Does Vitamin C Influence Neurodegenerative Diseases and Psychiatric Disorders?
Vitamin C (Vit C) is considered to be a vital antioxidant molecule in the brain. Intracellular Vit C helps maintain integrity and function of several processes in the central nervous system (CNS), including neuronal maturation and differentiation, myelin formation, synthesis of catecholamine, modula...
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| Veröffentlicht in: | Nutrients 2017-06, Vol.9 (7), p.659 |
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| creator | Kocot, Joanna Luchowska-Kocot, Dorota Kiełczykowska, Małgorzata Musik, Irena Kurzepa, Jacek |
| description | Vitamin C (Vit C) is considered to be a vital antioxidant molecule in the brain. Intracellular Vit C helps maintain integrity and function of several processes in the central nervous system (CNS), including neuronal maturation and differentiation, myelin formation, synthesis of catecholamine, modulation of neurotransmission and antioxidant protection. The importance of Vit C for CNS function has been proven by the fact that targeted deletion of the sodium-vitamin C co-transporter in mice results in widespread cerebral hemorrhage and death on post-natal day one. Since neurological diseases are characterized by increased free radical generation and the highest concentrations of Vit C in the body are found in the brain and neuroendocrine tissues, it is suggested that Vit C may change the course of neurological diseases and display potential therapeutic roles. The aim of this review is to update the current state of knowledge of the role of vitamin C on neurodegenerative diseases including Alzheimer's disease, Parkinson's disease, Huntington's disease, multiple sclerosis and amyotrophic sclerosis, as well as psychiatric disorders including depression, anxiety and schizophrenia. The particular attention is attributed to understanding of the mechanisms underlying possible therapeutic properties of ascorbic acid in the presented disorders. |
| doi_str_mv | 10.3390/nu9070659 |
| format | Article |
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Intracellular Vit C helps maintain integrity and function of several processes in the central nervous system (CNS), including neuronal maturation and differentiation, myelin formation, synthesis of catecholamine, modulation of neurotransmission and antioxidant protection. The importance of Vit C for CNS function has been proven by the fact that targeted deletion of the sodium-vitamin C co-transporter in mice results in widespread cerebral hemorrhage and death on post-natal day one. Since neurological diseases are characterized by increased free radical generation and the highest concentrations of Vit C in the body are found in the brain and neuroendocrine tissues, it is suggested that Vit C may change the course of neurological diseases and display potential therapeutic roles. The aim of this review is to update the current state of knowledge of the role of vitamin C on neurodegenerative diseases including Alzheimer's disease, Parkinson's disease, Huntington's disease, multiple sclerosis and amyotrophic sclerosis, as well as psychiatric disorders including depression, anxiety and schizophrenia. The particular attention is attributed to understanding of the mechanisms underlying possible therapeutic properties of ascorbic acid in the presented disorders.</description><identifier>ISSN: 2072-6643</identifier><identifier>EISSN: 2072-6643</identifier><identifier>DOI: 10.3390/nu9070659</identifier><identifier>PMID: 28654017</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Alzheimer disease ; Animals ; Antioxidants ; Antioxidants - administration & dosage ; anxiety ; Ascorbic acid ; Ascorbic Acid - administration & dosage ; Ascorbic Acid - blood ; Behavior disorders ; Brain ; Brain - drug effects ; Brain - metabolism ; Catecholamine ; Catecholamines ; Central nervous system ; Central Nervous System - drug effects ; Central Nervous System - metabolism ; death ; Disease ; Disease Models, Animal ; Free radicals ; Gene deletion ; Hemorrhage ; Humans ; medicinal properties ; Mental depression ; Mental disorders ; Mental Disorders - metabolism ; mice ; Multiple sclerosis ; Myelin ; myelin sheath ; Neurodegenerative Diseases - metabolism ; Neurological diseases ; Neuromodulation ; neurons ; Neurotransmission ; Observational Studies as Topic ; Parkinson disease ; Parkinson's disease ; Randomized Controlled Trials as Topic ; Review ; Schizophrenia ; sclerosis ; Sodium ; therapeutics ; tissues ; Vitamin C</subject><ispartof>Nutrients, 2017-06, Vol.9 (7), p.659</ispartof><rights>2017. This work is licensed under https://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2017 by the authors. 