Chemotherapy with radiotherapy influences time-to-development of radiation-induced sarcomas: a multicenter study
Background: An increasing number and proportion of cancer patients with apparently localised disease are treated with chemotherapy and radiation therapy in contemporary oncology practice. In a pilot study of radiation-induced sarcoma (RIS) patients, we demonstrated that chemotherapy was associated w...
Gespeichert in:
| Veröffentlicht in: | British journal of cancer 2017-07, Vol.117 (3), p.326-331 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 331 |
|---|---|
| container_issue | 3 |
| container_start_page | 326 |
| container_title | British journal of cancer |
| container_volume | 117 |
| creator | Zhang, A Y Judson, I Benson, C Wunder, J S Ray-Coquard, I Grimer, R J Quek, R Wong, E Miah, A B Ferguson, P C Dufresne, A Teh, J Y H Stockler, M Tattersall, M H N |
| description | Background:
An increasing number and proportion of cancer patients with apparently localised disease are treated with chemotherapy and radiation therapy in contemporary oncology practice. In a pilot study of radiation-induced sarcoma (RIS) patients, we demonstrated that chemotherapy was associated with a reduced time to development of RIS. We now present a multi-centre collaborative study to validate this association.
Methods:
This was a retrospective cohort study of RIS cases across five large international sarcoma centres between 1 January 2000 to 31 December 2014. The primary endpoint was time to development of RIS.
Results:
We identified 419 patients with RIS. Chemotherapy for the first malignancy was associated with a shorter time to RIS development (HR 1.37; 95% CI: 1.08–1.72;
P
=0.009). In the multi-variable model, older age (HR 2.11; 95% CI 1.83–2.43;
P |
| doi_str_mv | 10.1038/bjc.2017.198 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5537501</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1923275006</sourcerecordid><originalsourceid>FETCH-LOGICAL-c450t-c65e032cf52ab1e456c4ee8b504b37b06e6b086564f47d019815a8f06f916ed63</originalsourceid><addsrcrecordid>eNptkUFv1DAQhS0EokvhxhlF4sKBLGM7dhIOSGhVoFIlLnC2HGfS9Sqxg-0U7b-vt1tWperJsufzm_f0CHlLYU2BN5-6nVkzoPWats0zsqKCs5I2rH5OVgBQl9AyOCOvYtzlawtN_ZKcsUaKSnK-IvNmi5NPWwx63hd_bdoWQff29GLdMC7oDMYi2QnL5Mseb3D084QuFX64w3Wy3pXW9YvBvog6GD_p-LnQxbSMyZqMYihiWvr9a_Ji0GPEN_fnOfn97eLX5kd59fP75ebrVWkqAak0UiBwZgbBdEexEtJUiE0noOp43YFE2UFOIauhqnvI2anQzQByaKnEXvJz8uWoOy_dhP3BQtCjmoOddNgrr636f-LsVl37GyUErwXQLPDhXiD4PwvGpCYbDY6jduiXqGhLK9EApyyj7x-hO78El-NlinGW9eDg6OORMsHHGHA4maGgDlWqXKU6VJl_NRl_9zDACf7XXQbKIxDzyF1jeLD1KcFb5x-rZw</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1923275006</pqid></control><display><type>article</type><title>Chemotherapy with radiotherapy influences time-to-development of radiation-induced sarcomas: a multicenter study</title><source>MEDLINE</source><source>Nature</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><creator>Zhang, A Y ; Judson, I ; Benson, C ; Wunder, J S ; Ray-Coquard, I ; Grimer, R J ; Quek, R ; Wong, E ; Miah, A B ; Ferguson, P C ; Dufresne, A ; Teh, J Y H ; Stockler, M ; Tattersall, M H N</creator><creatorcontrib>Zhang, A Y ; Judson, I ; Benson, C ; Wunder, J S ; Ray-Coquard, I ; Grimer, R J ; Quek, R ; Wong, E ; Miah, A B ; Ferguson, P C ; Dufresne, A ; Teh, J Y H ; Stockler, M ; Tattersall, M H N</creatorcontrib><description>Background:
An increasing number and proportion of cancer patients with apparently localised disease are treated with chemotherapy and radiation therapy in contemporary oncology practice. In a pilot study of radiation-induced sarcoma (RIS) patients, we demonstrated that chemotherapy was associated with a reduced time to development of RIS. We now present a multi-centre collaborative study to validate this association.
Methods:
This was a retrospective cohort study of RIS cases across five large international sarcoma centres between 1 January 2000 to 31 December 2014. The primary endpoint was time to development of RIS.
