Influence of Human Papillomavirus Infection on the Natural History of Cervical Intraepithelial Neoplasia 1: A Meta-Analysis
Objective. To provide a scientific basis for the prevention and treatment of cervical intraepithelial neoplasia grade 1 (CIN1). This study evaluated the impact of human papillomavirus (HPV) infection on the natural history of CIN1. Methods. Electronic databases of Cochrane Library, EMBASE, PubMed, C...
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| Veröffentlicht in: | BioMed research international 2017-01, Vol.2017 (2017), p.1-9 |
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| creator | Li, Shugang Li, Xiaoju Zhang, Mei Yan, Xiaolong Liu, Mingzhu Jing, Mingxia |
| description | Objective. To provide a scientific basis for the prevention and treatment of cervical intraepithelial neoplasia grade 1 (CIN1). This study evaluated the impact of human papillomavirus (HPV) infection on the natural history of CIN1. Methods. Electronic databases of Cochrane Library, EMBASE, PubMed, CNKI, CBM, and Wanfang were searched in April 2016. The eligibility criteria were documented by Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). We used the Newcastle-Ottawa scale (NOS) to assess study quality. Results. Thirty-eight studies out of 3,246 identified papers were eligible for inclusion. The risk of CIN1 progression (relative risk [RR]: 3.04; 95% confidence interval [CI]: 2.41–3.83; P |
| doi_str_mv | 10.1155/2017/8971059 |
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To provide a scientific basis for the prevention and treatment of cervical intraepithelial neoplasia grade 1 (CIN1). This study evaluated the impact of human papillomavirus (HPV) infection on the natural history of CIN1. Methods. Electronic databases of Cochrane Library, EMBASE, PubMed, CNKI, CBM, and Wanfang were searched in April 2016. The eligibility criteria were documented by Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). We used the Newcastle-Ottawa scale (NOS) to assess study quality. Results. Thirty-eight studies out of 3,246 identified papers were eligible for inclusion. The risk of CIN1 progression (relative risk [RR]: 3.04; 95% confidence interval [CI]: 2.41–3.83; P<0.00001) and persistence (RR: 1.48; 95% CI: 1.17–1.87; P=0.001) was higher in the HPV-positive group than HPV-negative group. Specifically, the risk of CIN1 progression (RR: 13.91; 95% CI: 3.46–55.90; P=0.000) was higher among persistent high-risk HPV-positive patients and the ratio of CIN1 regression (RR: 0.65; 95% CI: 0.59–0.71; P<0.00001) was lower in the HPV-positive group than HPV-negative group. Conclusion. HPV infection resulted in an increased risk of CIN1 progression and decreased disease reversibility. Persistent high-risk HPV infection resulted in a further increased risk of CIN1 progression.</description><identifier>ISSN: 2314-6133</identifier><identifier>EISSN: 2314-6141</identifier><identifier>DOI: 10.1155/2017/8971059</identifier><identifier>PMID: 28812024</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>Adult ; Cellular biology ; Cervical cancer ; Cervical Intraepithelial Neoplasia - pathology ; Cervical Intraepithelial Neoplasia - prevention & control ; Cervical Intraepithelial Neoplasia - therapy ; Cervical Intraepithelial Neoplasia - virology ; Complications and side effects ; Confidence intervals ; Cost analysis ; Development and progression ; Disease ; Disease Progression ; Female ; Gynecology ; Health risk assessment ; Health risks ; Human papillomavirus ; Humans ; Infections ; Libraries ; Medical screening ; Meta-analysis ; Middle Aged ; Natural history ; Nitric-oxide synthase ; Obstetrics ; Papillomaviridae - pathogenicity ; Papillomavirus infections ; Papillomavirus Infections - pathology ; Papillomavirus Infections - prevention & control ; Papillomavirus Infections - therapy ; Papillomavirus Infections - virology ; Quality ; Quality assessment ; Regression analysis ; Review ; Risk ; Risk Factors ; Studies ; Vaccines</subject><ispartof>BioMed research international, 2017-01, Vol.2017 (2017), p.1-9</ispartof><rights>Copyright © 2017 Mingzhu Liu et al.