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c502t-11b26eddafccba57ffc9915e4d346bce51494c7843f8c36a0eaffcd95948d0793</citedby><cites>FETCH-LOGICAL-c502t-11b26eddafccba57ffc9915e4d346bce51494c7843f8c36a0eaffcd95948d0793</cites><orcidid>0000-0002-3637-2856 ; 0000-0003-4665-6286</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5537779/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5537779/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27903,27904,53770,53772</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28654017$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kocot, Joanna</creatorcontrib><creatorcontrib>Luchowska-Kocot, Dorota</creatorcontrib><creatorcontrib>Kiełczykowska, Małgorzata</creatorcontrib><creatorcontrib>Musik, Irena</creatorcontrib><creatorcontrib>Kurzepa, Jacek</creatorcontrib><title>Does Vitamin C Influence Neurodegenerative Diseases and Psychiatric Disorders?</title><title>Nutrients</title><addtitle>Nutrients</addtitle><description>Vitamin C (Vit C) is considered to be a vital antioxidant molecule in the brain. Intracellular Vit C helps maintain integrity and function of several processes in the central nervous system (CNS), including neuronal maturation and differentiation, myelin formation, synthesis of catecholamine, modulation of neurotransmission and antioxidant protection. The importance of Vit C for CNS function has been proven by the fact that targeted deletion of the sodium-vitamin C co-transporter in mice results in widespread cerebral hemorrhage and death on post-natal day one. Since neurological diseases are characterized by increased free radical generation and the highest concentrations of Vit C in the body are found in the brain and neuroendocrine tissues, it is suggested that Vit C may change the course of neurological diseases and display potential therapeutic roles. The aim of this review is to update the current state of knowledge of the role of vitamin C on neurodegenerative diseases including Alzheimer's disease, Parkinson's disease, Huntington's disease, multiple sclerosis and amyotrophic sclerosis, as well as psychiatric disorders including depression, anxiety and schizophrenia. The particular attention is attributed to understanding of the mechanisms underlying possible therapeutic properties of ascorbic acid in the presented disorders.</description><subject>Alzheimer disease</subject><subject>Animals</subject><subject>Antioxidants</subject><subject>Antioxidants - administration & dosage</subject><subject>anxiety</subject><subject>Ascorbic acid</subject><subject>Ascorbic Acid - administration & dosage</subject><subject>Ascorbic Acid - blood</subject><subject>Behavior disorders</subject><subject>Brain</subject><subject>Brain - drug effects</subject><subject>Brain - metabolism</subject><subject>Catecholamine</subject><subject>Catecholamines</subject><subject>Central nervous system</subject><subject>Central Nervous System - drug effects</subject><subject>Central Nervous System - metabolism</subject><subject>death</subject><subject>Disease</subject><subject>Disease Models, Animal</subject><subject>Free radicals</subject><subject>Gene deletion</subject><subject>Hemorrhage</subject><subject>Humans</subject><subject>medicinal properties</subject><subject>Mental depression</subject><subject>Mental disorders</subject><subject>Mental Disorders - metabolism</subject><subject>mice</subject><subject>Multiple sclerosis</subject><subject>Myelin</subject><subject>myelin sheath</subject><subject>Neurodegenerative Diseases - metabolism</subject><subject>Neurological diseases</subject><subject>Neuromodulation</subject><subject>neurons</subject><subject>Neurotransmission</subject><subject>Observational