Results:
We identified 419 patients with RIS. Chemotherapy for the first malignancy was associated with a shorter time to RIS development (HR 1.37; 95% CI: 1.08–1.72;
P
=0.009). In the multi-variable model, older age (HR 2.11; 95% CI 1.83–2.43;
P
<0.001) and chemotherapy for the first malignancy (HR 1.61; 95% CI 1.26–2.05;
P
<0·001) were independently associated with a shorter time to RIS. Anthracyclines and alkylating agents significantly contribute to the effect.
Conclusions:
This study confirms an association between chemotherapy given for the first malignancy and a shorter time to development of RIS.</description><identifier>ISSN: 0007-0920</identifier><identifier>EISSN: 1532-1827</identifier><identifier>DOI: 10.1038/bjc.2017.198</identifier><identifier>PMID: 28654633</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>692/699/67/1059/485 ; 692/699/67/1059/99 ; 692/699/67/1798 ; Adolescent ; Adult ; Age Factors ; Aged ; Aged, 80 and over ; Alkylating agents ; Alkylation ; Anthracycline ; Anthracyclines - adverse effects ; Antineoplastic Agents - adverse effects ; Antineoplastic Agents, Alkylating - adverse effects ; Background radiation ; Biomedical and Life Sciences ; Biomedicine ; Cancer Research ; Chemotherapy ; Child ; Child, Preschool ; Clinical Study ; Drug Resistance ; Epidemiology ; Female ; Humans ; Infant ; Male ; Malignancy ; Middle Aged ; Molecular Medicine ; Neoplasms - drug therapy ; Neoplasms - radiotherapy ; Neoplasms, Radiation-Induced - etiology ; Neoplasms, Second Primary - etiology ; Oncology ; Radiation ; Radiation therapy ; Retrospective Studies ; Sarcoma ; Sarcoma - etiology ; Time Factors ; Young Adult</subject><ispartof>British journal of cancer, 2017-07, Vol.117 (3), p.326-331</ispartof><rights>The Author(s) 2017</rights><rights>Copyright Nature Publishing Group Jul 25, 2017</rights><rights>Copyright © 2017 Cancer Research UK 2017 Cancer Research UK</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c450t-c65e032cf52ab1e456c4ee8b504b37b06e6b086564f47d019815a8f06f916ed63</citedby><cites>FETCH-LOGICAL-c450t-c65e032cf52ab1e456c4ee8b504b37b06e6b086564f47d019815a8f06f916ed63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5537501/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5537501/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,728,781,785,886,27929,27930,53796,53798</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28654633$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, A Y</creatorcontrib><creatorcontrib>Judson, I</creatorcontrib><creatorcontrib>Benson, C</creatorcontrib><creatorcontrib>Wunder, J S</creatorcontrib><creatorcontrib>Ray-Coquard, I</creatorcontrib><creatorcontrib>Grimer, R J</creatorcontrib><creatorcontrib>Quek, R</creatorcontrib><creatorcontrib>Wong, E</creatorcontrib><creatorcontrib>Miah, A B</creatorcontrib><creatorcontrib>Ferguson, P C</creatorcontrib><creatorcontrib>Dufresne, A</creatorcontrib><creatorcontrib>Teh, J Y H</creatorcontrib><creatorcontrib>Stockler, M</creatorcontrib><creatorcontrib>Tattersall, M H N</creatorcontrib><title>Chemotherapy with radiotherapy influences time-to-development of radiation-induced sarcomas: a multicenter study</title><title>British journal of cancer</title><addtitle>Br J Cancer</addtitle><addtitle>Br J Cancer</addtitle><description>Background:
An increasing number and proportion of cancer patients with apparently localised disease are treated with chemotherapy and radiation therapy in contemporary oncology practice. In a pilot study of radiation-induced sarcoma (RIS) patients, we demonstrated that chemotherapy was associated with a reduced time to development of RIS. We now present a multi-centre collaborative study to validate this association.
Methods:
This was a retrospective cohort study of RIS cases across five large international sarcoma centres between 1 January 2000 to 31 December 2014. The primary endpoint was time to development of RIS.
Results:
We identified 419 patients with RIS. Chemotherapy for the first malignancy was associated with a shorter time to RIS development (HR 1.37; 95% CI: 1.08–1.72;
P
=0.009). In the multi-variable model, older age (HR 2.11; 95% CI 1.83–2.43;
P
<0.001) and chemotherapy for the first malignancy (HR 1.61; 95% CI 1.26–2.05;
P
<0·001) were independently associated with a shorter time to RIS. Anthracyclines and alkylating agents significantly contribute to the effect.
