Clonal hematopoiesis associated with TET2 deficiency accelerates atherosclerosis development in mice

Human aging is associated with an increased frequency of somatic mutations in hematopoietic cells. Several of these recurrent mutations, including those in the gene encoding the epigenetic modifier enzyme TET2, promote expansion of the mutant blood cells. This clonal hematopoiesis correlates with an...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2017-02, Vol.355 (6327), p.842-847
Hauptverfasser:	Fuster, José J., MacLauchlan, Susan, Zuriaga, María A., Polackal, Maya N., Ostriker, Allison C., Chakraborty, Raja, Wu, Chia-Ling, Sano, Soichi, Muralidharan, Sujatha, Rius, Cristina, Vuong, Jacqueline, Jacob, Sophia, Muralidhar, Varsha, Robertson, Avril A. B., Cooper, Matthew A., Andrés, Vicente, Hirschi, Karen K., Martin, Kathleen A., Walsh, Kenneth
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Animals Arteriosclerosis Atherosclerosis Atherosclerosis - genetics Blood Blood cancer Blood cells Bone marrow Cardiovascular disease Cardiovascular diseases Cloning Cytokines DNA-Binding Proteins - genetics Epigenetics Genes Health risks Heart diseases Hematological diseases Hematopoiesis Hematopoiesis - genetics Hematopoietic Stem Cells - metabolism Hemopoietic system Inflammasomes Inflammasomes - metabolism Interleukin 1 Macrophages Mice Mice, Inbred C57BL Mutation Mutations NLR Family, Pyrin Domain-Containing 3 Protein - metabolism Older people Plaque, Atherosclerotic - genetics Proto-Oncogene Proteins - genetics Receptors, LDL - genetics Regulators Rodents Secretions
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