Chimpanzee genomic diversity reveals ancient admixture with bonobos
Our closest living relatives, chimpanzees and bonobos, have a complex demographic history. We analyzed the high-coverage whole genomes of 75 wild-born chimpanzees and bonobos from 10 countries in Africa. We found that chimpanzee population substructure makes genetic information a good predictor of g...
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| Veröffentlicht in: | Science (American Association for the Advancement of Science) 2016-10, Vol.354 (6311), p.477-481 |
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| creator | de Manuel, Marc Kuhlwilm, Martin Frandsen, Peter Sousa, Vitor C. Desai, Tariq Prado-Martinez, Javier Hernandez-Rodriguez, Jessica Dupanloup, Isabelle Lao, Oscar Hallast, Pille Schmidt, Joshua M. Heredia-Genestar, José María Benazzo, Andrea Barbujani, Guido Peter, Benjamin M. Kuderna, Lukas F. K. Casals, Ferran Angedakin, Samuel Arandjelovic, Mimi Boesch, Christophe Kühl, Hjalmar Vigilant, Linda Langergraber, Kevin Novembre, John Gut, Marta Gut, Ivo Navarro, Arcadi Carlsen, Frauds Andres, Aida M. Siegismund, Hans. R. Scally, Aylwyn Excoffier, Laurent Tyler-Smith, Chris Castellano, Sergi Xue, Yali Hvilsom, Christina Marques-Bonet, Tomas |
| description | Our closest living relatives, chimpanzees and bonobos, have a complex demographic history. We analyzed the high-coverage whole genomes of 75 wild-born chimpanzees and bonobos from 10 countries in Africa. We found that chimpanzee population substructure makes genetic information a good predictor of geographic origin at country and regional scales. Multiple lines of evidence suggest that gene flow occurred from bonobos into the ancestors of central and eastern chimpanzees between 200,000 and 550,000 years ago, probably with subsequent spread into Nigeria-Cameroon chimpanzees. Together with another, possibly more recent contact (after 200,000 years ago), bonobos contributed less than 1% to the central chimpanzee genomes. Admixture thus appears to have been widespread during hominid evolution. |
| doi_str_mv | 10.1126/science.aag2602 |
| format | Article |
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K. ; Casals, Ferran ; Angedakin, Samuel ; Arandjelovic, Mimi ; Boesch, Christophe ; Kühl, Hjalmar ; Vigilant, Linda ; Langergraber, Kevin ; Novembre, John ; Gut, Marta ; Gut, Ivo ; Navarro, Arcadi ; Carlsen, Frauds ; Andres, Aida M. ; Siegismund, Hans. R. ; Scally, Aylwyn ; Excoffier, Laurent ; Tyler-Smith, Chris ; Castellano, Sergi ; Xue, Yali ; Hvilsom, Christina ; Marques-Bonet, Tomas</creator><creatorcontrib>de Manuel, Marc ; Kuhlwilm, Martin ; Frandsen, Peter ; Sousa, Vitor C. ; Desai, Tariq ; Prado-Martinez, Javier ; Hernandez-Rodriguez, Jessica ; Dupanloup, Isabelle ; Lao, Oscar ; Hallast, Pille ; Schmidt, Joshua M. ; Heredia-Genestar, José María ; Benazzo, Andrea ; Barbujani, Guido ; Peter, Benjamin M. ; Kuderna, Lukas F. K. ; Casals, Ferran ; Angedakin, Samuel ; Arandjelovic, Mimi ; Boesch, Christophe ; Kühl, Hjalmar ; Vigilant, Linda ; Langergraber, Kevin ; Novembre, John ; Gut, Marta ; Gut, Ivo ; Navarro, Arcadi ; Carlsen, Frauds ; Andres, Aida M. ; Siegismund, Hans. 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Admixture thus appears to have been widespread during hominid evolution.</description><identifier>ISSN: 0036-8075</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.aag2602</identifier><identifier>PMID: 27789843</identifier><identifier>CODEN: SCIEAS</identifier><language>eng</language><publisher>United States: American Association for the Advancement of Science</publisher><subject>Admixtures ; Animal populations ; Animals ; Bonobo ; Cameroon ; Chimpanzees ; Contact ; Demographics ; Evolució molecular ; Evolution ; Evolution, Molecular ; Evolutionary biology ; Gene Flow ; Genes ; Genetic diversity ; Genetic Variation ; Genetics ; Genome ; Genomes ; Genomics ; Genètica ; Haplotypes ; Monkeys & apes ; Nigeria ; Pan paniscus - genetics ; Pan troglodytes ; Pan troglodytes - genetics ; Population ; Population genetics ; Primatology ; Ximpanzés</subject><ispartof>Science (American Association for the Advancement of Science), 2016-10, Vol.354 (6311), p.477-481</ispartof><rights>Copyright © 2016 American Association for the Advancement of Science</rights><rights>Copyright © 2016, American Association for the Advancement of Science.