Estimation of heritability for nine common cancers using data from genome‐wide association studies in Chinese population

The familial aggregation indicated the inheritance of cancer risk. Recent genome‐wide association studies (GWASs) have identified a number of common single‐nucleotide polymorphisms (SNPs). Following heritability analyses have shown that SNPs could explain a moderate amount of variance for different...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:International journal of cancer 2017-01, Vol.140 (2), p.329-336
Hauptverfasser: Dai, Juncheng, Shen, Wei, Wen, Wanqing, Chang, Jiang, Wang, Tongmin, Chen, Haitao, Jin, Guangfu, Ma, Hongxia, Wu, Chen, Li, Lian, Song, Fengju, Zeng, YiXin, Jiang, Yue, Chen, Jiaping, Wang, Cheng, Zhu, Meng, Zhou, Wen, Du, Jiangbo, Xiang, Yongbing, Shu, Xiao‐Ou, Hu, Zhibin, Zhou, Weiping, Chen, Kexin, Xu, Jianfeng, Jia, Weihua, Lin, Dongxin, Zheng, Wei, Shen, Hongbing
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 336
container_issue 2
container_start_page 329
container_title International journal of cancer
container_volume 140
creator Dai, Juncheng
Shen, Wei
Wen, Wanqing
Chang, Jiang
Wang, Tongmin
Chen, Haitao
Jin, Guangfu
Ma, Hongxia
Wu, Chen
Li, Lian
Song, Fengju
Zeng, YiXin
Jiang, Yue
Chen, Jiaping
Wang, Cheng
Zhu, Meng
Zhou, Wen
Du, Jiangbo
Xiang, Yongbing
Shu, Xiao‐Ou
Hu, Zhibin
Zhou, Weiping
Chen, Kexin
Xu, Jianfeng
Jia, Weihua
Lin, Dongxin
Zheng, Wei
Shen, Hongbing
description The familial aggregation indicated the inheritance of cancer risk. Recent genome‐wide association studies (GWASs) have identified a number of common single‐nucleotide polymorphisms (SNPs). Following heritability analyses have shown that SNPs could explain a moderate amount of variance for different cancer phenotypes among Caucasians. However, little information was available in Chinese population. We performed a genome‐wide complex trait analysis for common cancers at nine anatomical sites in Chinese population (14,629 cancer cases vs. 17,554 controls) and estimated the heritability of these cancers based on the common SNPs. We found that common SNPs explained certain amount of heritability with significance for all nine cancer sites: gastric cancer (20.26%), esophageal squamous cell carcinoma (19.86%), colorectal cancer (16.30%), lung cancer (LC) (15.17%), and epithelial ovarian cancer (13.31%), and a similar heritability around 10% for hepatitis B virus‐related hepatocellular carcinoma, prostate cancer, breast cancer and nasopharyngeal carcinoma. We found that nearly or less than 25% change was shown when removing the regions expanding 250 kb or 500 kb upward and downward of the GWAS‐reported SNPs. We also found strong linear correlations between variance partitioned by each chromosome and chromosomal length only for LC (R2 = 0.641, p = 0.001) and esophageal squamous cell cancer (R2 = 0.633, p = 0.002), which implied us the complex heterogeneity of cancers. These results indicate polygenic genetic architecture of the nine common cancers in Chinese population. Further efforts should be made to discover the hidden heritability of different cancer types among Chinese. What's new? Almost every cancer exhibits familial aggregation. Here, the authors conducted a genome‐wide complex trait analysis in Chinese participants in previous genome‐wide association studies to estimate heritability explained by single‐nucleotide polymorphisms for nine common cancers (gastric, esophageal, colorectal, lung, ovarian, hepatocellular, prostrate, breast, and nasopharyngeal). The explained heritability ranged from 10.19% to 20.26% indicating a polygenic architecture of all examined cancer types. The authors recommend performing even larger studies to better analyze the hidden heritability of each cancer type.
