ability</topic><topic>Cognitive Dysfunction - drug therapy</topic><topic>Cognitive Dysfunction - genetics</topic><topic>Cognitive Dysfunction - physiopathology</topic><topic>cognitive impairment</topic><topic>Dementia</topic><topic>Disease</topic><topic>Endothelium</topic><topic>Gene expression</topic><topic>Gene Expression Regulation - drug effects</topic><topic>Hippocampus</topic><topic>Ischemia</topic><topic>Kinases</topic><topic>Laboratory animals</topic><topic>Learning</topic><topic>lipo-PGE1</topic><topic>Male</topic><topic>Memory</topic><topic>Neovascularization, Physiologic - drug effects</topic><topic>Neurogenesis</topic><topic>Neurons</topic><topic>Oxidative stress</topic><topic>Perfusion</topic><topic>Prostaglandin E1</topic><topic>Rats, Sprague-Dawley</topic><topic>RNA, Messenger - genetics</topic><topic>RNA, Messenger - metabolism</topic><topic>Rodents</topic><topic>Signal transduction</topic><topic>Spatial Memory - drug effects</topic><topic>Studies</topic><topic>Surgery</topic><topic>Vascular endothelial growth factor</topic><topic>Vascular Endothelial Growth Factor A - genetics</topic><topic>Vascular Endothelial Growth Factor A - metabolism</topic><topic>vascular endothelial growth factor receptor antagonist</topic><topic>Vascular Endothelial Growth Factor Receptor-2 - metabolism</topic><topic>Vascular endothelial growth factor receptors</topic><topic>Veins & arteries</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liu, Bohui</creatorcontrib><creatorcontrib>Zhang, Suping</creatorcontrib><creatorcontrib>Xiong, Xifeng</creatorcontrib><creatorcontrib>Ling, Li</creatorcontrib><creatorcontrib>He, Rui</creatorcontrib><creatorcontrib>Wang, Muzhen</creatorcontrib><creatorcontrib>Deng, Wanqing</creatorcontrib><creatorcontrib>Liu, Zhihe</creatorcontrib><creatorcontrib>Li, Yi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Molecular medicine reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, Bohui</au><au>Zhang, Suping</au><au>Xiong, Xifeng</au><au>Ling, Li</au><au>He, Rui</au><au>Wang, Muzhen</au><au>Deng, Wanqing</au><au>Liu, Zhihe</au><au>Li, Yi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lipo-prostaglandin E1 modifies cognitive impairment in rats with vascular cognitive impairment by promoting angiogenesis via the VEGF/VEGFR pathway</atitle><jtitle>Molecular medicine reports</jtitle><addtitle>Mol Med Rep</addtitle><date>2017-09</date><risdate>2017</risdate><volume>16</volume><issue>3</issue><spage>3117</spage><epage>3124</epage><pages>3117-3124</pages><issn>1791-2997</issn><eissn>1791-3004</eissn><abstract>The pathological mechanism of vascular cognitive impairment (VCI) involves ischemic lesions in the hippocampus. Prostaglandin E1 (PGE1) serves roles in the promotion of vascular endothelial growth factor (VEGF) expression, angiogenesis and enhances blood flow to ischemic regions. However, the effect of PGE1 on cognitive function in VCI rats and the underlying mechanism are unknown. In the current study, learning and memory function in VCI rats treated by lipo-PGE1 injection was assessed through Morris Water Maze test. Furthermore, the histological alterations, blood vessel numbers in the hippocampal CA1 region and relative VEGF protein and mRNA expression were researched. The results confirmed that VCI rats treated with lipo-PGE1 presented improved cognitive function, less neuronal cell loss, a greater number of blood vessels in the hippocampal region and higher VEGF protein and mRNA expression. However, the role of lipo-PGE1 in VCI rats can be inhibited by SU5416 (a specific VEGFR2 antagonist). The results indicated that lipo-PGE1 may alleviate cognitive deficits in VCI rats. The underlying mechanism may be associated with angiogenesis promoted by lipo-PGE1, which may involve the VEGF/VEGFR pathway. These findings may have therapeutic implications for cognitive impairment induced by hypoperfusion or chronic ischemic lesions.</abstract><cop>Greece</cop><pub>D.A. Spandidos</pub><pmid>28713958</pmid><doi>10.3892/mmr.2017.6984</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| source | Spandidos Publications Journals; MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Alprostadil - pharmacology Alprostadil - therapeutic use Angiogenesis Animal cognition Animals Blood flow Blood vessels Brain-derived neurotrophic factor CA1 Region, Hippocampal - drug effects CA1 Region, Hippocampal - pathology CA1 Region, Hippocampal - physiopathology Cell growth Cognitive ability Cognitive Dysfunction - drug therapy Cognitive Dysfunction - genetics Cognitive Dysfunction - physiopathology cognitive impairment Dementia Disease Endothelium Gene expression Gene Expression Regulation - drug effects Hippocampus Ischemia Kinases Laboratory animals Learning lipo-PGE1 Male Memory Neovascularization, Physiologic - drug effects Neurogenesis Neurons Oxidative stress Perfusion Prostaglandin E1 Rats, Sprague-Dawley RNA, Messenger - genetics RNA, Messenger - metabolism Rodents Signal transduction Spatial Memory - drug effects Studies Surgery Vascular endothelial growth factor Vascular Endothelial Growth Factor A - genetics Vascular Endothelial Growth Factor A - metabolism vascular endothelial growth factor receptor antagonist Vascular Endothelial Growth Factor Receptor-2 - metabolism Vascular endothelial growth factor receptors Veins & arteries |
| title | Lipo-prostaglandin E1 modifies cognitive impairment in rats with vascular cognitive impairment by promoting angiogenesis via the VEGF/VEGFR pathway |
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