Efficient cationic lipid-mediated delivery of antisense oligonucleotides into eukaryotic cells: down-regulation of the corticotropin-releasing factor receptor

Oligonucleotides (ODNs) can be employed as effective gene-specific regulators. However, before ODNs can reach their targets, several physical barriers have to be overcome, as although ODNs may pass cell membranes, most become sequestered in endocytic compartments. Accordingly, sophisticated strategi...

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Veröffentlicht in:	Nucleic acids research 2001-05, Vol.29 (10), p.2079-2087
Hauptverfasser:	Shi, F, Nomden, A, Oberle, V, Engberts, J B, Hoekstra, D
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological Transport - drug effects Blood Proteins - metabolism Blood Proteins - pharmacology Blotting, Western Cations - administration & dosage Cations - metabolism Cations - toxicity Cell Death - drug effects Cell Nucleus - drug effects Cell Nucleus - metabolism CHO Cells Cricetinae Cytoplasm - drug effects Cytoplasm - metabolism Down-Regulation - drug effects Endosomes - metabolism Eukaryotic Cells - drug effects Eukaryotic Cells - metabolism Formazans Glycerophospholipids - metabolism Kinetics Liposomes - chemistry Liposomes - metabolism Liposomes - toxicity Lysosomes - metabolism Oligonucleotides, Antisense - administration & dosage Oligonucleotides, Antisense - genetics Oligonucleotides, Antisense - metabolism Phosphatidylethanolamines Pyridinium Compounds - administration & dosage Pyridinium Compounds - metabolism Pyridinium Compounds - toxicity Receptors, Corticotropin-Releasing Hormone - biosynthesis Receptors, Corticotropin-Releasing Hormone - genetics Receptors, Corticotropin-Releasing Hormone - metabolism RNA, Messenger - genetics RNA, Messenger - metabolism Tetrazolium Salts
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