Cell-to-cell heterogeneity of EWSR1-FLI1 activity determines proliferation/migration choices in Ewing sarcoma cells

Ewing sarcoma is characterized by the expression of the chimeric EWSR1-FLI1 transcription factor. Proteomic analyses indicate that the decrease of EWSR1-FLI1 expression leads to major changes in effectors of the dynamics of the actin cytoskeleton and the adhesion processes with a shift from cell-to-...

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Veröffentlicht in:	Oncogene 2017-06, Vol.36 (25), p.3505-3514
Hauptverfasser:	Franzetti, G-A, Laud-Duval, K, van der Ent, W, Brisac, A, Irondelle, M, Aubert, S, Dirksen, U, Bouvier, C, de Pinieux, G, Snaar-Jagalska, E, Chavrier, P, Delattre, O
Format:	Artikel
Sprache:	eng
Schlagworte:	13/1 13/31 13/51 13/89 14/34 14/63 38/77 631/67/1798 631/67/2329 631/67/322 631/67/70 631/80/84 64/116 64/60 82/29 82/58 96/109 Actin Animals Apoptosis Calmodulin-Binding Proteins - biosynthesis Calmodulin-Binding Proteins - genetics Cancer Care and treatment Cell adhesion & migration Cell Biology Cell Line, Tumor Cell migration Cell Movement Cell Proliferation Cytoskeleton Development and progression Ewing's sarcoma Ewings sarcoma FLI-1 protein Gene expression Gene Expression Regulation, Neoplastic Genetic aspects Health aspects Human Genetics Immunofluorescence Internal Medicine Medicine Medicine & Public Health Mice Mice, SCID Neoplasm Invasiveness Neoplasm Metastasis Oncogene Proteins, Fusion - biosynthesis Oncogene Proteins, Fusion - genetics Oncology Original original-article Phenotypic plasticity Proteomics Proto-Oncogene Protein c-fli-1 - biosynthesis Proto-Oncogene Protein c-fli-1 - genetics RNA-Binding Protein EWS RNA-Binding Proteins - biosynthesis RNA-Binding Proteins - genetics Sarcoma, Ewing - genetics Sarcoma, Ewing - metabolism Sarcoma, Ewing - pathology Transcription factors Tumors Zebrafish
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