Somatostatin alters beta‐adrenergic receptor‐effector coupling in cultured rat astrocytes

The neuropeptide somatostatin potentiates beta‐adrenergic receptor‐mediated cAMP formation in astrocytes derived from neonatal rat cortex but does not affect cAMP levels by itself. beta‐Adrenergic receptors in these cells can be specifically labeled with the high affinity antagonist [125I] cyanopind...

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Veröffentlicht in:	The EMBO journal 1985-02, Vol.4 (2), p.317-321
Hauptverfasser:	Niehoff, D.L., Mudge, A.W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenylyl Cyclases - metabolism Animals Astrocytes - drug effects Astrocytes - metabolism Biological and medical sciences Cell physiology Cells, Cultured Cerebral Cortex - cytology Cyclic AMP - biosynthesis Fundamental and applied biological sciences. Psychology GTP-Binding Proteins - metabolism Iodocyanopindolol Isoproterenol - metabolism Molecular and cellular biology Neurotransmission Pindolol - analogs & derivatives Rats Receptors, Adrenergic, beta - drug effects Somatostatin - pharmacology
Online-Zugang:	Volltext
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