Conclusions:
This study confirms an association between chemotherapy given for the first malignancy and a shorter time to development of RIS.</description><subject>692/699/67/1059/485</subject><subject>692/699/67/1059/99</subject><subject>692/699/67/1798</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Alkylating agents</subject><subject>Alkylation</subject><subject>Anthracycline</subject><subject>Anthracyclines - adverse effects</subject><subject>Antineoplastic Agents - adverse effects</subject><subject>Antineoplastic Agents, Alkylating - adverse effects</subject><subject>Background radiation</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cancer Research</subject><subject>Chemotherapy</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Clinical Study</subject><subject>Drug Resistance</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Humans</subject><subject>Infant</subject><subject>Male</subject><subject>Malignancy</subject><subject>Middle Aged</subject><subject>Molecular Medicine</subject><subject>Neoplasms - drug therapy</subject><subject>Neoplasms - radiotherapy</subject><subject>Neoplasms, Radiation-Induced - etiology</subject><subject>Neoplasms, Second Primary - etiology</subject><subject>Oncology</subject><subject>Radiation</subject><subject>Radiation therapy</subject><subject>Retrospective Studies</subject><subject>Sarcoma</subject><subject>Sarcoma - etiology</subject><subject>Time Factors</subject><subject>Young Adult</subject><issn>0007-0920</issn><issn>1532-1827</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNptkUFv1DAQhS0EokvhxhlF4sKBLGM7dhIOSGhVoFIlLnC2HGfS9Sqxg-0U7b-vt1tWperJsufzm_f0CHlLYU2BN5-6nVkzoPWats0zsqKCs5I2rH5OVgBQl9AyOCOvYtzlawtN_ZKcsUaKSnK-IvNmi5NPWwx63hd_bdoWQff29GLdMC7oDMYi2QnL5Mseb3D084QuFX64w3Wy3pXW9YvBvog6GD_p-LnQxbSMyZqMYihiWvr9a_Ji0GPEN_fnOfn97eLX5kd59fP75ebrVWkqAak0UiBwZgbBdEexEtJUiE0noOp43YFE2UFOIauhqnvI2anQzQByaKnEXvJz8uWoOy_dhP3BQtCjmoOddNgrr636f-LsVl37GyUErwXQLPDhXiD4PwvGpCYbDY6jduiXqGhLK9EApyyj7x-hO78El-NlinGW9eDg6OORMsHHGHA4maGgDlWqXKU6VJl_NRl_9zDACf7XXQbKIxDzyF1jeLD1KcFb5x-rZw</recordid><startdate>20170725</startdate><enddate>20170725</enddate><creator>Zhang, A Y</creator><creator>Judson, I</creator><creator>Benson, C</creator><creator>Wunder, J S</creator><creator>Ray-Coquard, I</creator><creator>Grimer, R J</creator><creator>Quek, R</creator><creator>Wong, E</creator><creator>Miah, A B</creator><creator>Ferguson, P C</creator><creator>Dufresne, A</creator><creator>Teh, J Y H</creator><creator>Stockler, M</creator><creator>Tattersall, M H N</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TO</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20170725</creationdate><title>Chemotherapy with radiotherapy influences time-to-development of radiation-induced sarcomas: a multicenter study</title><author>Zhang, A Y ; Judson, I ; Benson, C ; Wunder, J S ; Ray-Coquard, I ; Grimer, R J ; Quek, R ; Wong, E ; Miah, A B ; Ferguson, P C ; Dufresne, A ; Teh, J Y H ; Stockler, M ; Tattersall, M H N</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c450t-c65e032cf52ab1e456c4ee8b504b37b06e6b086564f47d019815a8f06f916ed63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>692/699/67/1059/485</topic><topic>692/699/67/1059/99</topic><topic>692/699/67/1798</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Age Factors</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Alkylating agents</topic><topic>Alkylation</topic><topic>Anthracycline</topic><topic>Anthracyclines - adverse effects</topic><topic>Antineoplastic Agents - adverse effects</topic><topic>Antineoplastic Agents, Alkylating - adverse effects</topic><topic>Background radiation</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cancer Research</topic><topic>Chemotherapy</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Clinical Study</topic><topic>Drug Resistance</topic><topic>Epidemiology</topic><topic>Female</topic><topic>Humans</topic><topic>Infant</topic><topic>Male</topic><topic>Malignancy</topic><topic>Middle Aged</topic><topic>Molecular Medicine</topic><topic>Neoplasms - drug therapy</topic><topic>Neoplasms - radiotherapy</topic><topic>Neoplasms, Radiation-Induced - etiology</topic><topic>Neoplasms, Second Primary - etiology</topic><topic>Oncology</topic><topic>Radiation</topic><topic>Radiation therapy</topic><topic>Retrospective Studies</topic><topic>Sarcoma</topic><topic>Sarcoma - etiology</topic><topic>Time Factors</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, A Y</creatorcontrib><creatorcontrib>Judson, I</creatorcontrib><creatorcontrib>Benson, C</creatorcontrib><creatorcontrib>Wunder, J