Chlorogenic Acid Ameliorates Experimental Colitis by Promoting Growth of Akkermansia in Mice
Chlorogenic acid (ChA)-one of the most abundant polyphenol compounds in the human diet-exerts anti-inflammatory activities. The aim of this study was to investigate the effect of ChA on gut microbiota in ulcerative colitis (UC). Colitis was induced by 2.5% dextran sulfate sodium (DSS) in C57BL/6 mic...
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| Veröffentlicht in: | Nutrients 2017-06, Vol.9 (7), p.677 |
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| creator | Zhang, Zhan Wu, Xinyue Cao, Shuyuan Cromie, Meghan Shen, Yonghua Feng, Yiming Yang, Hui Li, Lei |
| description | Chlorogenic acid (ChA)-one of the most abundant polyphenol compounds in the human diet-exerts anti-inflammatory activities. The aim of this study was to investigate the effect of ChA on gut microbiota in ulcerative colitis (UC). Colitis was induced by 2.5% dextran sulfate sodium (DSS) in C57BL/6 mice, which were on a control diet or diet with ChA (1 mM). The histopathological changes and inflammation were evaluated. Fecal samples were analyzed by 16S rRNA gene sequencing. ChA attenuated several effects of DSS-induced colitis, including weight loss, increased disease activity index, and improved mucosal damage. Moreover, ChA could significantly suppress the secretion of IFNγ, TNFα, and IL-6 and the colonic infiltration of F4/80⁺ macrophages, CD3⁺ T cells, and CD177⁺ neutrophils via inhibition of the active NF-κB signaling pathway. In addition, ChA decreased the proportion of
and
. ChA also enhanced a reduction in fecal microbiota diversity in DSS treated mice. Interestingly, ChA treatment markedly increased the proportion of the mucin-degrading bacterium
in colitis mice. ChA acted as the intestine-modifying gut microbial community structure, resulting in a lower intestinal and systemic inflammation and also improving the course of the DSS-induced colitis, which is associated with a proportional increase in
. |
| doi_str_mv | 10.3390/nu9070677 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5537792</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1914848003</sourcerecordid><originalsourceid>FETCH-LOGICAL-c502t-90e60a7028599b0788325fc63078c184230fba9031d48235f533b360a89f05543</originalsourceid><addsrcrecordid>eNqFkU9rVDEUxYMottQu_AIScKOL0Zv_yUYYhlqFFruoOyHkZfJm0r6XjMl71X57U9oO1Y3Z5MD95XBuDkKvCXxgzMDHNBtQIJV6hg4pKLqQkrPnT_QBOq71Cu6OAiXZS3RAtZSEC36Ifqy2Qy55E1L0eOnjGi_HMMRc3BQqPvm9CyWOIU1uwKs8xClW3N3ii5LHPMW0wacl_5q2OPd4eX0dyuhSjQ7HhM-jD6_Qi94NNRw_3Efo--eTy9WXxdm306-r5dnCC6DTwkCQ4BRQLYzpQGnNqOi9ZE16ojll0HfOACNrrikTvWCsY-2JNj0IwdkR-nTvu5u7Max9y1vcYHctuiu3Nrto_56kuLWbfGOFYEoZ2gzePRiU_HMOdbJjrD4Mg0shz9VSqogGrg3_L0oM4ZprANbQt_-gV3kuqf2EpQS0UJIw0aj395QvudYS-n1uAvauYbtvuLFvni66Jx_7ZH8Am1Sewg</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2108576135</pqid></control><display><type>article</type><title>Chlorogenic Acid Ameliorates Experimental Colitis by Promoting Growth of Akkermansia in Mice</title><source>MDPI - Multidisciplinary Digital Publishing Institute</source><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><source>PubMed Central Open Access</source><creator>Zhang, Zhan ; Wu, Xinyue ; Cao, Shuyuan ; Cromie, Meghan ; Shen, Yonghua ; Feng, Yiming ; Yang, Hui ; Li, Lei</creator><creatorcontrib>Zhang, Zhan ; Wu, Xinyue ; Cao, Shuyuan ; Cromie, Meghan ; Shen, Yonghua ; Feng, Yiming ; Yang, Hui ; Li, Lei</creatorcontrib><description>Chlorogenic acid (ChA)-one of the most abundant polyphenol compounds in the human diet-exerts anti-inflammatory activities. The aim of this study