Prenatal Vitamin D Intake, Cord Blood 25-Hydroxyvitamin D, and Offspring Body Composition: The Healthy Start Study
Vitamin D deficiency in pregnancy may be associated with increased offspring adiposity, but evidence from human studies is inconclusive. We examined associations between prenatal vitamin D intake, 25-hydroxyvitamin D (25(OH)D) in cord blood, and offspring size and body composition at birth and 5 mon...
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description | Vitamin D deficiency in pregnancy may be associated with increased offspring adiposity, but evidence from human studies is inconclusive. We examined associations between prenatal vitamin D intake, 25-hydroxyvitamin D (25(OH)D) in cord blood, and offspring size and body composition at birth and 5 months. Participants included 605 mother-offspring dyads from the Healthy Start study, an ongoing, pre-birth prospective cohort study in Denver, Colorado, USA. Prenatal vitamin D intake was assessed with diet recalls and questionnaires, and offspring body composition was measured via air displacement plethysmography at birth and 5 months. General linear univariate models were used for analysis, adjusting for maternal age, race/ethnicity, pre-pregnancy body mass index (BMI), offspring sex, and gestational age at birth. Non-Hispanic white race, lower pre-pregnancy BMI, higher prenatal vitamin D intake, and summer births were associated with higher cord blood 25(OH)D. Higher 25(OH)D was associated with lower birthweight (
= -6.22,
= 0.02), but as maternal BMI increased, this association became increasingly positive in direction and magnitude (
= 1.05,
= 0.04). Higher 25(OH)D was also associated with lower neonatal adiposity (β = -0.02, p < 0.05) but not after adjustment for maternal BMI (
= -0.01,
= 0.25). Cord blood 25(OH)D was not associated with offspring size or body composition at 5 months. Our data confirm the hypothesis that vitamin D exposure in early life is associated with neonatal body size and composition. Future research is needed to understand the implications of these associations as infants grow. |
doi_str_mv | 10.3390/nu9070790 |
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= -6.22,
= 0.02), but as maternal BMI increased, this association became increasingly positive in direction and magnitude (
= 1.05,
= 0.04). Higher 25(OH)D was also associated with lower neonatal adiposity (β = -0.02, p < 0.05) but not after adjustment for maternal BMI (
= -0.01,
= 0.25). Cord blood 25(OH)D was not associated with offspring size or body composition at 5 months. Our data confirm the hypothesis that vitamin D exposure in early life is associated with neonatal body size and composition. Future research is needed to understand the implications of these associations as infants grow.</description><identifier>ISSN: 2072-6643</identifier><identifier>EISSN: 2072-6643</identifier><identifier>DOI: 10.3390/nu9070790</identifier><identifier>PMID: 28737667</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>25-Hydroxyvitamin D ; Adipose tissue ; Adiposity ; Birth ; Birth weight ; Blood ; Body Composition ; Body mass ; Body Mass Index ; Body size ; Childbirth & labor ; cohort studies ; Colorado ; Cord blood ; densitometry ; Diet ; Female ; Fetal Blood - chemistry ; Gestational Age ; Humans ; Infant ; Infant, Newborn ; Infants ; Male ; Maternal Nutritional Physiological Phenomena ; Mental Recall ; Minority & ethnic groups ; nationalities and ethnic groups ; Neonates ; Nutrient deficiency ; Offspring ; Pediatric Obesity - blood ; Pediatric Obesity - prevention & control ; Plethysmography ; Pregnancy ; Premature birth ; Prenatal Care ; progeny ; Prospective Studies ; questionnaires ; summer ; Surveys and Questionnaires ; Vitamin D ; Vitamin D - administration & dosage ; Vitamin D - blood ; vitamin D deficiency ; Vitamin deficiency</subject><ispartof>Nutrients, 2017-07, Vol.9 (7), p.790</ispartof><rights>2017. This work is licensed under https://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2017 by the authors. 