Common features of polyomavirus mutants selected on PCC4 embryonal carcinoma cells
The genomic rearrangements of six polyomavirus mutants selected on PCC4 embryonal carcinoma cells have been compared and their common characteristics pointed out. All mutants show a duplication which includes at least the adenovirus type 5 (Ad5) E1A‐like enhancer core sequence plus a deletion of var...
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| Veröffentlicht in: | The EMBO journal 1985-07, Vol.4 (7), p.1799-1803 |
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| container_title | The EMBO journal |
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| creator | Melin, F. Pinon, H. Reiss, C. Kress, C. Montreau, N. Blangy, D. |
| description | The genomic rearrangements of six polyomavirus mutants selected on PCC4 embryonal carcinoma cells have been compared and their common characteristics pointed out. All mutants show a duplication which includes at least the adenovirus type 5 (Ad5) E1A‐like enhancer core sequence plus a deletion of variable size and location. The presence of the second enhancer core sequence, the SV40‐like enhancer, is not required for expression of the PyEC PCC4 phenotype. Two of these mutants are also able to express polyomavirus T antigen on F9 and LT1 cells. Multiadaptation seems to require the duplication of the Ad5 E1A‐like core sequence, the maintenance of the SV40‐like core sequence and a local change in DNA stability. |
| doi_str_mv | 10.1002/j.1460-2075.1985.tb03853.x |
| format | Article |
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All mutants show a duplication which includes at least the adenovirus type 5 (Ad5) E1A‐like enhancer core sequence plus a deletion of variable size and location. The presence of the second enhancer core sequence, the SV40‐like enhancer, is not required for expression of the PyEC PCC4 phenotype. Two of these mutants are also able to express polyomavirus T antigen on F9 and LT1 cells. 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All mutants show a duplication which includes at least the adenovirus type 5 (Ad5) E1A‐like enhancer core sequence plus a deletion of variable size and location. The presence of the second enhancer core sequence, the SV40‐like enhancer, is not required for expression of the PyEC PCC4 phenotype. Two of these mutants are also able to express polyomavirus T antigen on F9 and LT1 cells. Multiadaptation seems to require the duplication of the Ad5 E1A‐like core sequence, the maintenance of the SV40‐like core sequence and a local change in DNA stability.</description><subject>Animals</subject><subject>Base Sequence</subject><subject>Biological and medical sciences</subject><subject>Cell Line</subject><subject>Cloning, Molecular</subject><subject>DNA Restriction Enzymes</subject><subject>Fundamental and applied biological sciences. 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Psychology</topic><topic>Genetics</topic><topic>Mice</topic><topic>Microbiology</topic><topic>Mutation</topic><topic>Polyomavirus - genetics</topic><topic>Teratoma - microbiology</topic><topic>Virology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Melin, F.</creatorcontrib><creatorcontrib>Pinon, H.</creatorcontrib><creatorcontrib>Reiss, C.</creatorcontrib><creatorcontrib>Kress, C.</creatorcontrib><creatorcontrib>Montreau, N.</creatorcontrib><creatorcontrib>Blangy, D.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The EMBO journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Melin, F.</au><au>Pinon, H.</au><au>Reiss, C.</au><au>Kress, C.</au><au>Montreau, N.</au><au>Blangy, D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Common features of polyomavirus mutants selected on PCC4 embryonal carcinoma cells</atitle><jtitle>The EMBO journal</jtitle><addtitle>EMBO J</addtitle><date>1985-07</date><risdate>1985</risdate><volume>4</volume><issue>7</issue><spage>1799</spage><epage>1803</epage><pages>1799-1803</pages><issn>0261-4189</issn><eissn>1460-2075</eissn><coden>EMJODG</coden><abstract>The genomic rearrangements of six polyomavirus mutants selected on PCC4 embryonal carcinoma cells have been compared and their common characteristics pointed out. All mutants show a duplication which includes at least the adenovirus type 5 (Ad5) E1A‐like enhancer core sequence plus a deletion of variable size and location. The presence of the second enhancer core sequence, the SV40‐like enhancer, is not required for expression of the PyEC PCC4 phenotype. Two of these mutants are also able to express polyomavirus T antigen on F9 and LT1 cells. Multiadaptation seems to require the duplication of the Ad5 E1A‐like core sequence, the maintenance of the SV40‐like core sequence and a local change in DNA stability.</abstract><cop>London</cop><pub>Nature Publishing Group</pub><pmid>2992943</pmid><doi>10.1002/j.1460-2075.1985.tb03853.x</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection; Free Full-Text Journals in Chemistry |
| subjects | Animals Base Sequence Biological and medical sciences Cell Line Cloning, Molecular DNA Restriction Enzymes Fundamental and applied biological sciences. Psychology Genetics Mice Microbiology Mutation Polyomavirus - genetics Teratoma - microbiology Virology |
| title | Common features of polyomavirus mutants selected on PCC4 embryonal carcinoma cells |
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