A consolidated catalogue and graphical annotation of dbSNP polymorphisms in the human tissue kallikrein ( KLK) locus
The human tissue kallikreins, 15 secreted serine proteases, may play diverse roles in pathophysiology. The National Center for Biotechnology Information's dbSNP was mined for polymorphisms located within the kallikrein ( KLK) locus using custom-designed “ParSNPs” and “LocusAnnotator” software t...
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| Veröffentlicht in: | Molecular oncology 2007-12, Vol.1 (3), p.303-312 |
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| creator | Goard, Carolyn A. Bromberg, Irvin L. Elliott, Marc B. Diamandis, Eleftherios P. |
| description | The human tissue kallikreins, 15 secreted serine proteases, may play diverse roles in pathophysiology. The National Center for Biotechnology Information's dbSNP was mined for polymorphisms located within the kallikrein (
KLK) locus using custom-designed “ParSNPs” and “LocusAnnotator” software tools. Using “ParSNPs”, a filterable catalogue of 1856
KLK polymorphisms (1023 validated) was generated. “LocusAnnotator” was used to annotate the
KLK locus sequence with gene and polymorphism features. A second locus was examined to validate the use of both programs on a non-kallikrein locus. This report may assist in the informed selection of
KLK polymorphisms for future association and biochemical studies in relation to disease. Furthermore, “ParSNPs” and “LocusAnnotator” are available at no cost from our website (
www.acdcLab.org/annotations) to examine other loci. |
| doi_str_mv | 10.1016/j.molonc.2007.09.001 |
| format | Article |
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KLK) locus using custom-designed “ParSNPs” and “LocusAnnotator” software tools. Using “ParSNPs”, a filterable catalogue of 1856
KLK polymorphisms (1023 validated) was generated. “LocusAnnotator” was used to annotate the
KLK locus sequence with gene and polymorphism features. A second locus was examined to validate the use of both programs on a non-kallikrein locus. This report may assist in the informed selection of
KLK polymorphisms for future association and biochemical studies in relation to disease. Furthermore, “ParSNPs” and “LocusAnnotator” are available at no cost from our website (
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KLK) locus using custom-designed “ParSNPs” and “LocusAnnotator” software tools. Using “ParSNPs”, a filterable catalogue of 1856
KLK polymorphisms (1023 validated) was generated. “LocusAnnotator” was used to annotate the
KLK locus sequence with gene and polymorphism features. A second locus was examined to validate the use of both programs on a non-kallikrein locus. This report may assist in the informed selection of
KLK polymorphisms for future association and biochemical studies in relation to disease. Furthermore, “ParSNPs” and “LocusAnnotator” are available at no cost from our website (
www.acdcLab.org/annotations) to examine other loci.</description><subject>Annotations</subject><subject>Biotechnology</subject><subject>Chromosome Mapping</subject><subject>Chromosomes, Human, Pair 19</subject><subject>Codon, Initiator</subject><subject>Codon, Terminator</subject><subject>Databases, Genetic</subject><subject>Exons</subject><subject>Gene loci</subject><subject>Gene polymorphism</subject><subject>Genetic polymorphism</subject><subject>Genomes</subject><subject>Humans</subject><subject>Introns</subject><subject>Kallikrein</subject><subject>Kallikreins</subject><subject>Polymorphism</subject><subject>Polymorphism, Genetic</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Population</subject><subject>Prostate cancer</subject><subject>Reproducibility of Results</subject><subject>RNA, Messenger - genetics</subject><subject>Serine</subject><subject>Single nucleotide polymorphism</subject><subject>Software</subject><subject>Studies</subject><subject>TATA Box</subject><subject>Tissue kallikrein</subject><subject>Tissue Kallikreins - genetics</subject><issn>1574-7891</issn><issn>1878-0261</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqNkU1v1DAQhiMEoqXwDxCyhITgkDC2E9u5gKqqfKgLRQLOluM4u9469mInrfbf42VXFDgAJ8_Izzyy5y2KxxgqDJi9XFdjcMHrigDwCtoKAN8pjrHgogTC8N1cN7wuuWjxUfEgpTVAw1rW3i-OcEsFpVAfF9Mp0sGn4GyvJtMjrSblwnI2SPkeLaParKxWLnc-TGqywaMwoL77_PET2gS3HUPMRBoTsh5NK4NW86hyZVPKjivlnL2KJt89RxeLixfIBT2nh8W9QblkHh3Ok-Lrm_MvZ-_KxeXb92eni1I3nNGSc6NwjWvAvNNKdEoJPmhaazBABdTDQJqMdBSzvqGsE6IlIDpB-04Rwlp6UrzaezdzN5peGz9F5eQm2lHFrQzKyt9vvF3JZbiWTVNTwVgWPDsIYvg2mzTJ0SZtnFPehDlJDriuQZB_ggQa4IztwKd_gOswR5-3IAlpW8wF_qGr95SOIaVohp9vxiB36cu13Kcvd-lLaGVOP489-fW_t0OHuDPweg_cWGe2_yWVHy4XZNfjbKC3KzU5t2trokzaGq9Nb6PRk-yD_fsbvwPVHdbX</recordid><startdate>200712</startdate><enddate>200712</enddate><creator>Goard, Carolyn A.