</rights><rights>Copyright © 2016, American Association for the Advancement of Science</rights><rights>This is the author’s version of the work. It is posted here by permission of the AAAS for personal use, not for redistribution. The definitive version was published in Science on Volume 354, number 6311, 2016. DOI: 10.1126/science.aag2602 info:eu-repo/semantics/openAccess</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c551t-17949ff373f63bf501fed73ea2f039e647dd2ee5eb98711278a724fe230dd8013</citedby><cites>FETCH-LOGICAL-c551t-17949ff373f63bf501fed73ea2f039e647dd2ee5eb98711278a724fe230dd8013</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/44710895$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/44710895$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,776,780,799,881,2871,2872,26951,27901,27902,57992,58225</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27789843$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>de Manuel, Marc</creatorcontrib><creatorcontrib>Kuhlwilm, Martin</creatorcontrib><creatorcontrib>Frandsen, Peter</creatorcontrib><creatorcontrib>Sousa, Vitor C.</creatorcontrib><creatorcontrib>Desai, Tariq</creatorcontrib><creatorcontrib>Prado-Martinez, Javier</creatorcontrib><creatorcontrib>Hernandez-Rodriguez, Jessica</creatorcontrib><creatorcontrib>Dupanloup, Isabelle</creatorcontrib><creatorcontrib>Lao, Oscar</creatorcontrib><creatorcontrib>Hallast, Pille</creatorcontrib><creatorcontrib>Schmidt, Joshua M.</creatorcontrib><creatorcontrib>Heredia-Genestar, José María</creatorcontrib><creatorcontrib>Benazzo, Andrea</creatorcontrib><creatorcontrib>Barbujani, Guido</creatorcontrib><creatorcontrib>Peter, Benjamin M.</creatorcontrib><creatorcontrib>Kuderna, Lukas F. K.</creatorcontrib><creatorcontrib>Casals, Ferran</creatorcontrib><creatorcontrib>Angedakin, Samuel</creatorcontrib><creatorcontrib>Arandjelovic, Mimi</creatorcontrib><creatorcontrib>Boesch, Christophe</creatorcontrib><creatorcontrib>Kühl, Hjalmar</creatorcontrib><creatorcontrib>Vigilant, Linda</creatorcontrib><creatorcontrib>Langergraber, Kevin</creatorcontrib><creatorcontrib>Novembre, John</creatorcontrib><creatorcontrib>Gut, Marta</creatorcontrib><creatorcontrib>Gut, Ivo</creatorcontrib><creatorcontrib>Navarro, Arcadi</creatorcontrib><creatorcontrib>Carlsen, Frauds</creatorcontrib><creatorcontrib>Andres, Aida M.</creatorcontrib><creatorcontrib>Siegismund, Hans. R.</creatorcontrib><creatorcontrib>Scally, Aylwyn</creatorcontrib><creatorcontrib>Excoffier, Laurent</creatorcontrib><creatorcontrib>Tyler-Smith, Chris</creatorcontrib><creatorcontrib>Castellano, Sergi</creatorcontrib><creatorcontrib>Xue, Yali</creatorcontrib><creatorcontrib>Hvilsom, Christina</creatorcontrib><creatorcontrib>Marques-Bonet, Tomas</creatorcontrib><title>Chimpanzee genomic diversity reveals ancient admixture with bonobos</title><title>Science (American Association for the Advancement of Science)</title><addtitle>Science</addtitle><description>Our closest living relatives, chimpanzees and bonobos, have a complex demographic history. We analyzed the high-coverage whole genomes of 75 wild-born chimpanzees and bonobos from 10 countries in Africa. We found that chimpanzee population substructure makes genetic information a good predictor of geographic origin at country and regional scales. Multiple lines of evidence suggest that gene flow occurred from bonobos into the ancestors of central and eastern chimpanzees between 200,000 and 550,000 years ago, probably with subsequent spread into Nigeria-Cameroon chimpanzees. Together with another, possibly more recent contact (after 200,000 years ago), bonobos contributed less than 1% to the central chimpanzee genomes. Admixture thus appears to have been widespread during hominid evolution.