was to investigate the effect of ChA on gut microbiota in ulcerative colitis (UC). Colitis was induced by 2.5% dextran sulfate sodium (DSS) in C57BL/6 mice, which were on a control diet or diet with ChA (1 mM). The histopathological changes and inflammation were evaluated. Fecal samples were analyzed by 16S rRNA gene sequencing. ChA attenuated several effects of DSS-induced colitis, including weight loss, increased disease activity index, and improved mucosal damage. Moreover, ChA could significantly suppress the secretion of IFNγ, TNFα, and IL-6 and the colonic infiltration of F4/80⁺ macrophages, CD3⁺ T cells, and CD177⁺ neutrophils via inhibition of the active NF-κB signaling pathway. In addition, ChA decreased the proportion of
and
. ChA also enhanced a reduction in fecal microbiota diversity in DSS treated mice. Interestingly, ChA treatment markedly increased the proportion of the mucin-degrading bacterium
in colitis mice. ChA acted as the intestine-modifying gut microbial community structure, resulting in a lower intestinal and systemic inflammation and also improving the course of the DSS-induced colitis, which is associated with a proportional increase in
.</description><identifier>ISSN: 2072-6643</identifier><identifier>EISSN: 2072-6643</identifier><identifier>DOI: 10.3390/nu9070677</identifier><identifier>PMID: 28661454</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Animals ; anti-inflammatory activity ; bacteria ; Bacteroidetes ; Body weight loss ; CD3 antigen ; Chlorogenic acid ; Chlorogenic Acid - pharmacology ; colitis ; Colitis - chemically induced ; Colitis - drug therapy ; Colon ; Colon - pathology ; Community structure ; Dextran ; Dextran sulfate ; Dextran Sulfate - toxicity ; diet ; Digestive system ; Fecal microflora ; feces ; Feces - microbiology ; Female ; Firmicutes ; histopathology ; humans ; inflammation ; Inflammatory bowel disease ; Inflammatory bowel diseases ; Interleukin 6 ; Intestinal microflora ; intestinal microorganisms ; Intestine ; intestines ; Leukocytes (neutrophilic) ; Lymphocytes ; Lymphocytes T ; Macrophages ; Mice ; Mice, Inbred C57BL ; microbial communities ; Microbiota ; Microorganisms ; Mucin ; Mucosa ; neutrophils ; NF-κB protein ; polyphenols ; Random Allocation ; ribosomal RNA ; Rodents ; rRNA 16S ; secretion ; sequence analysis ; Signal transduction ; Sodium ; T-lymphocytes ; transcription factor NF-kappa B ; tumor necrosis factor-alpha ; Tumor necrosis factor-α ; Ulcerative colitis ; Verrucomicrobia - drug effects ; Verrucomicrobia - growth & development ; Weight loss ; γ-Interferon</subject><ispartof>Nutrients, 2017-06, Vol.9 (7), p.677</ispartof><rights>2017. This work is licensed under https://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2017 by the authors. 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c502t-90e60a7028599b0788325fc63078c184230fba9031d48235f533b360a89f05543</citedby><cites>FETCH-LOGICAL-c502t-90e60a7028599b0788325fc63078c184230fba9031d48235f533b360a89f05543</cites><orcidid>0000-0002-9685-5753 ; 0000-0002-0014-7892</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5537792/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5537792/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27903,27904,53769,53771</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28661454$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, Zhan</creatorcontrib><creatorcontrib>Wu, Xinyue</creatorcontrib><creatorcontrib>Cao, Shuyuan</creatorcontrib><creatorcontrib>Cromie, Meghan</creatorcontrib><creatorcontrib>Shen, Yonghua</creatorcontrib><creatorcontrib>Feng, Yiming</creatorcontrib><creatorcontrib>Yang, Hui</creatorcontrib><creatorcontrib>Li, Lei</creatorcontrib><title>Chlorogenic