</creator><creator>Bromberg, Irvin L.</creator><creator>Elliott, Marc B.</creator><creator>Diamandis, Eleftherios P.</creator><general>Elsevier B.V</general><general>John Wiley & Sons, Inc</general><general>John Wiley and Sons Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FE</scope><scope>8FH</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>LK8</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>200712</creationdate><title>A consolidated catalogue and graphical annotation of dbSNP polymorphisms in the human tissue kallikrein ( KLK) locus</title><author>Goard, Carolyn A. ; Bromberg, Irvin L. ; Elliott, Marc B. ; Diamandis, Eleftherios P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5763-77ea1414017bca8baa87fc34c0e03804ff257eab316d536b889208b83dba22693</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Annotations</topic><topic>Biotechnology</topic><topic>Chromosome Mapping</topic><topic>Chromosomes, Human, Pair 19</topic><topic>Codon, Initiator</topic><topic>Codon, Terminator</topic><topic>Databases, Genetic</topic><topic>Exons</topic><topic>Gene loci</topic><topic>Gene polymorphism</topic><topic>Genetic polymorphism</topic><topic>Genomes</topic><topic>Humans</topic><topic>Introns</topic><topic>Kallikrein</topic><topic>Kallikreins</topic><topic>Polymorphism</topic><topic>Polymorphism, Genetic</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Population</topic><topic>Prostate cancer</topic><topic>Reproducibility of Results</topic><topic>RNA, Messenger - genetics</topic><topic>Serine</topic><topic>Single nucleotide polymorphism</topic><topic>Software</topic><topic>Studies</topic><topic>TATA Box</topic><topic>Tissue kallikrein</topic><topic>Tissue Kallikreins - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Goard, Carolyn A.</creatorcontrib><creatorcontrib>Bromberg, Irvin L.</creatorcontrib><creatorcontrib>Elliott, Marc B.</creatorcontrib><creatorcontrib>Diamandis, Eleftherios P.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Biological Science Database</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Molecular oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Goard, Carolyn A.</au><au>Bromberg, Irvin L.</au><au>Elliott, Marc B.</au><au>Diamandis, Eleftherios P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A consolidated catalogue and graphical annotation of dbSNP polymorphisms in the human tissue kallikrein ( KLK) locus</atitle><jtitle>Molecular oncology</jtitle><addtitle>Mol Oncol</addtitle><date>2007-12</date><risdate>2007</risdate><volume>1</volume><issue>3</issue><spage>303</spage><epage>312</epage><pages>303-312</pages><issn>1574-7891</issn><eissn>1878-0261</eissn><abstract>The human tissue kallikreins, 15 secreted serine proteases, may play diverse roles in pathophysiology. The National Center for Biotechnology Information's dbSNP was mined for polymorphisms located within the kallikrein (
KLK) locus using custom-designed “ParSNPs” and “LocusAnnotator” software tools. Using “ParSNPs”, a filterable catalogue of 1856
KLK polymorphisms (1023 validated) was generated. “LocusAnnotator” was used to annotate the
KLK locus sequence with gene and polymorphism features. A second locus was examined to validate the use of both programs on a non-kallikrein locus. This report may assist in the informed selection of
KLK polymorphisms for future association and biochemical studies in relation to disease. Furthermore, “ParSNPs” and “LocusAnnotator” are available at no cost from our website (
www.acdcLab.org/annotations) to examine other loci.</abstract><cop>United States</cop><pub>Elsevier B.V</pub><pmid>19383304</pmid><doi>10.1016/j.molonc.2007.09.001</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1574-7891 |
| ispartof | Molecular oncology, 2007-12, Vol.1 (3), p.303-312 |
| issn | 1574-7891 1878-0261 |
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| subjects | Annotations Biotechnology Chromosome Mapping Chromosomes, Human, Pair 19 Codon, Initiator Codon, Terminator Databases, Genetic Exons Gene loci Gene polymorphism Genetic polymorphism Genomes Humans Introns Kallikrein Kallikreins Polymorphism Polymorphism, Genetic Polymorphism, Single Nucleotide Population Prostate cancer Reproducibility of Results RNA, Messenger - genetics Serine Single nucleotide polymorphism Software Studies TATA Box Tissue kallikrein Tissue Kallikreins - genetics |
| title | A consolidated catalogue and graphical annotation of dbSNP polymorphisms in the human tissue kallikrein ( KLK) locus |
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