doi_str_mv 10.1002/ijc.30447
format Article
fullrecord <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5536238</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1835397426</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4767-c9ae8ac2a48a62bcef3f96dc0c72b4f69b33a23cc098de53f7bbd430cc4c58393</originalsourceid><addsrcrecordid>eNqNkc1u1DAURi0EokNhwQsgS2xgkdZ_seMNEhq1UFSJDawtx7mZ8SixBzuhGlY8As_YJ8FtSgVISKzu4js6uvd-CD2n5IQSwk79zp1wIoR6gFaUaFURRuuHaFUyUinK5RF6kvOOEEprIh6jI6akbHQjV-jbWZ78aCcfA4493kLyk2394KcD7mPCwQfALo5jyZ0NDlLGc_Zhgzs7WdynOOINhDjC9fcfV74DbHOOzi_GPM2dh4x9wOttMWXA-7ifh9v0KXrU2yHDs7t5jD6fn31av68uP767WL-9rJxQUlVOW2isY1Y0VrLWQc97LTtHnGKt6KVuObeMO0d000HNe9W2neDEOeHqhmt-jN4s3v3cjtA5CFOyg9mncnc6mGi9-TMJfms28aupay4Zb4rg1Z0gxS8z5MmMPjsYBhsgztnQpiZKUU34f6C85loJJgv68i90F-cUyicKJYSWmjY31OuFcinmnKC_35sSc1O-KeWb2_IL--L3Q-_JX20X4HQBrvwAh3-bzMWH9aL8CfWbvSI</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1844969186</pqid></control><display><type>article</type><title>Estimation of heritability for nine common cancers using data from genome‐wide association studies in Chinese population</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Access via Wiley Online Library</source><creator>Dai, Juncheng ; Shen, Wei ; Wen, Wanqing ; Chang, Jiang ; Wang, Tongmin ; Chen, Haitao ; Jin, Guangfu ; Ma, Hongxia ; Wu, Chen ; Li, Lian ; Song, Fengju ; Zeng, YiXin ; Jiang, Yue ; Chen, Jiaping ; Wang, Cheng ; Zhu, Meng ; Zhou, Wen ; Du, Jiangbo ; Xiang, Yongbing ; Shu, Xiao‐Ou ; Hu, Zhibin ; Zhou, Weiping ; Chen, Kexin ; Xu, Jianfeng ; Jia, Weihua ; Lin, Dongxin ; Zheng, Wei ; Shen, Hongbing</creator><creatorcontrib>Dai, Juncheng ; Shen, Wei ; Wen, Wanqing ; Chang, Jiang ; Wang, Tongmin ; Chen, Haitao ; Jin, Guangfu ; Ma, Hongxia ; Wu, Chen ; Li, Lian ; Song, Fengju ; Zeng, YiXin ; Jiang, Yue ; Chen, Jiaping ; Wang, Cheng ; Zhu, Meng ; Zhou, Wen ; Du, Jiangbo ; Xiang, Yongbing ; Shu, Xiao‐Ou ; Hu, Zhibin ; Zhou, Weiping ; Chen, Kexin ; Xu, Jianfeng ; Jia, Weihua ; Lin, Dongxin ; Zheng, Wei ; Shen, Hongbing</creatorcontrib><description>The familial aggregation indicated the inheritance of cancer risk. Recent genome‐wide association studies (GWASs) have identified a number of common single‐nucleotide polymorphisms (SNPs). Following heritability analyses have shown that SNPs could explain a moderate amount of variance for different cancer phenotypes among Caucasians. However, little information was available in Chinese population. We performed a genome‐wide complex trait analysis for common cancers at nine anatomical sites in Chinese population (14,629 cancer cases vs. 17,554 controls) and estimated the heritability of these cancers based on the common SNPs. We found that common SNPs explained certain amount of heritability with significance for all nine cancer sites: gastric cancer (20.26%), esophageal squamous cell carcinoma (19.86%), colorectal cancer (16.30%), lung cancer (LC) (15.17%), and epithelial ovarian cancer (13.31%), and a similar heritability around 10% for hepatitis B virus‐related hepatocellular carcinoma, prostate cancer, breast cancer and nasopharyngeal carcinoma. We found that nearly or less than 25% change was shown when removing the regions expanding 250 kb or 500 kb upward and downward of the GWAS‐reported SNPs. We also found strong linear correlations between variance partitioned by each chromosome and chromosomal length only for LC (R2 = 0.641, p = 0.001) and esophageal squamous cell cancer (R2 = 0.633, p = 0.002), which implied us the complex heterogeneity of cancers. These results indicate polygenic genetic architecture of the nine common cancers in Chinese population. Further efforts should be made to discover the hidden heritability of different cancer types among Chinese. What's new? Almost every cancer exhibits familial aggregation. Here, the authors conducted a genome‐wide complex trait analysis in Chinese participants in previous genome‐wide association studies to estimate heritability explained by single‐nucleotide polymorphisms for nine common cancers (gastric, esophageal, colorectal, lung, ovarian, hepatocellular, prostrate, breast, and nasopharyngeal). The explained heritability ranged from 10.19% to 20.26% indicating a polygenic architecture of all examined cancer types. The authors recommend performing even larger studies to better analyze the hidden heritability of each cancer type.