</description><subject>Admixtures</subject><subject>Animal populations</subject><subject>Animals</subject><subject>Bonobo</subject><subject>Cameroon</subject><subject>Chimpanzees</subject><subject>Contact</subject><subject>Demographics</subject><subject>Evolució molecular</subject><subject>Evolution</subject><subject>Evolution, Molecular</subject><subject>Evolutionary biology</subject><subject>Gene Flow</subject><subject>Genes</subject><subject>Genetic diversity</subject><subject>Genetic Variation</subject><subject>Genetics</subject><subject>Genome</subject><subject>Genomes</subject><subject>Genomics</subject><subject>Genètica</subject><subject>Haplotypes</subject><subject>Monkeys & apes</subject><subject>Nigeria</subject><subject>Pan paniscus - genetics</subject><subject>Pan troglodytes</subject><subject>Pan troglodytes - genetics</subject><subject>Population</subject><subject>Population genetics</subject><subject>Primatology</subject><subject>Ximpanzés</subject><issn>0036-8075</issn><issn>1095-9203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>XX2</sourceid><recordid>eNqNks2P0zAQxS0EYkvhzAkUiQuX7I7t-OuChCq-pJW4wNlynEnrqomLnRSWv56Ehgo47cGyrPnNG8_TI-Q5hWtKmbzJPmDv8dq5LZPAHpAVBSNKw4A_JCsALksNSlyRJznvAaaa4Y_JFVNKG13xFdlsdqE7uv4nYrHFPnbBF004YcphuCsSntAdcuH6ec5QuKYLP4YxYfE9DLuijn2sY35KHrUThc-We02-vn_3ZfOxvP384dPm7W3phaBDSZWpTNtyxVvJ61YAbbFRHB1rgRuUlWoahiiwNlpN2yntFKtaZByaRgPla_LmrHsc6w4bP_0ouYM9ptC5dGejC_bfSh92dhtPVohKMsomAXoW8Hn0NqHH5N3wu_HymA8DxSznSkwWrcnrZWiK30bMg-1C9ng4uB7jmC3VshIVBWrugQpQUhsu74FyITVoPm_96j90H8fUT0bPFKdSGDoL3iyrpZhzwvZiCwU7R8UuUbFLVKaOl3-7eeH_ZGMCXpyBfR5iutSrSlHQRvBflO_FkA</recordid><startdate>20161028</startdate><enddate>20161028</enddate><creator>de Manuel, Marc</creator><creator>Kuhlwilm, Martin</creator><creator>Frandsen, Peter</creator><creator>Sousa, Vitor C.</creator><creator>Desai, Tariq</creator><creator>Prado-Martinez, Javier</creator><creator>Hernandez-Rodriguez, Jessica</creator><creator>Dupanloup, Isabelle</creator><creator>Lao, Oscar</creator><creator>Hallast, Pille</creator><creator>Schmidt, Joshua M.</creator><creator>Heredia-Genestar, José María</creator><creator>Benazzo, Andrea</creator><creator>Barbujani, Guido</creator><creator>Peter, Benjamin M.</creator><creator>Kuderna, Lukas F. 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K. ; Casals, Ferran ; Angedakin, Samuel ; Arandjelovic, Mimi ; Boesch, Christophe ; Kühl, Hjalmar ; Vigilant, Linda ; Langergraber, Kevin ; Novembre, John ; Gut, Marta ; Gut, Ivo ; Navarro, Arcadi ; Carlsen, Frauds ; Andres, Aida M. ; Siegismund, Hans. 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| fulltext | fulltext |
| identifier | ISSN: 0036-8075 |
| ispartof | Science (American Association for the Advancement of Science), 2016-10, Vol.354 (6311), p.477-481 |
| issn | 0036-8075 1095-9203 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5546212 |
| source | American Association for the Advancement of Science; Jstor Complete Legacy; MEDLINE; Recercat |
| subjects | Admixtures Animal populations Animals Bonobo Cameroon Chimpanzees Contact Demographics Evolució molecular Evolution Evolution, Molecular Evolutionary biology Gene Flow Genes Genetic diversity Genetic Variation Genetics Genome Genomes Genomics Genètica Haplotypes Monkeys & apes Nigeria Pan paniscus - genetics Pan troglodytes Pan troglodytes - genetics Population Population genetics Primatology Ximpanzés |
| title | Chimpanzee genomic diversity reveals ancient admixture with bonobos |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-08T03%3A36%3A08IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-jstor_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Chimpanzee%20genomic%20diversity%20reveals%20ancient%20admixture%20with%20bonobos&rft.jtitle=Science%20(American%20Association%20for%20the%20Advancement%20of%20Science)&rft.au=de%20Manuel,%20Marc&rft.date=2016-10-28&rft.volume=354&rft.issue=6311&rft.spage=477&rft.epage=481&rft.pages=477-481&rft.issn=0036-8075&rft.eissn=1095-9203&rft.coden=SCIEAS&rft_id=info:doi/10.1126/science.aag2602&rft_dat=%3Cjstor_pubme%3E44710895%3C/jstor_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1833165916&rft_id=info:pmid/27789843&rft_jstor_id=44710895&rfr_iscdi=true |