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c436t-d429dcbe52bb62c7258816ef4a0bbcedef1b51e2f3f5c4c84e4870d162a5cc293</citedby><cites>FETCH-LOGICAL-c436t-d429dcbe52bb62c7258816ef4a0bbcedef1b51e2f3f5c4c84e4870d162a5cc293</cites><orcidid>0000-0002-2665-9124</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5537904/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5537904/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,725,778,782,883,27911,27912,53778,53780</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28737667$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sauder, Katherine A</creatorcontrib><creatorcontrib>Koeppen, Hallie J</creatorcontrib><creatorcontrib>Shapiro, Allison L B</creatorcontrib><creatorcontrib>Kalata, Kathryn E</creatorcontrib><creatorcontrib>Stamatoiu, Alexandra V</creatorcontrib><creatorcontrib>Ringham, Brandy M</creatorcontrib><creatorcontrib>Glueck, Deborah H</creatorcontrib><creatorcontrib>Norris, Jill M</creatorcontrib><creatorcontrib>Dabelea, Dana</creatorcontrib><title>Prenatal Vitamin D Intake, Cord Blood 25-Hydroxyvitamin D, and Offspring Body Composition: The Healthy Start Study</title><title>Nutrients</title><addtitle>Nutrients</addtitle><description>Vitamin D deficiency in pregnancy may be associated with increased offspring adiposity, but evidence from human studies is inconclusive. We examined associations between prenatal vitamin D intake, 25-hydroxyvitamin D (25(OH)D) in cord blood, and offspring size and body composition at birth and 5 months. Participants included 605 mother-offspring dyads from the Healthy Start study, an ongoing, pre-birth prospective cohort study in Denver, Colorado, USA. Prenatal vitamin D intake was assessed with diet recalls and questionnaires, and offspring body composition was measured via air displacement plethysmography at birth and 5 months. General linear univariate models were used for analysis, adjusting for maternal age, race/ethnicity, pre-pregnancy body mass index (BMI), offspring sex, and gestational age at birth. Non-Hispanic white race, lower pre-pregnancy BMI, higher prenatal vitamin D intake, and summer births were associated with higher cord blood 25(OH)D. Higher 25(OH)D was associated with lower birthweight (
= -6.22,
= 0.02), but as maternal BMI increased, this association became increasingly positive in direction and magnitude (
= 1.05,
= 0.04). Higher 25(OH)D was also associated with lower neonatal adiposity (β = -0.02, p < 0.05) but not after adjustment for maternal BMI (
= -0.01,
= 0.25). Cord blood 25(OH)D was not associated with offspring size or body composition at 5 months. Our data confirm the hypothesis that vitamin D exposure in early life is associated with neonatal body size and composition. Future research is needed to understand the implications of these associations as infants grow.</description><subject>25-Hydroxyvitamin D</subject><subject>Adipose tissue</subject><subject>Adiposity</subject><subject>Birth</subject><subject>Birth weight</subject><subject>Blood</subject><subject>Body Composition</subject><subject>Body mass</subject><subject>Body Mass Index</subject><subject>Body size</subject><subject>Childbirth & labor</subject><subject>cohort studies</subject><subject>Colorado</subject><subject>Cord blood</subject><subject>densitometry</subject><subject>Diet</subject><subject>Female</subject><subject>Fetal Blood - chemistry</subject><subject>Gestational Age</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Infants</subject><subject>Male</subject><subject>Maternal Nutritional Physiological Phenomena</subject><subject>Mental Recall</subject><subject>Minority & ethnic groups</subject><subject>nationalities and ethnic groups</subject><subject>Neonates</subject><subject>Nutrient deficiency</subject><subject>Offspring</subject><subject>Pediatric