</description><identifier>ISSN: 0020-7136</identifier><identifier>EISSN: 1097-0215</identifier><identifier>DOI: 10.1002/ijc.30447</identifier><identifier>PMID: 27668986</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Asian Continental Ancestry Group - genetics ; Cancer ; Chinese population ; Chromosomes - genetics ; Female ; Genetic Predisposition to Disease - genetics ; Genome-Wide Association Study - methods ; genome‐wide complex trait analysis ; Genomics ; Hepatitis B virus ; heritability ; Humans ; Male ; Medical research ; Multifactorial Inheritance - genetics ; Neoplasms - etiology ; Neoplasms - genetics ; Phenotype ; Polymorphism, Single Nucleotide - genetics ; Population genetics ; single‐nucleotide polymorphisms</subject><ispartof>International journal of cancer, 2017-01, Vol.140 (2), p.329-336</ispartof><rights>2016 UICC</rights><rights>2016 UICC.</rights><rights>2017 UICC</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4767-c9ae8ac2a48a62bcef3f96dc0c72b4f69b33a23cc098de53f7bbd430cc4c58393</citedby><cites>FETCH-LOGICAL-c4767-c9ae8ac2a48a62bcef3f96dc0c72b4f69b33a23cc098de53f7bbd430cc4c58393</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fijc.30447$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fijc.30447$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,315,781,785,886,1418,27928,27929,45578,45579</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27668986$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dai, Juncheng</creatorcontrib><creatorcontrib>Shen, Wei</creatorcontrib><creatorcontrib>Wen, Wanqing</creatorcontrib><creatorcontrib>Chang, Jiang</creatorcontrib><creatorcontrib>Wang, Tongmin</creatorcontrib><creatorcontrib>Chen, Haitao</creatorcontrib><creatorcontrib>Jin, Guangfu</creatorcontrib><creatorcontrib>Ma, Hongxia</creatorcontrib><creatorcontrib>Wu, Chen</creatorcontrib><creatorcontrib>Li, Lian</creatorcontrib><creatorcontrib>Song, Fengju</creatorcontrib><creatorcontrib>Zeng, YiXin</creatorcontrib><creatorcontrib>Jiang, Yue</creatorcontrib><creatorcontrib>Chen, Jiaping</creatorcontrib><creatorcontrib>Wang, Cheng</creatorcontrib><creatorcontrib>Zhu, Meng</creatorcontrib><creatorcontrib>Zhou, Wen</creatorcontrib><creatorcontrib>Du, Jiangbo</creatorcontrib><creatorcontrib>Xiang, Yongbing</creatorcontrib><creatorcontrib>Shu, Xiao‐Ou</creatorcontrib><creatorcontrib>Hu, Zhibin</creatorcontrib><creatorcontrib>Zhou, Weiping</creatorcontrib><creatorcontrib>Chen, Kexin</creatorcontrib><creatorcontrib>Xu, Jianfeng</creatorcontrib><creatorcontrib>Jia, Weihua</creatorcontrib><creatorcontrib>Lin, Dongxin</creatorcontrib><creatorcontrib>Zheng, Wei</creatorcontrib><creatorcontrib>Shen, Hongbing</creatorcontrib><title>Estimation of heritability for nine common cancers using data from genome‐wide association studies in Chinese population</title><title>International journal of cancer</title><addtitle>Int J Cancer</addtitle><description>The familial aggregation indicated the inheritance of cancer risk. Recent genome‐wide association studies (GWASs) have identified a number of common single‐nucleotide polymorphisms (SNPs). Following heritability analyses have shown that SNPs could explain a moderate amount of variance for different cancer phenotypes among Caucasians. However, little information was available in Chinese population. We performed a genome‐wide complex trait analysis for common cancers at nine anatomical sites in Chinese population (14,629 cancer cases vs. 17,554 controls) and estimated the heritability of these cancers based on the common SNPs. We found that common SNPs explained certain amount of heritability with significance for