Alterations in Circulating Amino Acid Metabolite Ratio Associated with Arginase Activity Are Potential Indicators of Metabolic Syndrome: The Korean Genome and Epidemiology Study
Upregulated arginase activity, which competes with nitric oxide synthase (NOS), impairs nitric oxide production and has been implicated in various metabolic disorders. This study examined whether circulating amino acid metabolite ratios are associated with arginase and NOS activities and whether arg...
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| Veröffentlicht in: | Nutrients 2017-07, Vol.9 (7), p.740 |
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| creator | Moon, Jiyoung Kim, Oh Yoen Jo, Garam Shin, Min-Jeong |
| description | Upregulated arginase activity, which competes with nitric oxide synthase (NOS), impairs nitric oxide production and has been implicated in various metabolic disorders. This study examined whether circulating amino acid metabolite ratios are associated with arginase and NOS activities and whether arginine bioavailability is associated with metabolic syndrome (MetS). Data related to arginase and NOS activities were collected from non-diabetic Koreans without cardiovascular disease (
= 1998) in the Ansan-Ansung cohorts (2005-2006). Subsequently, correlation and multivariate logistic regression analyses were performed. With the increase in the number of MetS risk factors, ratios of circulating amino acid metabolites, such as those of ornithine/citrulline, proline/citrulline, and ornithine/arginine, also significantly increased, whereas arginine bioavailability significantly decreased. These metabolite ratios and arginase bioavailability were also significantly correlated with MetS risk-related parameters, which remained significant after adjusting for covariates. In addition, logistic regression analysis revealed that high ratios of circulating metabolites and low arginine bioavailability, which indicated increased arginase activity, were significantly associated with a high MetS risk. This study demonstrated that altered ratios of circulating amino acid metabolites indicates increased arginase activity and decreased arginine bioavailability, both of which can be potential markers for MetS risk. |
| doi_str_mv | 10.3390/nu9070740 |
| format | Article |
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= 1998) in the Ansan-Ansung cohorts (2005-2006). Subsequently, correlation and multivariate logistic regression analyses were performed. With the increase in the number of MetS risk factors, ratios of circulating amino acid metabolites, such as those of ornithine/citrulline, proline/citrulline, and ornithine/arginine, also significantly increased, whereas arginine bioavailability significantly decreased. These metabolite ratios and arginase bioavailability were also significantly correlated with MetS risk-related parameters, which remained significant after adjusting for covariates. In addition, logistic regression analysis revealed that high ratios of circulating metabolites and low arginine bioavailability, which indicated increased arginase activity, were significantly associated with a high MetS risk. This study demonstrated that altered ratios of circulating amino acid metabolites indicates increased arginase activity and decreased arginine bioavailability, both of which can be potential markers for MetS risk.</description><identifier>ISSN: 2072-6643</identifier><identifier>EISSN: 2072-6643</identifier><identifier>DOI: 10.3390/nu9070740</identifier><identifier>PMID: 28704931</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Acids ; Adult ; Aged ; Alanine Transaminase - blood ; Amino acids ; Amino Acids - blood ; Arginase ; Arginase - metabolism ; Arginine ; Arginine - blood ; Asian People - genetics ; Aspartate Aminotransferases - blood ; Bioavailability ; Cardiovascular diseases ; Cholesterol - blood ; Citrulline ; Citrulline - blood ; Correlation analysis ; Cross-Sectional Studies ; Diabetes mellitus ; enzyme activity ; Epidemiologic Studies ; Epidemiology ; Female ; Follow-Up Studies ; genome ; Genomes ; Humans ; Koreans ; Life Style ; Male ; metabolic diseases ; Metabolic disorders ; Metabolic syndrome ; Metabolic Syndrome - blood ; Metabolic Syndrome - epidemiology ; Metabolic Syndrome - genetics ; Metabolites ; Middle Aged ; Nitric oxide ; Nitric-oxide synthase ; Ornithine ; Ornithine - blood ; Proline ; Proline - blood ; Prospective Studies ; Regression analysis ; Republic of Korea - epidemiology ; Risk analysis ; Risk Factors ; Surveys and Questionnaires ; Triglycerides - blood</subject><ispartof>Nutrients, 2017-07, Vol.9 (7), p.740</ispartof><rights>2017. This work is licensed under https://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2017 by the authors. 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c436t-45adacfe9cdbe23cd40000aa09d1f54dbc521871b5a49edeab5155bf3b2eade53</citedby><cites>FETCH-LOGICAL-c436t-45adacfe9cdbe23cd40000aa09d1f54dbc521871b5a49edeab5155bf3b2eade53</cites><orcidid>0000-0001-9262-3309</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5537854/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5537854/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27903,27904,53769,53771</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28704931$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Moon, Jiyoung</creatorcontrib><creatorcontrib>Kim, Oh Yoen</creatorcontrib><creatorcontrib>Jo, Garam</creatorcontrib><creatorcontrib>Shin, Min-Jeong</creatorcontrib><title>Alterations in Circulating Amino Acid Metabolite Ratio Associated with Arginase Activity Are Potential Indicators of Metabolic Syndrome: The Korean Genome and Epidemiology Study</title><title>Nutrients</title><addtitle>Nutrients</addtitle><description>Upregulated arginase activity, which competes with nitric oxide synthase (NOS), impairs nitric oxide production and has been implicated in various metabolic disorders. This study examined whether circulating amino acid metabolite ratios are associated with arginase and NOS activities and whether arginine bioavailability is associated with metabolic syndrome (MetS). Data related to arginase and NOS activities were collected from non-diabetic Koreans without cardiovascular disease (
= 1998) in the Ansan-Ansung cohorts (2005-2006). Subsequently, correlation and multivariate logistic regression analyses were performed. With the increase in the number of MetS risk factors, ratios of circulating amino acid metabolites, such as those of ornithine/citrulline, proline/citrulline, and ornithine/arginine, also significantly increased, whereas arginine bioavailability significantly decreased. These metabolite ratios and arginase bioavailability were also significantly correlated with MetS risk-related parameters, which remained significant after adjusting for covariates. In addition, logistic regression analysis revealed that high ratios of circulating metabolites and low arginine bioavailability, which indicated increased arginase activity, were significantly associated with a high MetS risk. This study demonstrated that altered ratios of circulating amino acid metabolites indicates increased arginase activity and decreased arginine bioavailability, both of which can be potential markers for MetS risk.</description><subject>Acids</subject><subject>Adult</subject><subject>Aged</subject><subject>Alanine Transaminase - blood</subject><subject>Amino acids</subject><subject>Amino Acids - blood</subject><subject>Arginase</subject><subject>Arginase - metabolism</subject><subject>Arginine</subject><subject>Arginine - blood</subject><subject>Asian People - genetics</subject><subject>Aspartate Aminotransferases - blood</subject><subject>Bioavailability</subject><subject>Cardiovascular diseases</subject><subject>Cholesterol - blood</subject><subject>Citrulline</subject><subject>Citrulline - blood</subject><subject>Correlation analysis</subject><subject>Cross-Sectional Studies</subject><subject>Diabetes