Obesity - blood</subject><subject>Pediatric Obesity - prevention & control</subject><subject>Plethysmography</subject><subject>Pregnancy</subject><subject>Premature birth</subject><subject>Prenatal Care</subject><subject>progeny</subject><subject>Prospective Studies</subject><subject>questionnaires</subject><subject>summer</subject><subject>Surveys and Questionnaires</subject><subject>Vitamin D</subject><subject>Vitamin D - administration & dosage</subject><subject>Vitamin D - blood</subject><subject>vitamin D deficiency</subject><subject>Vitamin deficiency</subject><issn>2072-6643</issn><issn>2072-6643</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNqFkU1rFTEYhYMottQu_AMScKPQ0XxMkhkXgr1-3EKhgtVtyCTv9E6dSa5Jpjj_3lzaXqobs0heyJPDyTkIPafkDecteevnliiiWvIIHTKiWCVlzR8_mA_QcUrXZLcKJ_lTdMAaxZWU6hDFrxG8yWbEP4ZspsHjj_jMZ_MTTvAqRIdPxxAcZqJaLy6G38vNPXaCjXf4ou_TNg7-Cp8Gt5Qn0zakIQ_Bv8OXG8BrMGPeLPhbNjGXfXbLM_SkN2OC47vzCH3__Olyta7OL76crT6cV7bmMleuZq2zHQjWdZJZxUTTUAl9bUjXWXDQ005QYD3vha1tU0PdKOKoZEZYy1p-hN7f6m7nbgJnwedoRl3cTiYuOphB_33jh42-CjdaCF7irIvAqzuBGH7NkLKehmRhHI2HMCfNmKLFkiyZ_g-lLeOUMqF2qi__Qa_DHH1JQjNKGqEkZbxQr28pG0NKEfq9b0r0rne9772wLx5-dE_et8z_ACSqqAA</recordid><startdate>20170722</startdate><enddate>20170722</enddate><creator>Sauder, Katherine A</creator><creator>Koeppen, Hallie J</creator><creator>Shapiro, Allison L B</creator><creator>Kalata, Kathryn E</creator><creator>Stamatoiu, Alexandra V</creator><creator>Ringham, Brandy M</creator><creator>Glueck, Deborah H</creator><creator>Norris, Jill M</creator><creator>Dabelea, Dana</creator><general>MDPI AG</general><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TS</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>7S9</scope><scope>L.6</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-2665-9124</orcidid></search><sort><creationdate>20170722</creationdate><title>Prenatal Vitamin D Intake, Cord Blood 25-Hydroxyvitamin D, and Offspring Body Composition: The Healthy Start Study</title><author>Sauder, Katherine A ; Koeppen, Hallie J ; Shapiro, Allison L B ; Kalata, Kathryn E ; Stamatoiu, Alexandra V ; Ringham, Brandy M ; Glueck, Deborah H ; Norris, Jill M ; Dabelea, Dana</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c436t-d429dcbe52bb62c7258816ef4a0bbcedef1b51e2f3f5c4c84e4870d162a5cc293</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>25-Hydroxyvitamin D</topic><topic>Adipose tissue</topic><topic>Adiposity</topic><topic>Birth</topic><topic>Birth weight</topic><topic>Blood</topic><topic>Body Composition</topic><topic>Body mass</topic><topic>Body Mass Index</topic><topic>Body size</topic><topic>Childbirth & labor</topic><topic>cohort studies</topic><topic>Colorado</topic><topic>Cord blood</topic><topic>densitometry</topic><topic>Diet</topic><topic>Female</topic><topic>Fetal Blood - chemistry</topic><topic>Gestational Age</topic><topic>Humans</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Infants</topic><topic>Male</topic><topic>Maternal Nutritional Physiological Phenomena</topic><topic>Mental Recall</topic><topic>Minority & ethnic groups</topic><topic>nationalities and ethnic groups</topic><topic>Neonates</topic><topic>Nutrient deficiency</topic><topic>Offspring</topic><topic>Pediatric Obesity - blood</topic><topic>Pediatric Obesity - prevention & control</topic><topic>Plethysmography</topic><topic>Pregnancy</topic><topic>Premature birth</topic><topic>Prenatal Care</topic><topic>progeny</topic><topic>Prospective Studies</topic><topic>questionnaires</topic><topic>summer</topic><topic>Surveys and Questionnaires</topic><topic>Vitamin D</topic><topic>Vitamin D - administration & dosage</topic><topic>Vitamin D - blood</topic><topic>vitamin D deficiency</topic><topic>Vitamin deficiency</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sauder, Katherine A</creatorcontrib><creatorcontrib>Koeppen, Hallie J</creatorcontrib><creatorcontrib>Shapiro, Allison L