Deregulation of CRTCs in Aging and Age-Related Disease Risk
Advances in public health in the past century have seen a sharp increase in human life expectancy. With these changes have come an increased prevalence of age-related pathologies and health burdens in the elderly. Patient age is the biggest risk factor for multiple chronic conditions that often occu...
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| Veröffentlicht in: | Trends in genetics 2017-05, Vol.33 (5), p.303-321 |
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| creator | Escoubas, Caroline C Silva-García, Carlos G Mair, William B |
| description | Advances in public health in the past century have seen a sharp increase in human life expectancy. With these changes have come an increased prevalence of age-related pathologies and health burdens in the elderly. Patient age is the biggest risk factor for multiple chronic conditions that often occur simultaneously within a single individual. An alternative to disease-centric therapeutic approaches is that of ‘geroscience’, which aims to define molecular mechanisms that link age to overall disease risk. One such mechanism is deregulation of CREB-regulated transcriptional coactivators (CRTCs). Initially identified for their role in modulating CREB transcription, the past 5 years has seen an expansion in knowledge of new cellular regulators and roles of CRTCs beyond CREB. CRTCs have been shown to modulate organismal aging in Caenorhabditis elegans and to impact on age-related diseases in humans. We discuss CRTC deregulation as a new driver of aging that integrates the link between age and disease risk. |
| doi_str_mv | 10.1016/j.tig.2017.03.002 |
| format | Article |
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With these changes have come an increased prevalence of age-related pathologies and health burdens in the elderly. Patient age is the biggest risk factor for multiple chronic conditions that often occur simultaneously within a single individual. An alternative to disease-centric therapeutic approaches is that of ‘geroscience’, which aims to define molecular mechanisms that link age to overall disease risk. One such mechanism is deregulation of CREB-regulated transcriptional coactivators (CRTCs). Initially identified for their role in modulating CREB transcription, the past 5 years has seen an expansion in knowledge of new cellular regulators and roles of CRTCs beyond CREB. CRTCs have been shown to modulate organismal aging in Caenorhabditis elegans and to impact on age-related diseases in humans. 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We discuss CRTC deregulation as a new driver of aging that integrates the link between age and disease risk.</description><subject>aging</subject><subject>Aging - genetics</subject><subject>Aging - pathology</subject><subject>Animals</subject><subject>cancer</subject><subject>CREB-regulated transcriptional coactivators</subject><subject>Disease Models, Animal</subject><subject>Humans</subject><subject>Medical Education</subject><subject>metabolic disease</subject><subject>neurodegeneration</subject><subject>Phosphorylation</subject><subject>Risk Factors</subject><subject>Trans-Activators - genetics</subject><subject>Transcription, Genetic</subject><issn>0168-9525</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc1u1DAURr0A0VJ4ADYoSzYJ13YcJ6pUqZryJ1VCGsr6ynGug6cZp9hJpb49Hk2pgAUrW_b5PlvnMvaGQ8WBN-931eLHSgDXFcgKQDxjp_m8LTsl1Al7mdIOAJSW6gU7Ea1sFK_hlJ1fUaRxnczi51DMrthsbzap8KG4HH0YCxOGvKNySxmhobjyiUyiYuvT7Sv23Jkp0evH9Yx9__jhZvO5vP766cvm8rq0SouldKSNGDqQ2qhemtoJ1YhB971uTNeAq50hozQ56AahaxJNb1sNVJPVHTiQZ-zi2Hu39nsaLIUlmgnvot-b-ICz8fj3TfA_cJzvUSnZtJ3OBe8eC-L8c6W04N4nS9NkAs1rQt62sq0FF3VG-RG1cU4pknt6hgMeROMOs2g8iEaQmEXnzNs___eU-G05A-dHgLKle08Rk_UULA0-kl1wmP1_6y_-SdvJB2_NdEsPlHbzGkPWjxyTQMBvh6kfhs61BJCNlr8AC5qkwQ</recordid><startdate>20170501</startdate><enddate>20170501</enddate><creator>Escoubas, Caroline C</creator><creator>Silva-García, Carlos G</creator><creator>Mair, William B</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20170501</creationdate><title>Deregulation of CRTCs in Aging and Age-Related Disease Risk</title><author>Escoubas, Caroline C ; Silva-García, Carlos G ; Mair, William B</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c572t-fe7a2d9037a5b3a4f2562d7bb76a960f4faea57ef09d274e26bc870e4ec790f03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>aging</topic><topic>Aging - genetics</topic><topic>Aging - pathology</topic><topic>Animals</topic><topic>cancer</topic><topic>CREB-regulated transcriptional coactivators</topic><topic>Disease Models, Animal</topic><topic>Humans</topic><topic>Medical Education</topic><topic>metabolic disease</topic><topic>neurodegeneration</topic><topic>Phosphorylation</topic><topic>Risk Factors</topic><topic>Trans-Activators - genetics</topic><topic>Transcription, Genetic</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Escoubas, Caroline C</creatorcontrib><creatorcontrib>Silva-García, Carlos G</creatorcontrib><creatorcontrib>Mair, William B</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Trends in genetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Escoubas, Caroline C</au><au>Silva-García, Carlos G</au><au>Mair, William B</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Deregulation of CRTCs in Aging and Age-Related Disease Risk</atitle><jtitle>Trends in genetics</jtitle><addtitle>Trends Genet</addtitle><date>2017-05-01</date><risdate>2017</risdate><volume>33</volume><issue>5</issue><spage>303</spage><epage>321</epage><pages>303-321</pages><issn>0168-9525</issn><abstract>Advances in public health in the past century have seen a sharp increase in human life expectancy. With these changes have come an increased prevalence of age-related pathologies and health burdens in the elderly. Patient age is the biggest risk factor for multiple chronic conditions that often occur simultaneously within a single individual. An alternative to disease-centric therapeutic approaches is that of ‘geroscience’, which aims to define molecular mechanisms that link age to overall disease risk. One such mechanism is deregulation of CREB-regulated transcriptional coactivators (CRTCs). Initially identified for their role in modulating CREB transcription, the past 5 years has seen an expansion in knowledge of new cellular regulators and roles of CRTCs beyond CREB. CRTCs have been shown to modulate organismal aging in Caenorhabditis elegans and to impact on age-related diseases in humans. 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| ispartof | Trends in genetics, 2017-05, Vol.33 (5), p.303-321 |
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| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | aging Aging - genetics Aging - pathology Animals cancer CREB-regulated transcriptional coactivators Disease Models, Animal Humans Medical Education metabolic disease neurodegeneration Phosphorylation Risk Factors Trans-Activators - genetics Transcription, Genetic |
| title | Deregulation of CRTCs in Aging and Age-Related Disease Risk |
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