all nine cancer sites: gastric cancer (20.26%), esophageal squamous cell carcinoma (19.86%), colorectal cancer (16.30%), lung cancer (LC) (15.17%), and epithelial ovarian cancer (13.31%), and a similar heritability around 10% for hepatitis B virus‐related hepatocellular carcinoma, prostate cancer, breast cancer and nasopharyngeal carcinoma. We found that nearly or less than 25% change was shown when removing the regions expanding 250 kb or 500 kb upward and downward of the GWAS‐reported SNPs. We also found strong linear correlations between variance partitioned by each chromosome and chromosomal length only for LC (R2 = 0.641, p = 0.001) and esophageal squamous cell cancer (R2 = 0.633, p = 0.002), which implied us the complex heterogeneity of cancers. These results indicate polygenic genetic architecture of the nine common cancers in Chinese population. Further efforts should be made to discover the hidden heritability of different cancer types among Chinese. What's new? Almost every cancer exhibits familial aggregation. Here, the authors conducted a genome‐wide complex trait analysis in Chinese participants in previous genome‐wide association studies to estimate heritability explained by single‐nucleotide polymorphisms for nine common cancers (gastric, esophageal, colorectal, lung, ovarian, hepatocellular, prostrate, breast, and nasopharyngeal). The explained heritability ranged from 10.19% to 20.26% indicating a polygenic architecture of all examined cancer types. The authors recommend performing even larger studies to better analyze the hidden heritability of each cancer type.</description><subject>Asian Continental Ancestry Group - genetics</subject><subject>Cancer</subject><subject>Chinese population</subject><subject>Chromosomes - genetics</subject><subject>Female</subject><subject>Genetic Predisposition to Disease - genetics</subject><subject>Genome-Wide Association Study - methods</subject><subject>genome‐wide complex trait analysis</subject><subject>Genomics</subject><subject>Hepatitis B virus</subject><subject>heritability</subject><subject>Humans</subject><subject>Male</subject><subject>Medical research</subject><subject>Multifactorial Inheritance - genetics</subject><subject>Neoplasms - etiology</subject><subject>Neoplasms - genetics</subject><subject>Phenotype</subject><subject>Polymorphism, Single Nucleotide - genetics</subject><subject>Population genetics</subject><subject>single‐nucleotide polymorphisms</subject><issn>0020-7136</issn><issn>1097-0215</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkc1u1DAURi0EokNhwQsgS2xgkdZ_seMNEhq1UFSJDawtx7mZ8SixBzuhGlY8As_YJ8FtSgVISKzu4js6uvd-CD2n5IQSwk79zp1wIoR6gFaUaFURRuuHaFUyUinK5RF6kvOOEEprIh6jI6akbHQjV-jbWZ78aCcfA4493kLyk2394KcD7mPCwQfALo5jyZ0NDlLGc_Zhgzs7WdynOOINhDjC9fcfV74DbHOOzi_GPM2dh4x9wOttMWXA-7ifh9v0KXrU2yHDs7t5jD6fn31av68uP767WL-9rJxQUlVOW2isY1Y0VrLWQc97LTtHnGKt6KVuObeMO0d000HNe9W2neDEOeHqhmt-jN4s3v3cjtA5CFOyg9mncnc6mGi9-TMJfms28aupay4Zb4rg1Z0gxS8z5MmMPjsYBhsgztnQpiZKUU34f6C85loJJgv68i90F-cUyicKJYSWmjY31OuFcinmnKC_35sSc1O-KeWb2_IL--L3Q-_JX20X4HQBrvwAh3-bzMWH9aL8CfWbvSI</recordid><startdate>20170115</startdate><enddate>20170115</enddate><creator>Dai, Juncheng</creator><creator>Shen, Wei</creator><creator>Wen, Wanqing</creator><creator>Chang, Jiang</creator><creator>Wang, Tongmin</creator><creator>Chen, Haitao</creator><creator>Jin, Guangfu</creator><creator>Ma, Hongxia</creator><creator>Wu, Chen</creator><creator>Li, Lian</creator><creator>Song, Fengju</creator><creator>Zeng, YiXin</creator><creator>Jiang, Yue</creator><creator>Chen, Jiaping</creator><creator>Wang, Cheng</creator><creator>Zhu, Meng</creator><creator>Zhou, Wen</creator><creator>Du, Jiangbo</creator><creator>Xiang, Yongbing</creator><creator>Shu, Xiao‐Ou</creator><creator>Hu, Zhibin</creator><creator>Zhou, Weiping</creator><creator>Chen, Kexin</creator><creator>Xu, Jianfeng</creator><creator>Jia, Weihua</creator><creator>Lin, Dongxin</creator><creator>Zheng, Wei</creator><creator>Shen, Hongbing</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TO</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20170115</creationdate><title>Estimation