The Dlk1-Gtl2 Locus Preserves LT-HSC Function by Inhibiting the PI3K-mTOR Pathway to Restrict Mitochondrial Metabolism

The mammalian imprinted Dlk1-Gtl2 locus produces multiple non-coding RNAs (ncRNAs) from the maternally inherited allele, including the largest miRNA cluster in the mammalian genome. This locus has characterized functions in some types of stem cell, but its role in hematopoietic stem cells (HSCs) is...

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Veröffentlicht in:	Cell stem cell 2016-02, Vol.18 (2), p.214-228
Hauptverfasser:	Qian, Pengxu, He, Xi C., Paulson, Ariel, Li, Zhenrui, Tao, Fang, Perry, John M., Guo, Fengli, Zhao, Meng, Zhi, Lei, Venkatraman, Aparna, Haug, Jeffrey S., Parmely, Tari, Li, Hua, Dobrowsky, Rick T., Ding, Wen-Xing, Kono, Tomohiro, Ferguson-Smith, Anne C., Li, Linheng
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcysteine - pharmacology Animals Antigens, CD - metabolism Calcium-Binding Proteins Fetus - metabolism Genetic Loci Genomic Imprinting HEK293 Cells Hematopoietic Stem Cells - metabolism Humans Intercellular Signaling Peptides and Proteins - metabolism Liver - cytology Liver - embryology Mice, Inbred C57BL MicroRNAs - genetics MicroRNAs - metabolism Mitochondria - metabolism Mitochondria - ultrastructure Mutation - genetics Organelle Biogenesis Phosphatidylinositol 3-Kinases - metabolism Reactive Oxygen Species - metabolism RNA, Long Noncoding - metabolism Signal Transduction Sirolimus - pharmacology TOR Serine-Threonine Kinases - metabolism
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