Mechanistic elucidation of the mycofactocin-biosynthetic radical S-adenosylmethionine protein, MftC

Ribosomally synthesized and posttranslationally modified peptide (RiPP) pathways produce a diverse array of natural products. A subset of these pathways depends on radical S-adenosylmethionine proteins to modify the RiPP-produced peptide. Mycofactocin biosynthesis is one example of an S-adenosylmeth...

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Veröffentlicht in:	The Journal of biological chemistry 2017-08, Vol.292 (31), p.13022-13033
Hauptverfasser:	Khaliullin, Bulat, Ayikpoe, Richard, Tuttle, Mason, Latham, John A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Substitution Bacterial Proteins - chemistry Bacterial Proteins - genetics Bacterial Proteins - metabolism Biocatalysis Carboxy-Lyases - chemistry Carboxy-Lyases - genetics Carboxy-Lyases - metabolism Chromatography, High Pressure Liquid Decarboxylation enzyme mechanism Enzymology iron-sulfur protein MftC Molecular Chaperones - chemistry Molecular Chaperones - genetics Molecular Chaperones - metabolism Mutagenesis, Site-Directed Mutation Mycobacterium ulcerans - enzymology Mycobacterium ulcerans - metabolism mycofactocin Nuclear Magnetic Resonance, Biomolecular Oxidation-Reduction peptide biosynthesis Protein Interaction Domains and Motifs Protein Precursors - chemistry Protein Precursors - genetics Protein Precursors - metabolism radical Recombinant Fusion Proteins - chemistry Recombinant Fusion Proteins - metabolism S-adenosylmethionine (SAM) S-Adenosylmethionine - metabolism Spectrometry, Mass, Electrospray Ionization Stereoisomerism Tandem Mass Spectrometry Tyramine - chemistry Tyramine - metabolism Tyrosine - chemistry Tyrosine - metabolism Valine - chemistry Valine - metabolism
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