</rights><rights>COPYRIGHT 2017 John Wiley & Sons, Inc.</rights><rights>Copyright © 2017 Mingzhu Liu et al.; This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</rights><rights>Copyright © 2017 Mingzhu Liu et al. 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c499t-9b71c0ef5b30113fef39c4cceb877e648f85ac9491239e17254f61f2a98591093</citedby><cites>FETCH-LOGICAL-c499t-9b71c0ef5b30113fef39c4cceb877e648f85ac9491239e17254f61f2a98591093</cites><orcidid>0000-0002-9278-6412 ; 0000-0003-4986-0127 ; 0000-0003-2649-9383</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5546131/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5546131/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28812024$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Lim, Myong Cheol</contributor><creatorcontrib>Li, Shugang</creatorcontrib><creatorcontrib>Li, Xiaoju</creatorcontrib><creatorcontrib>Zhang, Mei</creatorcontrib><creatorcontrib>Yan, Xiaolong</creatorcontrib><creatorcontrib>Liu, Mingzhu</creatorcontrib><creatorcontrib>Jing, Mingxia</creatorcontrib><title>Influence of Human Papillomavirus Infection on the Natural History of Cervical Intraepithelial Neoplasia 1: A Meta-Analysis</title><title>BioMed research international</title><addtitle>Biomed Res Int</addtitle><description>Objective. To provide a scientific basis for the prevention and treatment of cervical intraepithelial neoplasia grade 1 (CIN1). This study evaluated the impact of human papillomavirus (HPV) infection on the natural history of CIN1. Methods. Electronic databases of Cochrane Library, EMBASE, PubMed, CNKI, CBM, and Wanfang were searched in April 2016. The eligibility criteria were documented by Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). We used the Newcastle-Ottawa scale (NOS) to assess study quality. Results. Thirty-eight studies out of 3,246 identified papers were eligible for inclusion. The risk of CIN1 progression (relative risk [RR]: 3.04; 95% confidence interval [CI]: 2.41–3.83; P<0.00001) and persistence (RR: 1.48; 95% CI: 1.17–1.87; P=0.001) was higher in the HPV-positive group than HPV-negative group. Specifically, the risk of CIN1 progression (RR: 13.91; 95% CI: 3.46–55.90; P=0.000) was higher among persistent high-risk HPV-positive patients and the ratio of CIN1 regression (RR: 0.65; 95% CI: 0.59–0.71; P<0.00001) was lower in the HPV-positive group than HPV-negative group. Conclusion. HPV infection resulted in an increased risk of CIN1 progression and decreased disease reversibility. Persistent high-risk HPV infection resulted in a further increased risk of CIN1 progression.</description><subject>Adult</subject><subject>Cellular biology</subject><subject>Cervical cancer</subject><subject>Cervical Intraepithelial Neoplasia - pathology</subject><subject>Cervical Intraepithelial Neoplasia - prevention & control</subject><subject>Cervical Intraepithelial Neoplasia - therapy</subject><subject>Cervical Intraepithelial Neoplasia - virology</subject><subject>Complications and side effects</subject><subject>Confidence intervals</subject><subject>Cost analysis</subject><subject>Development and progression</subject><subject>Disease</subject><subject>Disease Progression</subject><subject>Female</subject><subject>Gynecology</subject><subject>Health risk