Studies as Topic</subject><subject>Parkinson disease</subject><subject>Parkinson's disease</subject><subject>Randomized Controlled Trials as Topic</subject><subject>Review</subject><subject>Schizophrenia</subject><subject>sclerosis</subject><subject>Sodium</subject><subject>therapeutics</subject><subject>tissues</subject><subject>Vitamin C</subject><issn>2072-6643</issn><issn>2072-6643</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNqFkU1PGzEQhq2qqEE0h_6BaqVeyiHU3x-XVii0gIRoD8DVcuxZMNrY1N5F4t-zIRAFLsxlRnofvZqZF6EvBB8wZvCPNBissBTmA9qlWNGZlJx93JonaFrrLV6VwkqyT2hCtRQcE7WLzo8y1OYq9m4ZUzNvTlPbDZA8NOcwlBzgGhIU18d7aI5iBVdH3KXQ_KsP_ia6vkS_EnIJUOqvz2indV2F6XPfQ5d_fl_MT2Znf49P54dnMy8w7WeELKiEEFzr_cIJ1bbeGCKAB8blwoMg3HCvNGet9kw6DG5EghGG64CVYXvo59r3blgsIXhIfXGdvStx6cqDzS7a10qKN_Y631shmFJPBt-fDUr-P0Dt7TJWD13nEuShWkoV0ZRyTd9FiSGcas30yvXbG_Q2DyWNn7CUYC2UJFyN1P6a8iXXWqDd7E2wXWVqN5mO7NftQzfkS4LsERxrnJI</recordid><startdate>20170627</startdate><enddate>20170627</enddate><creator>Kocot, Joanna</creator><creator>Luchowska-Kocot, Dorota</creator><creator>Kiełczykowska, Małgorzata</creator><creator>Musik, Irena</creator><creator>Kurzepa, Jacek</creator><general>MDPI AG</general><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TS</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>7S9</scope><scope>L.6</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-3637-2856</orcidid><orcidid>https://orcid.org/0000-0003-4665-6286</orcidid></search><sort><creationdate>20170627</creationdate><title>Does Vitamin C Influence Neurodegenerative Diseases and Psychiatric Disorders?</title><author>Kocot, Joanna ; 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Intracellular Vit C helps maintain integrity and function of several processes in the central nervous system (CNS), including neuronal maturation and differentiation, myelin formation, synthesis of catecholamine, modulation of neurotransmission and antioxidant protection. The importance of Vit C for CNS function has been proven by the fact that targeted deletion of the sodium-vitamin C co-transporter in mice results in widespread cerebral hemorrhage and death on post-natal day one. Since neurological diseases are characterized by increased free radical generation and the highest concentrations of Vit C in the body are found in the brain and neuroendocrine tissues, it is suggested that Vit C may change the course of neurological diseases and display potential therapeutic roles. The aim of this review is to update the current state of knowledge of the role of vitamin C on neurodegenerative diseases including Alzheimer's disease, Parkinson's disease, Huntington's disease, multiple sclerosis and amyotrophic sclerosis, as well as psychiatric disorders including depression, anxiety and schizophrenia. The particular attention is attributed to understanding of the mechanisms underlying possible therapeutic properties of ascorbic acid in the presented disorders.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>28654017</pmid><doi>10.3390/nu9070659</doi><orcidid>https://orcid.org/0000-0002-3637-2856</orcidid><orcidid>https://orcid.org/0000-0003-4665-6286</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Alzheimer disease Animals Antioxidants Antioxidants - administration & dosage anxiety Ascorbic acid Ascorbic Acid - administration & dosage Ascorbic Acid - blood Behavior disorders Brain Brain - drug effects Brain - metabolism Catecholamine Catecholamines Central nervous system Central Nervous System - drug effects Central Nervous System - metabolism death Disease Disease Models, Animal Free radicals Gene deletion Hemorrhage Humans medicinal properties Mental depression Mental disorders Mental Disorders - metabolism mice Multiple sclerosis Myelin myelin sheath Neurodegenerative Diseases - metabolism Neurological diseases Neuromodulation neurons Neurotransmission Observational Studies as Topic Parkinson disease Parkinson's disease Randomized Controlled Trials as Topic Review Schizophrenia sclerosis Sodium therapeutics tissues Vitamin C |
| title | Does Vitamin C Influence Neurodegenerative Diseases and Psychiatric Disorders? |
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