of heritability for nine common cancers using data from genome‐wide association studies in Chinese population</title><author>Dai, Juncheng ; Shen, Wei ; Wen, Wanqing ; Chang, Jiang ; Wang, Tongmin ; Chen, Haitao ; Jin, Guangfu ; Ma, Hongxia ; Wu, Chen ; Li, Lian ; Song, Fengju ; Zeng, YiXin ; Jiang, Yue ; Chen, Jiaping ; Wang, Cheng ; Zhu, Meng ; Zhou, Wen ; Du, Jiangbo ; Xiang, Yongbing ; Shu, Xiao‐Ou ; Hu, Zhibin ; Zhou, Weiping ; Chen, Kexin ; Xu, Jianfeng ; Jia, Weihua ; Lin, Dongxin ; Zheng, Wei ; Shen, Hongbing</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4767-c9ae8ac2a48a62bcef3f96dc0c72b4f69b33a23cc098de53f7bbd430cc4c58393</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Asian Continental Ancestry Group - genetics</topic><topic>Cancer</topic><topic>Chinese population</topic><topic>Chromosomes - genetics</topic><topic>Female</topic><topic>Genetic Predisposition to Disease - genetics</topic><topic>Genome-Wide Association Study - methods</topic><topic>genome‐wide complex trait analysis</topic><topic>Genomics</topic><topic>Hepatitis B virus</topic><topic>heritability</topic><topic>Humans</topic><topic>Male</topic><topic>Medical research</topic><topic>Multifactorial Inheritance - genetics</topic><topic>Neoplasms - etiology</topic><topic>Neoplasms - genetics</topic><topic>Phenotype</topic><topic>Polymorphism, Single Nucleotide - genetics</topic><topic>Population genetics</topic><topic>single‐nucleotide polymorphisms</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dai, Juncheng</creatorcontrib><creatorcontrib>Shen, Wei</creatorcontrib><creatorcontrib>Wen, Wanqing</creatorcontrib><creatorcontrib>Chang, Jiang</creatorcontrib><creatorcontrib>Wang, Tongmin</creatorcontrib><creatorcontrib>Chen, Haitao</creatorcontrib><creatorcontrib>Jin, Guangfu</creatorcontrib><creatorcontrib>Ma, Hongxia</creatorcontrib><creatorcontrib>Wu, Chen</creatorcontrib><creatorcontrib>Li, Lian</creatorcontrib><creatorcontrib>Song, Fengju</creatorcontrib><creatorcontrib>Zeng, YiXin</creatorcontrib><creatorcontrib>Jiang, Yue</creatorcontrib><creatorcontrib>Chen, Jiaping</creatorcontrib><creatorcontrib>Wang, Cheng</creatorcontrib><creatorcontrib>Zhu, Meng</creatorcontrib><creatorcontrib>Zhou, Wen</creatorcontrib><creatorcontrib>Du, Jiangbo</creatorcontrib><creatorcontrib>Xiang, Yongbing</creatorcontrib><creatorcontrib>Shu, Xiao‐Ou</creatorcontrib><creatorcontrib>Hu, Zhibin</creatorcontrib><creatorcontrib>Zhou, Weiping</creatorcontrib><creatorcontrib>Chen, Kexin</creatorcontrib><creatorcontrib>Xu, Jianfeng</creatorcontrib><creatorcontrib>Jia, Weihua</creatorcontrib><creatorcontrib>Lin, Dongxin</creatorcontrib><creatorcontrib>Zheng, Wei</creatorcontrib><creatorcontrib>Shen, Hongbing</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International journal of cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dai, Juncheng</au><au>Shen, Wei</au><au>Wen, Wanqing</au><au>Chang, Jiang</au><au>Wang, Tongmin</au><au>Chen, Haitao</au><au>Jin, Guangfu</au><au>Ma, Hongxia</au><au>Wu, Chen</au><au>Li, Lian</au><au>Song, Fengju</au><au>Zeng, YiXin</au><au>Jiang, Yue</au><au>Chen, Jiaping</au><au>Wang, Cheng</au><au>Zhu, Meng</au><au>Zhou, Wen</au><au>Du, Jiangbo</au><au>Xiang, Yongbing</au><au>Shu, Xiao‐Ou</au><au>Hu, Zhibin</au><au>Zhou, Weiping</au><au>Chen, Kexin</au><au>Xu, Jianfeng</au><au>Jia, Weihua</au><au>Lin, Dongxin</au><au>Zheng, Wei</au><au>Shen, Hongbing</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Estimation of heritability for nine common cancers using data from genome‐wide association studies in Chinese population</atitle><jtitle>International journal of cancer</jtitle><addtitle>Int J Cancer</addtitle><date>2017-01-15</date><risdate>2017</risdate><volume>140</volume><issue>2</issue><spage>329</spage><epage>336</epage><pages>329-336</pages><issn>0020-7136</issn><eissn>1097-0215</eissn><abstract>The familial