assessment</subject><subject>Health risks</subject><subject>Human papillomavirus</subject><subject>Humans</subject><subject>Infections</subject><subject>Libraries</subject><subject>Medical screening</subject><subject>Meta-analysis</subject><subject>Middle Aged</subject><subject>Natural history</subject><subject>Nitric-oxide synthase</subject><subject>Obstetrics</subject><subject>Papillomaviridae - pathogenicity</subject><subject>Papillomavirus infections</subject><subject>Papillomavirus Infections - pathology</subject><subject>Papillomavirus Infections - prevention & control</subject><subject>Papillomavirus Infections - therapy</subject><subject>Papillomavirus Infections - virology</subject><subject>Quality</subject><subject>Quality assessment</subject><subject>Regression analysis</subject><subject>Review</subject><subject>Risk</subject><subject>Risk Factors</subject><subject>Studies</subject><subject>Vaccines</subject><issn>2314-6133</issn><issn>2314-6141</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqNkc1v0zAYxiMEYtPYjTOKxAUJwvz6I4k5IFUVrJXG4ABny_Ver57cONhJUcU_j7OWMjhhWfLXz8_rx09RPAfyFkCIC0qguWhlA0TIR8UpZcCrGjg8Ps4ZOynOU7ojubVQE1k_LU5o2wIllJ8WP5ed9SN2Bstgy8W40V35RffO-7DRWxfHVGYCzeBCV-Y-rLG81sMYtS8XLg0h7qaLc4xbZ_Leshuixt5lzru8vsbQe52cLuFdOSs_4aCrWaf9Lrn0rHhitU94fhjPim8fP3ydL6qrz5fL-eyqMlzKoZKrBgxBK1aMADCLlknDjcFV2zRY89a2QhvJJVAmERoquK3BUi1bIYFIdla83-v242qDNwanN3rVR7fRcaeCdurvk86t1W3YKiF4_kDIAq8OAjF8HzENauOSQe91h2FMCiSVOQQJU62X_6B3YYzZ8D1Vc5otPaButUflOhtyXTOJqpkQDSOMUJapN3vKxJBSRHt8MhA1xa-m-NUh_oy_eGjzCP8OOwOv98DadTf6h_tPOcwMWv2HBpb9CvYL6pDAZg</recordid><startdate>20170101</startdate><enddate>20170101</enddate><creator>Li, Shugang</creator><creator>Li, Xiaoju</creator><creator>Zhang, Mei</creator><creator>Yan, Xiaolong</creator><creator>Liu, Mingzhu</creator><creator>Jing, Mingxia</creator><general>Hindawi Publishing Corporation</general><general>Hindawi</general><general>John Wiley & Sons, Inc</general><general>Hindawi Limited</general><scope>ADJCN</scope><scope>AHFXO</scope><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7QO</scope><scope>7T7</scope><scope>7TK</scope><scope>7U7</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>CWDGH</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-9278-6412</orcidid><orcidid>https://orcid.org/0000-0003-4986-0127</orcidid><orcidid>https://orcid.org/0000-0003-2649-9383</orcidid></search><sort><creationdate>20170101</creationdate><title>Influence of Human Papillomavirus Infection on the Natural History of Cervical Intraepithelial Neoplasia 1: A Meta-Analysis</title><author>Li, Shugang ; Li, Xiaoju ; Zhang, Mei ; Yan, Xiaolong ; Liu, Mingzhu ; Jing, Mingxia</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c499t-9b71c0ef5b30113fef39c4cceb877e648f85ac9491239e17254f61f2a98591093</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adult</topic><topic>Cellular biology</topic><topic>Cervical cancer</topic><topic>Cervical Intraepithelial Neoplasia - pathology</topic><topic>Cervical Intraepithelial Neoplasia - prevention & control</topic><topic>Cervical Intraepithelial Neoplasia - therapy</topic><topic>Cervical Intraepithelial Neoplasia - virology</topic><topic>Complications and side effects</topic><topic>Confidence intervals</topic><topic>Cost analysis</topic><topic>Development and progression</topic><topic>Disease</topic><topic>Disease Progression</topic><topic>Female</topic><topic>Gynecology</topic><topic>Health risk assessment</topic><topic>Health risks</topic><topic>Human papillomavirus</topic><topic>Humans</topic><topic>Infections</topic><topic>Libraries</topic><topic>Medical screening</topic><topic>Meta-analysis</topic><topic>Middle Aged</topic><topic>Natural history</topic><topic>Nitric-oxide