Role of autophagy in tumor necrosis factor-α-induced apoptosis of osteoblast cells

The aim of this study is to investigate the role of tumor necrosis factor-α (TNF-α) in apoptosis and autophagy of mouse osteoblast MC3T3-E1 cells, as well as the crosstalk between autophagy and apoptosis. Mouse osteoblast MC3T3-E1 cells were cultured in vitro and treated with 5-fluorouracil (5-FU),...

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Veröffentlicht in:	Journal of investigative medicine 2017-08, Vol.65 (6), p.1014-1020
Hauptverfasser:	Zheng, Liwen, Wang, Wanchun, Ni, Jiangdong, Mao, Xinzhan, Song, Deye, Liu, Tang, Wei, Jianwei, Zhou, Huaying
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - drug effects Autophagy Basic Science/Genetics/Molecular Medicine Biomarkers - metabolism Caspase 3 - metabolism Cell Line Cell Survival - drug effects Mice Microtubule-Associated Proteins - metabolism Osteoblasts - cytology Osteoblasts - drug effects Osteoblasts - ultrastructure Sequestosome-1 Protein - metabolism Time Factors Tumor Necrosis Factor-alpha - pharmacology
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