Impact of novel miR-145-3p regulatory networks on survival in patients with castration-resistant prostate cancer

Background: Despite recent advancements, metastatic castration-resistant prostate cancer (CRPC) is not considered curative. Novel approaches for identification of therapeutic targets of CRPC are needed. Methods: Next-generation sequencing revealed 945–1248 miRNAs from each lethal mCRPC sample. We co...

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Veröffentlicht in:	British journal of cancer 2017-07, Vol.117 (3), p.409-420
Hauptverfasser:	Goto, Yusuke, Kurozumi, Akira, Arai, Takayuki, Nohata, Nijiro, Kojima, Satoko, Okato, Atsushi, Kato, Mayuko, Yamazaki, Kazuto, Ishida, Yasuo, Naya, Yukio, Ichikawa, Tomohiko, Seki, Naohiko
Format:	Artikel
Sprache:	eng
Schlagworte:	631/208/514/1949 631/337/384/331 692/699/2768/589/466 692/699/67/1059/2326 Argonaute Proteins - genetics Biomedical and Life Sciences Biomedicine Cancer Research Castration CDC2 Protein Kinase Cell Cycle Proteins - genetics Cell Line, Tumor Computer Simulation Cyclin-Dependent Kinases - genetics Disease-Free Survival Down-Regulation Drug Resistance Epidemiology Gene Expression Gene Expression Regulation, Neoplastic Genetics & Genomics genetics-and-genomics Genome-Wide Association Study Genomes Humans Lymphatic Metastasis Male Metastases MicroRNAs - genetics Middle Aged miRNA Molecular Medicine Neoplasm Metastasis Neoplasm Staging Oncology Passengers Prostate Prostate cancer Prostatic Neoplasms, Castration-Resistant - genetics Prostatic Neoplasms, Castration-Resistant - pathology Protein Serine-Threonine Kinases - genetics Ribonucleic acid RNA RNA-Induced Silencing Complex Sequence Analysis, RNA Survival Survival Rate
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