synthase</topic><topic>Obstetrics</topic><topic>Papillomaviridae - pathogenicity</topic><topic>Papillomavirus infections</topic><topic>Papillomavirus Infections - pathology</topic><topic>Papillomavirus Infections - prevention & control</topic><topic>Papillomavirus Infections - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>BioMed research international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Shugang</au><au>Li, Xiaoju</au><au>Zhang, Mei</au><au>Yan, Xiaolong</au><au>Liu, Mingzhu</au><au>Jing, Mingxia</au><au>Lim, Myong Cheol</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Influence of Human Papillomavirus Infection on the Natural History of Cervical Intraepithelial Neoplasia 1: A Meta-Analysis</atitle><jtitle>BioMed research international</jtitle><addtitle>Biomed Res Int</addtitle><date>2017-01-01</date><risdate>2017</risdate><volume>2017</volume><issue>2017</issue><spage>1</spage><epage>9</epage><pages>1-9</pages><issn>2314-6133</issn><eissn>2314-6141</eissn><abstract>Objective. To provide a scientific basis for the prevention and treatment of cervical intraepithelial neoplasia grade 1 (CIN1). This study evaluated the impact of human papillomavirus (HPV) infection on the natural history of CIN1. Methods. Electronic databases of Cochrane Library, EMBASE, PubMed, CNKI, CBM, and Wanfang were searched in April 2016. The eligibility criteria were documented by Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). We used the Newcastle-Ottawa scale (NOS) to assess study quality. Results. Thirty-eight studies out of 3,246 identified papers were eligible for inclusion. The risk of CIN1 progression (relative risk [RR]: 3.04; 95% confidence interval [CI]: 2.41–3.83; P<0.00001) and persistence (RR: 1.48; 95% CI: 1.17–1.87; P=0.001) was higher in the HPV-positive group than HPV-negative group. Specifically, the risk of CIN1 progression (RR: 13.91; 95% CI: 3.46–55.90; P=0.000) was higher among persistent high-risk HPV-positive patients and the ratio of CIN1 regression (RR: 0.65; 95% CI: 0.59–0.71; P<0.00001) was lower in the HPV-positive group than HPV-negative group. Conclusion. HPV infection resulted in an increased risk of CIN1 progression and decreased disease reversibility. Persistent high-risk HPV infection resulted in a further increased risk of CIN1 progression.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Publishing Corporation</pub><pmid>28812024</pmid><doi>10.1155/2017/8971059</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-9278-6412</orcidid><orcidid>https://orcid.org/0000-0003-4986-0127</orcidid><orcidid>https://orcid.org/0000-0003-2649-9383</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Cellular biology Cervical cancer Cervical Intraepithelial Neoplasia - pathology Cervical Intraepithelial Neoplasia - prevention & control Cervical Intraepithelial Neoplasia - therapy Cervical Intraepithelial Neoplasia - virology Complications and side effects Confidence intervals Cost analysis Development and progression Disease Disease Progression Female Gynecology Health risk assessment Health risks Human papillomavirus Humans Infections Libraries Medical screening Meta-analysis Middle Aged Natural history Nitric-oxide synthase Obstetrics Papillomaviridae - pathogenicity Papillomavirus infections Papillomavirus Infections - pathology Papillomavirus Infections - prevention & control Papillomavirus Infections - therapy Papillomavirus Infections - virology Quality Quality assessment Regression analysis Review Risk Risk Factors Studies Vaccines |
| title | Influence of Human Papillomavirus Infection on the Natural History of Cervical Intraepithelial Neoplasia 1: A Meta-Analysis |
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