Substance P activates Mas-related G protein–coupled receptors to induce itch
Background Substance P (SP) is linked to itch and inflammation through activation of receptors on mast cells and sensory neurons. There is increasing evidence that SP functions through Mas-related G protein–coupled receptors (Mrgprs) in addition to its conventional receptor, neurokinin-1. Objective...
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| Veröffentlicht in: | Journal of allergy and clinical immunology 2017-08, Vol.140 (2), p.447-453.e3 |
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| container_end_page | 453.e3 |
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| container_issue | 2 |
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| container_title | Journal of allergy and clinical immunology |
| container_volume | 140 |
| creator | Azimi, Ehsan, MD Reddy, Vemuri B., PhD Pereira, Paula Juliana Seadi, PhD Talbot, Sebastien, PhD Woolf, Clifford J., MD, PhD Lerner, Ethan A., MD, PhD |
| description | Background Substance P (SP) is linked to itch and inflammation through activation of receptors on mast cells and sensory neurons. There is increasing evidence that SP functions through Mas-related G protein–coupled receptors (Mrgprs) in addition to its conventional receptor, neurokinin-1. Objective Because Mrgprs mediate some aspects of inflammation that had been considered mediated by neurokinin-1 receptor (NK-1R), we sought to determine whether itch induced by SP can also be mediated by Mrgprs. Methods Genetic and pharmacologic approaches were used to evaluate the contribution of Mrgprs to SP-induced scratching behavior and activation of cultured dorsal root ganglion neurons from mice. Results SP-induced scratching behavior and activation of cultured dorsal root ganglion neurons was dependent on Mrgprs rather than NK-1R. Conclusion We deduce that SP activates MrgprA1 on sensory neurons rather than NK-1R to induce itch. |
| doi_str_mv | 10.1016/j.jaci.2016.12.980 |
| format | Article |
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There is increasing evidence that SP functions through Mas-related G protein–coupled receptors (Mrgprs) in addition to its conventional receptor, neurokinin-1. Objective Because Mrgprs mediate some aspects of inflammation that had been considered mediated by neurokinin-1 receptor (NK-1R), we sought to determine whether itch induced by SP can also be mediated by Mrgprs. Methods Genetic and pharmacologic approaches were used to evaluate the contribution of Mrgprs to SP-induced scratching behavior and activation of cultured dorsal root ganglion neurons from mice. Results SP-induced scratching behavior and activation of cultured dorsal root ganglion neurons was dependent on Mrgprs rather than NK-1R. Conclusion We deduce that SP activates MrgprA1 on sensory neurons rather than NK-1R to induce itch.</description><identifier>ISSN: 0091-6749</identifier><identifier>EISSN: 1097-6825</identifier><identifier>DOI: 10.1016/j.jaci.2016.12.980</identifier><identifier>PMID: 28219706</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Activation ; Activation analysis ; Adolescent ; Adult ; Aged ; Allergy and Immunology ; Animals ; calcium imaging ; Capsaicin - pharmacology ; Cells, Cultured ; Dorsal root ganglia ; dorsal root ganglion neurons ; Female ; G protein-coupled receptors ; Ganglia, Spinal - cytology ; Humans ; Immunology ; Inflammation ; knockout mice ; Male ; Mas-related G protein–coupled receptors ; Mast cells ; Mice ; Mice, Transgenic ; Middle Aged ; Neurokinin ; Neurokinin NK1 receptors ; Neurons ; Peptides ; Pruritus - chemically induced ; Pruritus - genetics ; receptor antagonist ; Receptors, G-Protein-Coupled - genetics ; Receptors, Neurokinin-1 - genetics ; Scratching ; Scratching behavior ; Sensory neurons ; Sensory perception ; Sensory Receptor Cells - drug effects ; Substance P ; Young Adult</subject><ispartof>Journal of allergy and clinical immunology, 2017-08, Vol.140 (2), p.447-453.e3</ispartof><rights>American Academy of Allergy, Asthma & Immunology</rights><rights>2017 American Academy of Allergy, Asthma & Immunology</rights><rights>Copyright © 2017 American Academy of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.