Three-dimensional structural analysis reveals a Cdk5-mediated kinase cascade regulating hepatic biliary network branching in zebrafish

The intrahepatic biliary network is a highly branched three-dimensional network lined by biliary epithelial cells, but how its branching patterns are precisely established is not clear. We designed a new computer-based algorithm that quantitatively computes the structural differences of the three-di...

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Veröffentlicht in:	Development (Cambridge) 2017-07, Vol.144 (14), p.2595-2605
Hauptverfasser:	Dimri, Manali, Bilogan, Cassandra, Pierce, Lain X, Naegele, Gregory, Vasanji, Amit, Gibson, Isabel, McClendon, Allyson, Tae, Kevin, Sakaguchi, Takuya F
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin Actin Depolymerizing Factors - metabolism Algorithms Animals Animals, Genetically Modified Bile Ducts, Intrahepatic - enzymology Bile Ducts, Intrahepatic - growth & development Computer Simulation Cyclin-dependent kinase 5 Cyclin-Dependent Kinase 5 - antagonists & inhibitors Cyclin-Dependent Kinase 5 - genetics Cyclin-Dependent Kinase 5 - metabolism Cyclin-dependent kinases Danio rerio Epithelial cells Gene Knockout Techniques Imaging, Three-Dimensional Larva - growth & development Larva - metabolism Lim Kinases - metabolism Liver Models, Anatomic Morphogenesis Morphogenesis - drug effects Morphogenesis - genetics Morphogenesis - physiology Mutation p21-Activated Kinases - metabolism Protein Kinase Inhibitors - pharmacology Signal Transduction Zebrafish - genetics Zebrafish - growth & development Zebrafish - metabolism Zebrafish Proteins - antagonists & inhibitors Zebrafish Proteins - genetics Zebrafish Proteins - metabolism
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