Indoxyl sulfate, a uremic toxin in chronic kidney disease, suppresses both bone formation and bone resorption

Abnormalities of bone turnover are commonly observed in patients with chronic kidney disease (CKD), and the low‐turnover bone disease is considered to be associated with low serum parathyroid hormone (PTH) levels and skeletal resistance to PTH. Indoxyl sulfate (IS) is a representative uremic toxin t...

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Veröffentlicht in:	FEBS open bio 2017-08, Vol.7 (8), p.1178-1185
Hauptverfasser:	Watanabe, Kenta, Tominari, Tsukasa, Hirata, Michiko, Matsumoto, Chiho, Hirata, Junya, Murphy, Gillian, Nagase, Hideaki, Miyaura, Chisato, Inada, Masaki
Format:	Artikel
Sprache:	eng
Schlagworte:	Bone diseases bone formation Bone growth bone loss Bone marrow Bone morphogenetic protein 2 Bone resorption Bone turnover Cell differentiation chronic kidney disease Cytokines Fractures Gene expression Glial stem cells Hemodialysis indoxyl sulfate Kidney diseases Ligands Macrophages Menopause Mortality Nodules osteoblast Osteoblasts Osteocalcin osteoclast Osteoclastogenesis Osteoclasts Osteogenesis Osteoprogenitor cells Parathyroid Parathyroid hormone Parathyroidectomy Pathogenesis Phosphatase Proteins Studies Sulfates Toxins TRANCE protein Transcription factors
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