Acid Ameliorates Experimental Colitis by Promoting Growth of Akkermansia in Mice</title><title>Nutrients</title><addtitle>Nutrients</addtitle><description>Chlorogenic acid (ChA)-one of the most abundant polyphenol compounds in the human diet-exerts anti-inflammatory activities. The aim of this study was to investigate the effect of ChA on gut microbiota in ulcerative colitis (UC). Colitis was induced by 2.5% dextran sulfate sodium (DSS) in C57BL/6 mice, which were on a control diet or diet with ChA (1 mM). The histopathological changes and inflammation were evaluated. Fecal samples were analyzed by 16S rRNA gene sequencing. ChA attenuated several effects of DSS-induced colitis, including weight loss, increased disease activity index, and improved mucosal damage. Moreover, ChA could significantly suppress the secretion of IFNγ, TNFα, and IL-6 and the colonic infiltration of F4/80⁺ macrophages, CD3⁺ T cells, and CD177⁺ neutrophils via inhibition of the active NF-κB signaling pathway. In addition, ChA decreased the proportion of
and
. ChA also enhanced a reduction in fecal microbiota diversity in DSS treated mice. Interestingly, ChA treatment markedly increased the proportion of the mucin-degrading bacterium
in colitis mice. ChA acted as the intestine-modifying gut microbial community structure, resulting in a lower intestinal and systemic inflammation and also improving the course of the DSS-induced colitis, which is associated with a proportional increase in
.</description><subject>Animals</subject><subject>anti-inflammatory activity</subject><subject>bacteria</subject><subject>Bacteroidetes</subject><subject>Body weight loss</subject><subject>CD3 antigen</subject><subject>Chlorogenic acid</subject><subject>Chlorogenic Acid - pharmacology</subject><subject>colitis</subject><subject>Colitis - chemically induced</subject><subject>Colitis - drug therapy</subject><subject>Colon</subject><subject>Colon - pathology</subject><subject>Community structure</subject><subject>Dextran</subject><subject>Dextran sulfate</subject><subject>Dextran Sulfate - toxicity</subject><subject>diet</subject><subject>Digestive system</subject><subject>Fecal microflora</subject><subject>feces</subject><subject>Feces - microbiology</subject><subject>Female</subject><subject>Firmicutes</subject><subject>histopathology</subject><subject>humans</subject><subject>inflammation</subject><subject>Inflammatory bowel disease</subject><subject>Inflammatory bowel diseases</subject><subject>Interleukin 6</subject><subject>Intestinal microflora</subject><subject>intestinal microorganisms</subject><subject>Intestine</subject><subject>intestines</subject><subject>Leukocytes (neutrophilic)</subject><subject>Lymphocytes</subject><subject>Lymphocytes T</subject><subject>Macrophages</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>microbial communities</subject><subject>Microbiota</subject><subject>Microorganisms</subject><subject>Mucin</subject><subject>Mucosa</subject><subject>neutrophils</subject><subject>NF-κB protein</subject><subject>polyphenols</subject><subject>Random Allocation</subject><subject>ribosomal RNA</subject><subject>Rodents</subject><subject>rRNA 16S</subject><subject>secretion</subject><subject>sequence analysis</subject><subject>Signal transduction</subject><subject>Sodium</subject><subject>T-lymphocytes</subject><subject>transcription factor NF-kappa B</subject><subject>tumor necrosis factor-alpha</subject><subject>Tumor necrosis factor-α</subject><subject>Ulcerative colitis</subject><subject>Verrucomicrobia - drug effects</subject><subject>Verrucomicrobia - growth & development</subject><subject>Weight loss</subject><subject>γ-Interferon</subject><issn>2072-6643</issn><issn>2072-6643</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqFkU9rVDEUxYMottQu_AIScKOL0Zv_yUYYhlqFFruoOyHkZfJm0r6XjMl71X57U9oO1Y3Z5MD95XBuDkKvCXxgzMDHNBtQIJV6hg4pKLqQkrPnT_QBOq71Cu6OAiXZS3RAtZSEC36Ifqy2Qy55E1L0eOnjGi_HMMRc3BQqPvm9CyWOIU1uwKs8xClW3N3ii5LHPMW0wacl_5q2OPd4eX0dyuhSjQ7HhM-jD6_Qi94NNRw_3Efo--eTy9WXxdm306-r5dnCC6DTwkCQ4BRQLYzpQGnNqOi9ZE16ojll0HfOACNrrikTvWCsY-2JNj0IwdkR-nTvu5u7Max9y1vcYHctuiu3Nrto_56kuLWbfGOFYEoZ2gzePRiU_HMOdbJjrD4Mg0shz9VSqogGrg3_L0oM4ZprANbQt_-gV3kuqf2EpQS0UJIw0aj395QvudYS-n1uAvauYbtvuLFvni66Jx_7ZH8Am1Sewg</recordid><startdate>20170629</startdate><enddate>20170629</enddate><creator>Zhang, Zhan</creator><creator>Wu, Xinyue</creator><creator>Cao, Shuyuan</creator><creator>Cromie, Meghan</creator><creator>Shen, Yonghua</creator><creator>Feng, Yiming</creator><creator>Yang, Hui</creator><creator>Li, Lei</creator><general>MDPI AG</general><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TS</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>7S9</scope><scope>L.6</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-9685-5753</orcidid><orcidid>https://orcid.org/0000-0002-0014-7892</orcidid></search><sort><creationdate>20170629</creationdate><title>Chlorogenic Acid Ameliorates Experimental Colitis by Promoting Growth of Akkermansia in Mice</title><author>Zhang, Zhan ; Wu, Xinyue ; Cao, Shuyuan ; Cromie, Meghan ; Shen, Yonghua ; Feng, Yiming ; Yang, Hui ; Li, Lei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c502t-90e60a7028599b0788325fc63078c184230fba9031d48235f533b360a89f05543</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Animals</topic><topic>anti-inflammatory activity</topic><topic>bacteria</topic><topic>Bacteroidetes</topic><topic>Body weight loss</topic><topic>CD3 antigen</topic><topic>Chlorogenic acid</topic><topic>Chlorogenic Acid - pharmacology</topic><topic>colitis</topic><topic>Colitis - chemically induced</topic><topic>Colitis - drug therapy</topic><topic>Colon</topic><topic>Colon - pathology</topic><topic>Community structure</topic><topic>Dextran</topic><topic>Dextran sulfate</topic><topic>Dextran Sulfate - toxicity</topic><topic>diet</topic><topic>Digestive system</topic><topic>Fecal microflora</topic><topic>feces</topic><topic>Feces - microbiology</topic><topic>Female</topic><topic>Firmicutes</topic><topic>histopathology</topic><topic>humans</topic><topic>inflammation</topic><topic>Inflammatory bowel disease</topic><topic>Inflammatory bowel diseases</topic><topic>Interleukin 6</topic><topic>Intestinal microflora</topic><topic>intestinal microorganisms</topic><topic>Intestine</topic><topic>intestines</topic><topic>Leukocytes (neutrophilic)</topic><topic>Lymphocytes</topic><topic>Lymphocytes T</topic><topic>Macrophages</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>microbial communities</topic><topic>Microbiota</topic><topic>Microorganisms</topic><topic>Mucin</topic><topic>Mucosa</topic><topic>neutrophils</topic><topic>NF-κB protein</topic><topic>polyphenols</topic><topic>Random Allocation</topic><topic>ribosomal RNA</topic><topic>Rodents</topic><topic>rRNA 16S</topic><topic>secretion</topic><topic>sequence analysis</topic><topic>Signal transduction</topic><topic>Sodium</topic><topic>T-lymphocytes</topic><topic>transcription factor NF-kappa B</topic><topic>tumor necrosis factor-alpha</topic><topic>Tumor necrosis factor-α</topic><topic>Ulcerative colitis</topic><topic>Verrucomicrobia - 