The role of IL-6 in neurodevelopment after prenatal stress

Highlights • Microglia and maternal IL-6 may be involved in the effects of prenatal stress. . • Prenatal stress effects on embryonic and adult microglia involved prenatal IL-6. . • GABAergic progenitor migration was delayed by prenatal stress and IL-6. • Prenatal stress behaviors did not show a role...

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Veröffentlicht in:	Brain, behavior, and immunity behavior, and immunity, 2017-10, Vol.65, p.274-283
Hauptverfasser:	Gumusoglu, Serena B, Fine, Rebecca S, Murray, Samuel J, Bittle, Jada L, Stevens, Hanna E
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Animals Anxiety - immunology Behavior, Animal - drug effects Brain - metabolism Cytokines - metabolism Disease Models, Animal Embryonic Female Gaba GABA Agents - pharmacology GABAergic Neurons - drug effects IL-6 Interleukin-6 - metabolism Interleukin-6 - pharmacology Interleukin-6 - physiology Male Mice Microglia Microglia - drug effects Pregnancy Prenatal Exposure Delayed Effects - immunology Prenatal stress Psychiatry Stress, Psychological - immunology
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Beschreibung
Zusammenfassung:	Highlights • Microglia and maternal IL-6 may be involved in the effects of prenatal stress. . • Prenatal stress effects on embryonic and adult microglia involved prenatal IL-6. . • GABAergic progenitor migration was delayed by prenatal stress and IL-6. • Prenatal stress behaviors did not show a role for prenatal IL-6. • Prenatal stress behaviors correlated more with GABAergic changes than with microglia.
ISSN:	0889-1591 1090-2139
DOI:	10.1016/j.bbi.2017.05.015