S</creatorcontrib><creatorcontrib>Ray-Coquard, I</creatorcontrib><creatorcontrib>Grimer, R J</creatorcontrib><creatorcontrib>Quek, R</creatorcontrib><creatorcontrib>Wong, E</creatorcontrib><creatorcontrib>Miah, A B</creatorcontrib><creatorcontrib>Ferguson, P C</creatorcontrib><creatorcontrib>Dufresne, A</creatorcontrib><creatorcontrib>Teh, J Y H</creatorcontrib><creatorcontrib>Stockler, M</creatorcontrib><creatorcontrib>Tattersall, M H N</creatorcontrib><collection>Springer Nature OA/Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>British journal of cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, A Y</au><au>Judson, I</au><au>Benson, C</au><au>Wunder, J S</au><au>Ray-Coquard, I</au><au>Grimer, R J</au><au>Quek, R</au><au>Wong, E</au><au>Miah, A B</au><au>Ferguson, P C</au><au>Dufresne, A</au><au>Teh, J Y H</au><au>Stockler, M</au><au>Tattersall, M H N</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Chemotherapy with radiotherapy influences time-to-development of radiation-induced sarcomas: a multicenter study</atitle><jtitle>British journal of cancer</jtitle><stitle>Br J Cancer</stitle><addtitle>Br J Cancer</addtitle><date>2017-07-25</date><risdate>2017</risdate><volume>117</volume><issue>3</issue><spage>326</spage><epage>331</epage><pages>326-331</pages><issn>0007-0920</issn><eissn>1532-1827</eissn><abstract>Background:
An increasing number and proportion of cancer patients with apparently localised disease are treated with chemotherapy and radiation therapy in contemporary oncology practice. In a pilot study of radiation-induced sarcoma (RIS) patients, we demonstrated that chemotherapy was associated with a reduced time to development of RIS. We now present a multi-centre collaborative study to validate this association.
Methods:
This was a retrospective cohort study of RIS cases across five large international sarcoma centres between 1 January 2000 to 31 December 2014. The primary endpoint was time to development of RIS.
Results:
We identified 419 patients with RIS. Chemotherapy for the first malignancy was associated with a shorter time to RIS development (HR 1.37; 95% CI: 1.08–1.72;
P
=0.009). In the multi-variable model, older age (HR 2.11; 95% CI 1.83–2.43;
P
<0.001) and chemotherapy for the first malignancy (HR 1.61; 95% CI 1.26–2.05;
P
<0·001) were independently associated with a shorter time to RIS. Anthracyclines and alkylating agents significantly contribute to the effect.
Conclusions:
This study confirms an association between chemotherapy given for the first malignancy and a shorter time to development of RIS.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>28654633</pmid><doi>10.1038/bjc.2017.198</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0007-0920 |
| ispartof | British journal of cancer, 2017-07, Vol.117 (3), p.326-331 |
| issn | 0007-0920 1532-1827 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5537501 |
| source | MEDLINE; Nature; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | 692/699/67/1059/485 692/699/67/1059/99 692/699/67/1798 Adolescent Adult Age Factors Aged Aged, 80 and over Alkylating agents Alkylation Anthracycline Anthracyclines - adverse effects Antineoplastic Agents - adverse effects Antineoplastic Agents, Alkylating - adverse effects Background radiation Biomedical and Life Sciences Biomedicine Cancer Research Chemotherapy Child Child, Preschool Clinical Study Drug Resistance Epidemiology Female Humans Infant Male Malignancy Middle Aged Molecular Medicine Neoplasms - drug therapy Neoplasms - radiotherapy Neoplasms, Radiation-Induced - etiology Neoplasms, Second Primary - etiology Oncology Radiation Radiation therapy Retrospective Studies Sarcoma Sarcoma - etiology Time Factors Young Adult |
| title | Chemotherapy with radiotherapy influences time-to-development of radiation-induced sarcomas: a multicenter study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-11T21%3A46%3A39IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Chemotherapy%20with%20radiotherapy%20influences%20time-to-development%20of%20radiation-induced%20sarcomas:%20a%20multicenter%20study&rft.jtitle=British%20journal%20of%20cancer&rft.au=Zhang,%20A%20Y&rft.date=2017-07-25&rft.volume=117&rft.issue=3&rft.spage=326&rft.epage=331&rft.pages=326-331&rft.issn=0007-0920&rft.eissn=1532-1827&rft_id=info:doi/10.1038/bjc.2017.198&rft_dat=%3Cproquest_pubme%3E1923275006%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1923275006&rft_id=info:pmid/28654633&rfr_iscdi=true |