Single-molecule probing of amyloid nano-ensembles using the polymer nanoarray approach

Soluble amyloid-beta (Aβ) oligomers are the prime causative agents of cognitive deficits during early stages of Alzheimer's disease (AD). The transient nature of the oligomers makes them difficult to characterize by traditional techniques, suggesting that advanced approaches are necessary. Prev...

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Veröffentlicht in:	Physical chemistry chemical physics : PCCP 2017-06, Vol.19 (25), p.16387-16394
Hauptverfasser:	Maity, Sibaprasad, Viazovkina, Ekaterina, Gall, Alexander, Lyubchenko, Yuri L
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - metabolism Alzheimer Disease - pathology Alzheimer's disease Amyloid beta-Peptides - chemistry Amyloid beta-Peptides - metabolism Assembly Dimerization Humans Hydrogen-Ion Concentration Microscopy, Atomic Force Nanostructure Nanotechnology Oligomers Polymers - chemistry Protein Array Analysis Protein Multimerization Segments Spectroscopy Surface Properties Trimers
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