mellitus</subject><subject>enzyme activity</subject><subject>Epidemiologic Studies</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>genome</subject><subject>Genomes</subject><subject>Humans</subject><subject>Koreans</subject><subject>Life Style</subject><subject>Male</subject><subject>metabolic diseases</subject><subject>Metabolic disorders</subject><subject>Metabolic syndrome</subject><subject>Metabolic Syndrome - blood</subject><subject>Metabolic Syndrome - epidemiology</subject><subject>Metabolic Syndrome - genetics</subject><subject>Metabolites</subject><subject>Middle Aged</subject><subject>Nitric oxide</subject><subject>Nitric-oxide synthase</subject><subject>Ornithine</subject><subject>Ornithine - blood</subject><subject>Proline</subject><subject>Proline - blood</subject><subject>Prospective Studies</subject><subject>Regression analysis</subject><subject>Republic of Korea - epidemiology</subject><subject>Risk analysis</subject><subject>Risk Factors</subject><subject>Surveys and Questionnaires</subject><subject>Triglycerides - blood</subject><issn>2072-6643</issn><issn>2072-6643</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqFkk1v1DAQhiMEolXpgT-ALHGBw4I_88EBKVqVUlEEouUcTezJrqvEXmynKD-Lf4hXLavCBV_Gnnn0emb0FsVzRt8I0dC3bm5oRStJHxXHnFZ8VZZSPH5wPypOY7yh-5O5UjwtjnhdUdkIdlz8aseEAZL1LhLryNoGPY_57TaknazzpNXWkM-YoPejTUi-7WHSxui1hYSG_LRpS9qwsQ4iZjzZW5uWnEHy1Sd0ycJILpyxGpIPkfjhIKfJ1eJM8BO-I9dbJJ98QHDkHF1OEXCGnO2swcn60W8WcpVmszwrngwwRjy9jyfF9w9n1-uPq8sv5xfr9nKlpSjTSiowoAdstOmRC23kfgEAtDFsUNL0WnFWV6xXIBs0CL1iSvWD6DmCQSVOivd3uru5n9DoPEiAsdsFO0FYOg-2-7vi7Lbb-NtOKVHVSmaBV_cCwf-YMaZuslHjOIJDP8eO87psJJdl9V-UNZxymtutM_ryH_TGz8HlTXSc0VpVDZP7v1_fUTr4GAMOh74Z7fa26Q62yeyLh4MeyD8mEb8Bp9bBWg</recordid><startdate>20170712</startdate><enddate>20170712</enddate><creator>Moon, Jiyoung</creator><creator>Kim, Oh Yoen</creator><creator>Jo, Garam</creator><creator>Shin, Min-Jeong</creator><general>MDPI AG</general><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TS</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>7S9</scope><scope>L.6</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-9262-3309</orcidid></search><sort><creationdate>20170712</creationdate><title>Alterations in Circulating Amino Acid Metabolite Ratio Associated with Arginase Activity Are Potential Indicators of Metabolic Syndrome: The Korean Genome and Epidemiology Study</title><author>Moon, Jiyoung ; Kim, Oh Yoen ; Jo, Garam ; Shin, Min-Jeong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c436t-45adacfe9cdbe23cd40000aa09d1f54dbc521871b5a49edeab5155bf3b2eade53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Acids</topic><topic>Adult</topic><topic>Aged</topic><topic>Alanine Transaminase - blood</topic><topic>Amino acids</topic><topic>Amino Acids - blood</topic><topic>Arginase</topic><topic>Arginase - metabolism</topic><topic>Arginine</topic><topic>Arginine - blood</topic><topic>Asian People - genetics</topic><topic>Aspartate Aminotransferases - blood</topic><topic>Bioavailability</topic><topic>Cardiovascular diseases</topic><topic>Cholesterol - blood</topic><topic>Citrulline</topic><topic>Citrulline - blood</topic><topic>Correlation analysis</topic><topic>Cross-Sectional Studies</topic><topic>Diabetes mellitus</topic><topic>enzyme activity</topic><topic>Epidemiologic Studies</topic><topic>Epidemiology</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>genome</topic><topic>Genomes</topic><topic>Humans</topic><topic>Koreans</topic><topic>Life Style</topic><topic>Male</topic><topic>metabolic diseases</topic><topic>Metabolic disorders</topic><topic>Metabolic syndrome</topic><topic>Metabolic Syndrome - blood</topic><topic>Metabolic Syndrome - epidemiology</topic><topic>Metabolic Syndrome - genetics</topic><topic>Metabolites</topic><topic>Middle Aged</topic><topic>Nitric oxide</topic><topic>Nitric-oxide synthase</topic><topic>Ornithine</topic><topic>Ornithine - blood</topic><topic>Proline</topic><topic>Proline - blood</topic><topic>Prospective