aggregation indicated the inheritance of cancer risk. Recent genome‐wide association studies (GWASs) have identified a number of common single‐nucleotide polymorphisms (SNPs). Following heritability analyses have shown that SNPs could explain a moderate amount of variance for different cancer phenotypes among Caucasians. However, little information was available in Chinese population. We performed a genome‐wide complex trait analysis for common cancers at nine anatomical sites in Chinese population (14,629 cancer cases vs. 17,554 controls) and estimated the heritability of these cancers based on the common SNPs. We found that common SNPs explained certain amount of heritability with significance for all nine cancer sites: gastric cancer (20.26%), esophageal squamous cell carcinoma (19.86%), colorectal cancer (16.30%), lung cancer (LC) (15.17%), and epithelial ovarian cancer (13.31%), and a similar heritability around 10% for hepatitis B virus‐related hepatocellular carcinoma, prostate cancer, breast cancer and nasopharyngeal carcinoma. We found that nearly or less than 25% change was shown when removing the regions expanding 250 kb or 500 kb upward and downward of the GWAS‐reported SNPs. We also found strong linear correlations between variance partitioned by each chromosome and chromosomal length only for LC (R2 = 0.641, p = 0.001) and esophageal squamous cell cancer (R2 = 0.633, p = 0.002), which implied us the complex heterogeneity of cancers. These results indicate polygenic genetic architecture of the nine common cancers in Chinese population. Further efforts should be made to discover the hidden heritability of different cancer types among Chinese. What's new? Almost every cancer exhibits familial aggregation. Here, the authors conducted a genome‐wide complex trait analysis in Chinese participants in previous genome‐wide association studies to estimate heritability explained by single‐nucleotide polymorphisms for nine common cancers (gastric, esophageal, colorectal, lung, ovarian, hepatocellular, prostrate, breast, and nasopharyngeal). The explained heritability ranged from 10.19% to 20.26% indicating a polygenic architecture of all examined cancer types. The authors recommend performing even larger studies to better analyze the hidden heritability of each cancer type.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>27668986</pmid><doi>10.1002/ijc.30447</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 0020-7136
ispartof International journal of cancer, 2017-01, Vol.140 (2), p.329-336
issn 0020-7136
1097-0215
language eng
recordid cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5536238
source MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Access via Wiley Online Library
subjects Asian Continental Ancestry Group - genetics
Cancer
Chinese population
Chromosomes - genetics
Female
Genetic Predisposition to Disease - genetics
Genome-Wide Association Study - methods
genome‐wide complex trait analysis
Genomics
Hepatitis B virus
heritability
Humans
Male
Medical research
Multifactorial Inheritance - genetics
Neoplasms - etiology
Neoplasms - genetics
Phenotype
Polymorphism, Single Nucleotide - genetics
Population genetics
single‐nucleotide polymorphisms
title Estimation of heritability for nine common cancers using data from genome‐wide association studies in Chinese population
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-17T10%3A57%3A29IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Estimation%20of%20heritability%20for%20nine%20common%20cancers%20using%20data%20from%20genome%E2%80%90wide%20association%20studies%20in%20Chinese%20population&rft.jtitle=International%20journal%20of%20cancer&rft.au=Dai,%20Juncheng&rft.date=2017-01-15&rft.volume=140&rft.issue=2&rft.spage=329&rft.epage=336&rft.pages=329-336&rft.issn=0020-7136&rft.eissn=1097-0215&rft_id=info:doi/10.1002/ijc.30447&rft_dat=%3Cproquest_pubme%3E1835397426%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1844969186&rft_id=info:pmid/27668986&rfr_iscdi=true