Rare cell variability and drug-induced reprogramming as a mode of cancer drug resistance

Through drug exposure, a rare, transient transcriptional program characterized by high levels of expression of known resistance drivers can get ‘burned in’, leading to the selection of cells endowed with a transcriptional drug resistance and thus more chemoresistant cancers. Therapies that target si...

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Veröffentlicht in:	Nature (London) 2017-06, Vol.546 (7658), p.431-435
Hauptverfasser:	Shaffer, Sydney M., Dunagin, Margaret C., Torborg, Stefan R., Torre, Eduardo A., Emert, Benjamin, Krepler, Clemens, Beqiri, Marilda, Sproesser, Katrin, Brafford, Patricia A., Xiao, Min, Eggan, Elliott, Anastopoulos, Ioannis N., Vargas-Garcia, Cesar A., Singh, Abhyudai, Nathanson, Katherine L., Herlyn, Meenhard, Raj, Arjun
Format:	Artikel
Sprache:	eng
Schlagworte:	14/32 38/32 38/39 38/91 45/23 631/553/2706 631/553/2707 631/67/1059/2326 Activator protein 1 Animals Antineoplastic agents Cancer Cell interactions Cell Line, Tumor Cellular Reprogramming - drug effects Cellular Reprogramming - genetics Chemotherapy Deoxyribonucleic acid Differentiation DNA DNA-Binding Proteins - metabolism Dosage and administration Drug resistance Drug Resistance, Neoplasm - drug effects Drug Resistance, Neoplasm - genetics Epigenesis, Genetic - drug effects ErbB Receptors - metabolism Female Gene expression Gene Expression Regulation, Neoplastic - drug effects Genetic Markers - drug effects Genetic Markers - genetics Genomes Health aspects Humanities and Social Sciences Humans In Situ Hybridization, Fluorescence Indoles - pharmacology Kinases letter Male Melanoma Melanoma - genetics Melanoma - pathology multidisciplinary Mutation Nuclear Proteins - metabolism Observations Oncogene Protein p65(gag-jun) - metabolism Population Science Signal transduction Signal Transduction - drug effects Signal Transduction - genetics Signaling Single-Cell Analysis Sox10 protein SOXE Transcription Factors - deficiency SOXE Transcription Factors - genetics Subpopulations Substance abuse treatment Sulfonamides - pharmacology TEA Domain Transcription Factors Transcription Factor AP-1 - metabolism Transcription factors Transcription Factors - metabolism Transcription, Genetic - drug effects Vemurafenib Xenograft Model Antitumor Assays
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