Dormant origins as a built-in safeguard in eukaryotic DNA replication against genome instability and disease development

DNA replication is a prerequisite for cell proliferation, yet it can be increasingly challenging for a eukaryotic cell to faithfully duplicate its genome as its size and complexity expands. Dormant origins now emerge as a key component for cells to successfully accomplish such a demanding but essent...

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Veröffentlicht in:	DNA repair 2017-08, Vol.56, p.166-173
Hauptverfasser:	Shima, Naoko, Pederson, Kayla D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cancer DNA - metabolism DNA Repair DNA Replication Dormant replication origins Eukaryota - genetics Eukaryota - metabolism Genomic Instability Humans MCM2-7 Neoplasms - genetics Neoplasms - metabolism Rare human genetic diseases Replication Origin Replication stress Replication-associated genome instability Stem cells Stem Cells - metabolism
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