Effect of Methotrexate on an In Vitro Patient-Derived Model of Proliferative Vitreoretinopathy

The purpose of this study was to develop a method for isolating, culturing, and characterizing cells from patient-derived membranes in proliferative vitreoretinopathy (PVR) to be used for drug testing. PVR membranes were obtained from six patients with grade C PVR. Membrane fragments were analyzed b...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Investigative ophthalmology & visual science 2017-08, Vol.58 (10), p.3940-3949
Hauptverfasser:	Amarnani, Dhanesh, Machuca-Parra, Arturo Israel, Wong, Lindsay L, Marko, Christina K, Stefater, James A, Stryjewski, Tomasz P, Eliott, Dean, Arboleda-Velasquez, Joseph F, Kim, Leo A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Apoptosis - drug effects Biomarkers - metabolism Cell Culture Techniques Cell Movement - physiology Cell Proliferation - physiology Cell Separation Epiretinal Membrane - drug therapy Epiretinal Membrane - metabolism Epiretinal Membrane - pathology Extracellular Matrix Proteins - metabolism Female Fluorescent Antibody Technique, Indirect Humans Immunosuppressive Agents - pharmacology Male Methotrexate - pharmacology Middle Aged Models, Biological Phenotype Retina Retinal Detachment - complications Retinal Pigment Epithelium - drug effects Retinal Pigment Epithelium - metabolism Retinal Pigment Epithelium - pathology Tumor Necrosis Factor-alpha - pharmacology Vitreoretinopathy, Proliferative - drug therapy Vitreoretinopathy, Proliferative - etiology Vitreoretinopathy, Proliferative - metabolism Vitreoretinopathy, Proliferative - pathology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!