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Academic</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Nutrients</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Zhan</au><au>Wu, Xinyue</au><au>Cao, Shuyuan</au><au>Cromie, Meghan</au><au>Shen, Yonghua</au><au>Feng, Yiming</au><au>Yang, Hui</au><au>Li, Lei</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Chlorogenic Acid Ameliorates Experimental Colitis by Promoting Growth of Akkermansia in Mice</atitle><jtitle>Nutrients</jtitle><addtitle>Nutrients</addtitle><date>2017-06-29</date><risdate>2017</risdate><volume>9</volume><issue>7</issue><spage>677</spage><pages>677-</pages><issn>2072-6643</issn><eissn>2072-6643</eissn><abstract>Chlorogenic acid (ChA)-one of the most abundant polyphenol compounds in the human diet-exerts anti-inflammatory activities. The aim of this study was to investigate the effect of ChA on gut microbiota in ulcerative colitis (UC). Colitis was induced by 2.5% dextran sulfate sodium (DSS) in C57BL/6 mice, which were on a control diet or diet with ChA (1 mM). The histopathological changes and inflammation were evaluated. Fecal samples were analyzed by 16S rRNA gene sequencing. ChA attenuated several effects of DSS-induced colitis, including weight loss, increased disease activity index, and improved mucosal damage. Moreover, ChA could significantly suppress the secretion of IFNγ, TNFα, and IL-6 and the colonic infiltration of F4/80⁺ macrophages, CD3⁺ T cells, and CD177⁺ neutrophils via inhibition of the active NF-κB signaling pathway. In addition, ChA decreased the proportion of
and
. ChA also enhanced a reduction in fecal microbiota diversity in DSS treated mice. Interestingly, ChA treatment markedly increased the proportion of the mucin-degrading bacterium
in colitis mice. ChA acted as the intestine-modifying gut microbial community structure, resulting in a lower intestinal and systemic inflammation and also improving the course of the DSS-induced colitis, which is associated with a proportional increase in
.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>28661454</pmid><doi>10.3390/nu9070677</doi><orcidid>https://orcid.org/0000-0002-9685-5753</orcidid><orcidid>https://orcid.org/0000-0002-0014-7892</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MDPI - Multidisciplinary Digital Publishing Institute; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; PubMed Central Open Access |
| subjects | Animals anti-inflammatory activity bacteria Bacteroidetes Body weight loss CD3 antigen Chlorogenic acid Chlorogenic Acid - pharmacology colitis Colitis - chemically induced Colitis - drug therapy Colon Colon - pathology Community structure Dextran Dextran sulfate Dextran Sulfate - toxicity diet Digestive system Fecal microflora feces Feces - microbiology Female Firmicutes histopathology humans inflammation Inflammatory bowel disease Inflammatory bowel diseases Interleukin 6 Intestinal microflora intestinal microorganisms Intestine intestines Leukocytes (neutrophilic) Lymphocytes Lymphocytes T Macrophages Mice Mice, Inbred C57BL microbial communities Microbiota Microorganisms Mucin Mucosa neutrophils NF-κB protein polyphenols Random Allocation ribosomal RNA Rodents rRNA 16S secretion sequence analysis Signal transduction Sodium T-lymphocytes transcription factor NF-kappa B tumor necrosis factor-alpha Tumor necrosis factor-α Ulcerative colitis Verrucomicrobia - drug effects Verrucomicrobia - growth & development Weight loss γ-Interferon |
| title | Chlorogenic Acid Ameliorates Experimental Colitis by Promoting Growth of Akkermansia in Mice |
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