</rights><rights>Copyright Elsevier Science Ltd. Aug 1, 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c604t-c44a1d247e7f755c9d47aff9e5681d093359e664e3370808d79ff45777d37bc53</citedby><cites>FETCH-LOGICAL-c604t-c44a1d247e7f755c9d47aff9e5681d093359e664e3370808d79ff45777d37bc53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0091674917302300$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28219706$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Azimi, Ehsan, MD</creatorcontrib><creatorcontrib>Reddy, Vemuri B., PhD</creatorcontrib><creatorcontrib>Pereira, Paula Juliana Seadi, PhD</creatorcontrib><creatorcontrib>Talbot, Sebastien, PhD</creatorcontrib><creatorcontrib>Woolf, Clifford J., MD, PhD</creatorcontrib><creatorcontrib>Lerner, Ethan A., MD, PhD</creatorcontrib><title>Substance P activates Mas-related G protein–coupled receptors to induce itch</title><title>Journal of allergy and clinical immunology</title><addtitle>J Allergy Clin Immunol</addtitle><description>Background Substance P (SP) is linked to itch and inflammation through activation of receptors on mast cells and sensory neurons. There is increasing evidence that SP functions through Mas-related G protein–coupled receptors (Mrgprs) in addition to its conventional receptor, neurokinin-1. Objective Because Mrgprs mediate some aspects of inflammation that had been considered mediated by neurokinin-1 receptor (NK-1R), we sought to determine whether itch induced by SP can also be mediated by Mrgprs. Methods Genetic and pharmacologic approaches were used to evaluate the contribution of Mrgprs to SP-induced scratching behavior and activation of cultured dorsal root ganglion neurons from mice. Results SP-induced scratching behavior and activation of cultured dorsal root ganglion neurons was dependent on Mrgprs rather than NK-1R. Conclusion We deduce that SP activates MrgprA1 on sensory neurons rather than NK-1R to induce itch.</description><subject>Activation</subject><subject>Activation analysis</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Allergy and Immunology</subject><subject>Animals</subject><subject>calcium imaging</subject><subject>Capsaicin - pharmacology</subject><subject>Cells, Cultured</subject><subject>Dorsal root ganglia</subject><subject>dorsal root ganglion neurons</subject><subject>Female</subject><subject>G protein-coupled receptors</subject><subject>Ganglia, Spinal - cytology</subject><subject>Humans</subject><subject>Immunology</subject><subject>Inflammation</subject><subject>knockout mice</subject><subject>Male</subject><subject>Mas-related G protein–coupled receptors</subject><subject>Mast cells</subject><subject>Mice</subject><subject>Mice, Transgenic</subject><subject>Middle Aged</subject><subject>Neurokinin</subject><subject>Neurokinin NK1 receptors</subject><subject>Neurons</subject><subject>Peptides</subject><subject>Pruritus - chemically induced</subject><subject>Pruritus - genetics</subject><subject>receptor antagonist</subject><subject>Receptors, G-Protein-Coupled - genetics</subject><subject>Receptors, Neurokinin-1 - genetics</subject><subject>Scratching</subject><subject>Scratching behavior</subject><subject>Sensory neurons</subject><subject>Sensory perception</subject><subject>Sensory Receptor Cells - drug effects</subject><subject>Substance P</subject><subject>Young Adult</subject><issn>0091-6749</issn><issn>1097-6825</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9UsFuFSEUJUZjn9UfcGEmcT0jMDBAYpqYRqtJa02qa8KDO5ZxOozAvKQ7_8E_9Etk8tqqXbjiAuccDvdchJ4T3BBMuldDMxjrG1rqhtBGSfwAbQhWou4k5Q_RBmNF6k4wdYCepDTgsm-leowOqKRECdxt0MeLZZuymSxUnypjs9-ZDKk6M6mOMJbaVSfVHEMGP_368dOGZR7LWQQLcw4xVTlUfnJL4ftsL5-iR70ZEzy7WQ_Rl3dvPx-_r0_PTz4cvzmtbYdZri1jhjjKBIhecG6VY8L0vQLeSeKKy5Yr6DoGbSuwxNIJ1feMCyFcK7aWt4foaK87L9srcBamHM2o5-ivTLzWwXj9783kL_XXsNOcs04xXARe3gjE8H2BlPUQljgVz5ooyhUmUsqConuUjSGlCP3dCwTrNQM96DUDvWagCdUlg0J68be3O8pt0wvg9R4ApUM7D1En66FE4Hzpa9Yu-P_rH92j29FP3prxG1xD-vMPnajG-mKdgnUIiGgxbTFufwMrWK4k</recordid><startdate>20170801</startdate><enddate>20170801</enddate><creator>Azimi, Ehsan, MD</creator><creator>Reddy, Vemuri B., PhD</creator><creator>Pereira, Paula Juliana Seadi, PhD</creator><creator>Talbot, Sebastien, PhD</creator><creator>Woolf, Clifford J., MD, PhD</creator><creator>Lerner, Ethan A., MD, PhD</creator><general>Elsevier Inc</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SS</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>5PM</scope></search><sort><creationdate>20170801</creationdate><title>Substance P activates Mas-related G protein–coupled receptors to induce itch</title><author>Azimi, Ehsan, MD ; Reddy, Vemuri B., PhD ; Pereira, Paula Juliana Seadi, PhD ; Talbot, Sebastien, PhD ; Woolf, Clifford J., MD, PhD ; Lerner, Ethan