Studies</topic><topic>Regression analysis</topic><topic>Republic of Korea - epidemiology</topic><topic>Risk analysis</topic><topic>Risk Factors</topic><topic>Surveys and Questionnaires</topic><topic>Triglycerides - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Moon, Jiyoung</creatorcontrib><creatorcontrib>Kim, Oh Yoen</creatorcontrib><creatorcontrib>Jo, Garam</creatorcontrib><creatorcontrib>Shin, Min-Jeong</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Physical Education Index</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Nutrients</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Moon, Jiyoung</au><au>Kim, Oh Yoen</au><au>Jo, Garam</au><au>Shin, Min-Jeong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Alterations in Circulating Amino Acid Metabolite Ratio Associated with Arginase Activity Are Potential Indicators of Metabolic Syndrome: The Korean Genome and Epidemiology Study</atitle><jtitle>Nutrients</jtitle><addtitle>Nutrients</addtitle><date>2017-07-12</date><risdate>2017</risdate><volume>9</volume><issue>7</issue><spage>740</spage><pages>740-</pages><issn>2072-6643</issn><eissn>2072-6643</eissn><abstract>Upregulated arginase activity, which competes with nitric oxide synthase (NOS), impairs nitric oxide production and has been implicated in various metabolic disorders. This study examined whether circulating amino acid metabolite ratios are associated with arginase and NOS activities and whether arginine bioavailability is associated with metabolic syndrome (MetS). Data related to arginase and NOS activities were collected from non-diabetic Koreans without cardiovascular disease (
= 1998) in the Ansan-Ansung cohorts (2005-2006). Subsequently, correlation and multivariate logistic regression analyses were performed. With the increase in the number of MetS risk factors, ratios of circulating amino acid metabolites, such as those of ornithine/citrulline, proline/citrulline, and ornithine/arginine, also significantly increased, whereas arginine bioavailability significantly decreased. These metabolite ratios and arginase bioavailability were also significantly correlated with MetS risk-related parameters, which remained significant after adjusting for covariates. In addition, logistic regression analysis revealed that high ratios of circulating metabolites and low arginine bioavailability, which indicated increased arginase activity, were significantly associated with a high MetS risk. This study demonstrated that altered ratios of circulating amino acid metabolites indicates increased arginase activity and decreased arginine bioavailability, both of which can be potential markers for MetS risk.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>28704931</pmid><doi>10.3390/nu9070740</doi><orcidid>https://orcid.org/0000-0001-9262-3309</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Acids Adult Aged Alanine Transaminase - blood Amino acids Amino Acids - blood Arginase Arginase - metabolism Arginine Arginine - blood Asian People - genetics Aspartate Aminotransferases - blood Bioavailability Cardiovascular diseases Cholesterol - blood Citrulline Citrulline - blood Correlation analysis Cross-Sectional Studies Diabetes mellitus enzyme activity Epidemiologic Studies Epidemiology Female Follow-Up Studies genome Genomes Humans Koreans Life Style Male metabolic diseases Metabolic disorders Metabolic syndrome Metabolic Syndrome - blood Metabolic Syndrome - epidemiology Metabolic Syndrome - genetics Metabolites Middle Aged Nitric oxide Nitric-oxide synthase Ornithine Ornithine - blood Proline Proline - blood Prospective Studies Regression analysis Republic of Korea - epidemiology Risk analysis Risk Factors Surveys and Questionnaires Triglycerides - blood |
| title | Alterations in Circulating Amino Acid Metabolite Ratio Associated with Arginase Activity Are Potential Indicators of Metabolic Syndrome: The Korean Genome and Epidemiology Study |
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