B</creatorcontrib><creatorcontrib>Kalata, Kathryn E</creatorcontrib><creatorcontrib>Stamatoiu, Alexandra V</creatorcontrib><creatorcontrib>Ringham, Brandy M</creatorcontrib><creatorcontrib>Glueck, Deborah H</creatorcontrib><creatorcontrib>Norris, Jill M</creatorcontrib><creatorcontrib>Dabelea, Dana</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Physical Education Index</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Nutrients</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sauder, Katherine A</au><au>Koeppen, Hallie J</au><au>Shapiro, Allison L B</au><au>Kalata, Kathryn E</au><au>Stamatoiu, Alexandra V</au><au>Ringham, Brandy M</au><au>Glueck, Deborah H</au><au>Norris, Jill M</au><au>Dabelea, Dana</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prenatal Vitamin D Intake, Cord Blood 25-Hydroxyvitamin D, and Offspring Body Composition: The Healthy Start Study</atitle><jtitle>Nutrients</jtitle><addtitle>Nutrients</addtitle><date>2017-07-22</date><risdate>2017</risdate><volume>9</volume><issue>7</issue><spage>790</spage><pages>790-</pages><issn>2072-6643</issn><eissn>2072-6643</eissn><abstract>Vitamin D deficiency in pregnancy may be associated with increased offspring adiposity, but evidence from human studies is inconclusive. We examined associations between prenatal vitamin D intake, 25-hydroxyvitamin D (25(OH)D) in cord blood, and offspring size and body composition at birth and 5 months. Participants included 605 mother-offspring dyads from the Healthy Start study, an ongoing, pre-birth prospective cohort study in Denver, Colorado, USA. Prenatal vitamin D intake was assessed with diet recalls and questionnaires, and offspring body composition was measured via air displacement plethysmography at birth and 5 months. General linear univariate models were used for analysis, adjusting for maternal age, race/ethnicity, pre-pregnancy body mass index (BMI), offspring sex, and gestational age at birth. Non-Hispanic white race, lower pre-pregnancy BMI, higher prenatal vitamin D intake, and summer births were associated with higher cord blood 25(OH)D. Higher 25(OH)D was associated with lower birthweight (
= -6.22,
= 0.02), but as maternal BMI increased, this association became increasingly positive in direction and magnitude (
= 1.05,
= 0.04). Higher 25(OH)D was also associated with lower neonatal adiposity (β = -0.02, p < 0.05) but not after adjustment for maternal BMI (
= -0.01,
= 0.25). Cord blood 25(OH)D was not associated with offspring size or body composition at 5 months. Our data confirm the hypothesis that vitamin D exposure in early life is associated with neonatal body size and composition. Future research is needed to understand the implications of these associations as infants grow.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>28737667</pmid><doi>10.3390/nu9070790</doi><orcidid>https://orcid.org/0000-0002-2665-9124</orcidid><oa>free_for_read</oa></addata></record> |
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subjects | 25-Hydroxyvitamin D Adipose tissue Adiposity Birth Birth weight Blood Body Composition Body mass Body Mass Index Body size Childbirth & labor cohort studies Colorado Cord blood densitometry Diet Female Fetal Blood - chemistry Gestational Age Humans Infant Infant, Newborn Infants Male Maternal Nutritional Physiological Phenomena Mental Recall Minority & ethnic groups nationalities and ethnic groups Neonates Nutrient deficiency Offspring Pediatric Obesity - blood Pediatric Obesity - prevention & control Plethysmography Pregnancy Premature birth Prenatal Care progeny Prospective Studies questionnaires summer Surveys and Questionnaires Vitamin D Vitamin D - administration & dosage Vitamin D - blood vitamin D deficiency Vitamin deficiency |
title | Prenatal Vitamin D Intake, Cord Blood 25-Hydroxyvitamin D, and Offspring Body Composition: The Healthy Start Study |
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