A., MD, PhD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c604t-c44a1d247e7f755c9d47aff9e5681d093359e664e3370808d79ff45777d37bc53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Activation</topic><topic>Activation analysis</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Allergy and Immunology</topic><topic>Animals</topic><topic>calcium imaging</topic><topic>Capsaicin - pharmacology</topic><topic>Cells, Cultured</topic><topic>Dorsal root ganglia</topic><topic>dorsal root ganglion neurons</topic><topic>Female</topic><topic>G protein-coupled receptors</topic><topic>Ganglia, Spinal - cytology</topic><topic>Humans</topic><topic>Immunology</topic><topic>Inflammation</topic><topic>knockout mice</topic><topic>Male</topic><topic>Mas-related G protein–coupled receptors</topic><topic>Mast cells</topic><topic>Mice</topic><topic>Mice, Transgenic</topic><topic>Middle Aged</topic><topic>Neurokinin</topic><topic>Neurokinin NK1 receptors</topic><topic>Neurons</topic><topic>Peptides</topic><topic>Pruritus - chemically induced</topic><topic>Pruritus - genetics</topic><topic>receptor antagonist</topic><topic>Receptors, G-Protein-Coupled - genetics</topic><topic>Receptors, Neurokinin-1 - genetics</topic><topic>Scratching</topic><topic>Scratching behavior</topic><topic>Sensory neurons</topic><topic>Sensory perception</topic><topic>Sensory Receptor Cells - drug effects</topic><topic>Substance P</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Azimi, Ehsan, MD</creatorcontrib><creatorcontrib>Reddy, Vemuri B., PhD</creatorcontrib><creatorcontrib>Pereira, Paula Juliana Seadi, PhD</creatorcontrib><creatorcontrib>Talbot, Sebastien, PhD</creatorcontrib><creatorcontrib>Woolf, Clifford J., MD, PhD</creatorcontrib><creatorcontrib>Lerner, Ethan A., MD, PhD</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of allergy and clinical immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Azimi, Ehsan, MD</au><au>Reddy, Vemuri B., PhD</au><au>Pereira, Paula Juliana Seadi, PhD</au><au>Talbot, Sebastien, PhD</au><au>Woolf, Clifford J., MD, PhD</au><au>Lerner, Ethan A., MD, PhD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Substance P activates Mas-related G protein–coupled receptors to induce itch</atitle><jtitle>Journal of allergy and clinical immunology</jtitle><addtitle>J Allergy Clin Immunol</addtitle><date>2017-08-01</date><risdate>2017</risdate><volume>140</volume><issue>2</issue><spage>447</spage><epage>453.e3</epage><pages>447-453.e3</pages><issn>0091-6749</issn><eissn>1097-6825</eissn><abstract>Background Substance P (SP) is linked to itch and inflammation through activation of receptors on mast cells and sensory neurons. There is increasing evidence that SP functions through Mas-related G protein–coupled receptors (Mrgprs) in addition to its conventional receptor, neurokinin-1. Objective Because Mrgprs mediate some aspects of inflammation that had been considered mediated by neurokinin-1 receptor (NK-1R), we sought to determine whether itch induced by SP can also be mediated by Mrgprs. Methods Genetic and pharmacologic approaches were used to evaluate the contribution of Mrgprs to SP-induced scratching behavior and activation of cultured dorsal root ganglion neurons from mice. Results SP-induced scratching behavior and activation of cultured dorsal root ganglion neurons was dependent on Mrgprs rather than NK-1R. Conclusion We deduce that SP activates MrgprA1 on sensory neurons rather than NK-1R to induce itch.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>28219706</pmid><doi>10.1016/j.jaci.2016.12.980</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Activation Activation analysis Adolescent Adult Aged Allergy and Immunology Animals calcium imaging Capsaicin - pharmacology Cells, Cultured Dorsal root ganglia dorsal root ganglion neurons Female G protein-coupled receptors Ganglia, Spinal - cytology Humans Immunology Inflammation knockout mice Male Mas-related G protein–coupled receptors Mast cells Mice Mice, Transgenic Middle Aged Neurokinin Neurokinin NK1 receptors Neurons Peptides Pruritus - chemically induced Pruritus - genetics receptor antagonist Receptors, G-Protein-Coupled - genetics Receptors, Neurokinin-1 - genetics Scratching Scratching behavior Sensory neurons Sensory perception Sensory Receptor Cells - drug effects Substance P Young Adult |
| title | Substance P activates Mas-related G protein–coupled receptors to induce itch |
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